Evaluating the effect of insulin sensitizers metformin and pioglitazone alone and in combination on women with polycystic ovary syndrome: An RCT

• Published in: International journal of reproductive biomedicine (Yazd, Iran) Vol. 14; no. 12; pp. 743 - 754
• Main Authors: Sohrevardi, Seyed Mojtaba, Nosouhi, Fahime, Hossein Khalilzade, Saeed, Kafaie, Parichehr, Karimi-Zarchi, Mojgan, Halvaei, Iman, Mohsenzadeh, Mehdi
• Format: Journal Article
• Language: English
• Published: Iran Research and Clinical Center for Infertility 01.12.2016
• Subjects: Original; Polycystic ovary syndrome; Insulin resistance; Metformin; Pioglitazone

Insulin resistance and hyperinsulinemia may play a role in pathogenesis of PCOS. One of the common therapeutic methods is using insulin-sensitizing drugs such as metformin and thiazolidinediones. The purpose was to determine the effect of metformin and pioglitazone on clinical, hormonal and metaboli...