Effect of adsorbents on the absorption of lansoprazole with surfactant

• Published in: International journal of pharmaceutics Vol. 289; no. 1; pp. 69 - 77
• Main Authors: Ito, Yukako, Arai, Harumi, Uchino, Kaori, Iwasaki, Kouji, Shibata, Nobuhito, Takada, Kanji
• Format: Journal Article
• Language: English
• Published: Amsterdam Elsevier B.V 31.01.2005; Elsevier
• Subjects: 2-Pyridinylmethylsulfinylbenzimidazoles; Absorption; Absorption - drug effects; Administration, Oral; Adosorbent; Adsorption; Animals; Area Under Curve; Bioavailability; Biological and medical sciences; Biological Availability; Dogs; Drug Evaluation, Preclinical - methods; Duodenum - drug effects; General pharmacology; Injections, Intravenous; Lansoprazole; Male; Medical sciences; Omeprazole - analogs & derivatives; Omeprazole - blood; Omeprazole - chemistry; Omeprazole - pharmacology; Oral administration; Pharmaceutical technology. Pharmaceutical industry; Pharmacology. Drug treatments; Powders - administration & dosage; Powders - chemistry; Powders - pharmacokinetics; Rats; Rats, Wistar; Silicon Dioxide - administration & dosage; Silicon Dioxide - pharmacokinetics; Solutions - administration & dosage; Solutions - chemistry; Solutions - pharmacokinetics; Surface-Active Agents - chemistry; Surface-Active Agents - metabolism; Surface-Active Agents - pharmacokinetics; Surfactant; Absorption; Bioavailability; Surfactant; Adosorbent; Lansoprazole; Oral administration; Pharmaceutical technology; Enzyme; H; Enzyme inhibitor; K; Proton pump inhibitor; Benzimidazole derivatives; Antisecretory agent; exchanging ATPase; Hydrolases; Pharmacokinetics

Lansoprazole (LPZ) is a representative drug that shows a high inter-subject variation of bioavailability (BA). Solid preparation composed of surfactant, adsorbent and LPZ were prepared to improve the dissolution and absorption of LPZ, and the BA of LPZ was measured in rats and dogs. As surfactant, T...