Osteotropic drug delivery system (ODDS) based on bisphosphonic prodrug. I.v. effects of osteotropic estradiol on bone mineral density and uterine weight in ovariectomized rats

• Published in: Journal of drug targeting Vol. 5; no. 2; p. 129
• Main Authors: Fujisaki, J, Tokunaga, Y, Takahashi, T, Shimojo, F, Kimura, S, Hata, T
• Format: Journal Article
• Language: English
• Published: England 1998
• Subjects: Animals; Bone Density - drug effects; Diphosphonates - administration & dosage; Disease Models, Animal; Estradiol - administration & dosage; Estradiol - pharmacology; Estrogen Replacement Therapy; Female; Injections, Intravenous; Organ Size - drug effects; Osteoporosis - prevention & control; Ovariectomy; Prodrugs - administration & dosage; Rats; Rats, Wistar; Uterus - drug effects

An osteotropic drug delivery system (ODDS) based on the bisphosphonic prodrug was designed for 17beta-estradiol (E2) in order to improve patient compliance in estrogen replacement therapy of postmenopausal osteoporosis. The bisphosphonic prodrug of E2, disodium [17beta-(3 '-hydroxy- 1',3&#...