The Human Papillomavirus (HPV) E6 Oncoprotein Regulates CD40 Expression via the AT-Hook Transcription Factor AKNA

• Published in: Cancers Vol. 10; no. 12; p. 521
• Main Authors: Manzo-Merino, Joaquin, Lagunas-Martínez, Alfredo, Contreras-Ochoa, Carla O, Lizano, Marcela, Castro-Muñoz, Leonardo J, Calderón-Corona, Crysele, Torres-Poveda, Kirvis, Román-Gonzalez, Alicia, Hernández-Pando, Rogelio, Bahena-Román, Margarita, Madrid-Marina, Vicente
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI 17.12.2018
• Subjects: proteasome; CD40; AKNA; E6 oncoprotein; HR-HPV; p53

Persistent infection with high-risk Human Papillomavirus (HR-HPV) is the main requisite for cervical cancer development. Normally, HPV is limited to the site of infection and regulates a plethora of cellular elements to avoid the immune surveillance by inducing an anti-inflammatory state, allowing t...