SEM/EDX and confocal microscopy analysis of novel and conventional enteric-coated systems

• Published in: International journal of pharmaceutics Vol. 369; no. 1; pp. 72 - 78
• Main Authors: Liu, Fang, Lizio, Rosario, Schneider, Uwe J., Petereit, Hans-Ulrich, Blakey, Peter, Basit, Abdul W.
• Format: Journal Article
• Language: English
• Published: Amsterdam Elsevier B.V 18.03.2009; Elsevier
• Subjects: Adipic acid; Biological and medical sciences; Double coating; Enteric coatings; Enteric polymers; General pharmacology; Hydrogen-Ion Concentration; Hypromellose Derivatives; Intestine, Small - metabolism; Medical sciences; Methacrylates - chemistry; Methacrylic acid-ethyl acrylate copolymer; Methylcellulose - analogs & derivatives; Methylcellulose - chemistry; Microscopy, Confocal - methods; Microscopy, Electron, Scanning - methods; Modified release; Osmolar Concentration; pH-sensitive polymers; Pharmaceutical technology. Pharmaceutical industry; Pharmacology. Drug treatments; Polymer dissolution; Polymers - chemistry; Prednisolone - chemistry; Sodium - chemistry; Solubility; Spectrometry, X-Ray Emission - methods; Sub-coating; Tablets, Enteric-Coated; Methacrylic acid-ethyl acrylate copolymer; Polymer dissolution; Double coating; Modified release; Enteric polymers; pH-sensitive polymers; Enteric coatings; Sub-coating; Adipic acid; Scanning electron microscopy; Pharmaceutical technology; Controlled release form; Control release polymer; Confocal microscopy; Enteric coating; Dissolution; Acids; Dosage form; Ethyl acrylate copolymer

A novel double coating enteric system (comprising an inner layer of neutralised EUDRAGIT ® L 30 D-55 and organic acid, and an outer layer of standard EUDRAGIT ® L 30 D-55) was developed to provide fast dissolution in proximal small intestinal conditions. The mechanisms involved in the dissolution of...