Disassembly activity of actin-depolymerizing factor (ADF) is associated with distinct cellular processes in apicomplexan parasites

• Published in: Molecular biology of the cell Vol. 26; no. 17; pp. 3001 - 3012
• Main Authors: Haase, Silvia, Zimmermann, Dennis, Olshina, Maya A, Wilkinson, Mark, Fisher, Fabio, Tan, Yan Hong, Stewart, Rebecca J, Tonkin, Christopher J, Wong, Wilson, Kovar, David R, Baum, Jake
• Format: Journal Article
• Language: English
• Published: United States The American Society for Cell Biology 01.09.2015
• Subjects: Actin Cytoskeleton - metabolism; Actins - metabolism; Animals; Cell Movement - physiology; Cytoskeleton - metabolism; Destrin - genetics; Destrin - metabolism; Gene Knockout Techniques; Genetic Association Studies; Lysine - metabolism; Plasmodium falciparum - metabolism; Toxoplasma - metabolism

Proteins of the actin-depolymerizing factor (ADF)/cofilin family have been shown to be crucial for the motility and survival of apicomplexan parasites. However, the mechanisms by which ADF proteins fulfill their function remain poorly understood. In this study, we investigate the comparative activit...