Increased galectin-1 expression in muscle of Astragalus polysaccharide-treated Type 1 diabetic mice

• Published in: Journal of natural medicines Vol. 65; no. 3-4; pp. 500 - 507
• Main Authors: Zhou, Xingjian, Xu, Yancheng, Yang, Guoming, Li, Fang
• Format: Journal Article
• Language: English
• Published: Japan Springer Japan 01.07.2011
• Subjects: Animals; Astragalus Plant - chemistry; Biomedical and Life Sciences; Biomedicine; Blotting, Western; Cells, Cultured; Complementary & Alternative Medicine; Diabetes Mellitus, Type 1 - chemically induced; Diabetes Mellitus, Type 1 - drug therapy; Diabetes Mellitus, Type 1 - immunology; Diabetes Mellitus, Type 1 - metabolism; Enzyme-Linked Immunosorbent Assay; Galectin 1 - genetics; Galectin 1 - metabolism; Male; Medicinal Chemistry; Mice; Mice, Inbred C57BL; Original Paper; Pharmacology/Toxicology; Pharmacy; Plant Sciences; Polysaccharides - chemistry; Polysaccharides - therapeutic use; Reverse Transcriptase Polymerase Chain Reaction; Galectin-1; Astragalus polysaccharide; Type 1 diabetes; CD8; T cell

In order to investigate the immunopharmacological function of Astragalus polysaccharide (APS) in Type 1 diabetes mellitus (T1DM), multiple low-dose streptozotocin-induced diabetic mice and normal mice were administered either APS or saline intraperitoneally once daily. The changes in galectin-1 expr...