Usefulness of Clopidogrel Loading in Patients Who Underwent Transcatheter Aortic Valve Implantation (from the BRAVO-3 Randomized Trial)

• Published in: The American journal of cardiology Vol. 123; no. 9; pp. 1494 - 1500
• Main Authors: Nijenhuis, Vincent Johan, ten Berg, Jurrien Maria, Hengstenberg, Christian, Lefèvre, Thierry, Windecker, Stephan, Hildick-Smith, David, Kupatt, Christian, Van Belle, Eric, Tron, Christophe, Hink, Hans Ulrich, Colombo, Antonio, Claessen, Bimmer, Sartori, Samantha, Chandrasekhar, Jaya, Mehran, Roxana, Anthopoulos, Prodromos, Deliargyris, Efthymios N., Dangas, George
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.05.2019; Elsevier Limited
• Subjects: Aged, 80 and over; Anticoagulants; Aortic stenosis; Aortic valve; Aortic Valve Stenosis - surgery; Aspirin; Bleeding; Cardiovascular diseases; Cerebral infarction; Clinical outcomes; Clopidogrel; Clopidogrel - administration & dosage; Complications; Confidence intervals; Dose-Response Relationship, Drug; Drug dosages; Europe - epidemiology; Female; Follow-Up Studies; Health risks; Heart attacks; Heparin; Humans; Implantation; Incidence; Inhibitors; Ischemia; Kidneys; Male; Myocardial infarction; North America - epidemiology; Older people; Patients; Postoperative Complications - epidemiology; Postoperative Complications - etiology; Postoperative Complications - prevention & control; Preoperative Care - methods; Prospective Studies; Prostheses; Purinergic P2Y Receptor Antagonists - administration & dosage; Risk Assessment - methods; Risk Factors; Risk management; Sensitivity analysis; Sheaths; Stenosis; Stroke; Therapy; Thromboembolism; Thromboembolism - epidemiology; Thromboembolism - etiology; Thromboembolism - prevention & control; Time Factors; Transcatheter Aortic Valve Replacement - adverse effects; North America; Europe

P2Y12-inhibitor initiation with clopidogrel using a loading dose (LD) versus no LD (NLD) provides more rapid inhibition of platelet activation and reduced risk of ischemic events after coronary stenting. Whether a similar beneficial effect is achieved in the setting of transcatheter aortic valve imp...