A rapid strategy for screening high-efficiency PCSK9 inhibitors from Ginkgo biloba leaves by ligand fishing, HPLC-Q-TOF-MS and interdisciplinary assay

• Published in: Yàowu shi͡p︡in fenxi Vol. 28; no. 2; pp. 273 - 282
• Main Authors: Li, Li, Fan, Meng-Lin, Li, Ya-Nan, Huang, Ya-Xuan, Liu, Xiu-Feng, Liu, Ji-Hua
• Format: Journal Article
• Language: English
• Published: China (Republic : 1949- ) Taiwan Food and Drug Administration 15.06.2020
• Subjects: Original Research

Proprotein convertase subtilisin/kexin type 9 (PCSK9) is an attractive target for new cholesterol-lowering drug development. Here, we developed a method integrating ligand fishing, HPLC-Q-TOF-MS and interdisciplinary assay, aiming to explore potential PCSK9 inhibitors from mixtures rapidly and accur...