Benzbromarone as adjuvant therapy for cystic fibrosis lung disease: a pilot clinical trial

• Published in: Jornal brasileiro de pneumologia Vol. 50; no. 3; p. e20230292
• Main Authors: Friedrich, Frederico, Petry, Lucas Montiel, Garcia, Laura de Castro E, Pieta, Marina Puerari, Meneses, Amanda da Silva, Bittencourt, Luana Braga, Xavier, Luiza Fernandes, Antunes, Marcos Otávio Brum, Grun, Lucas Kich, Lumertz, Magali, Kunzelmann, Karl, Pinto, Leonardo Araujo
• Format: Journal Article
• Language: English
• Published: Brazil Sociedade Brasileira de Pneumologia e Tisiologia 2024
• Subjects: Adolescent; Adult; Benzbromarone - administration & dosage; Benzbromarone - therapeutic use; Chemotherapy, Adjuvant; Cystic Fibrosis - drug therapy; Cystic Fibrosis - physiopathology; Cystic fibrosis/therapy; Female; Forced Expiratory Volume - drug effects; Humans; Male; Mucociliary clearance; Original; Pilot Projects; Prospective Studies; RESPIRATORY SYSTEM; respiratory tract diseases; Statistics, Nonparametric; Time Factors; Treatment Outcome; Uricosuric Agents - therapeutic use; Young Adult; Mucociliary clearance; Cystic fibrosis/therapy; respiratory tract diseases

Cystic fibrosis (CF) affects multiple organs, the most severe consequences being observed in the lungs. Despite significant progress in developing CF transmembrane conductance regulator-specific treatments for CF lung disease, exploring alternative CF-targeted medications seems reasonable. We sought...