RRP6/EXOSC10 is required for the repair of DNA double-strand breaks by homologous recombination

• Published in: Journal of cell science Vol. 128; no. 6; pp. 1097 - 1107
• Main Authors: Marin-Vicente, Consuelo, Domingo-Prim, Judit, Eberle, Andrea B, Visa, Neus
• Format: Journal Article
• Language: English
• Published: England 15.03.2015
• Subjects: Animals; Blotting, Western; Cell Proliferation; Chromatin Immunoprecipitation; DNA Breaks, Double-Stranded; DNA repair; DNA Repair - genetics; Drosophila melanogaster; Drosophila melanogaster - genetics; Drosophila melanogaster - growth & development; Drosophila melanogaster - metabolism; Drosophila Proteins - genetics; Drosophila Proteins - metabolism; Exoribonucleases - antagonists & inhibitors; Exoribonucleases - genetics; Exoribonucleases - metabolism; EXOSC10; Exosome; Exosome Multienzyme Ribonuclease Complex - antagonists & inhibitors; Exosome Multienzyme Ribonuclease Complex - genetics; Exosome Multienzyme Ribonuclease Complex - metabolism; HeLa Cells; Histones - metabolism; Homologous Recombination - genetics; Humans; Molecular Bioscience; molekylär biovetenskap; Non-coding RNA; Phosphorylation; RAD51; Rad51 Recombinase - metabolism; RNA, Small Interfering - genetics; RRP6; RRP6; EXOSC10; RAD51; Exosome; DNA repair; Non-coding RNA

The exosome acts on different RNA substrates and plays important roles in RNA metabolism. The fact that short non-coding RNAs are involved in the DNA damage response led us to investigate whether the exosome factor RRP6 of Drosophila melanogaster and its human ortholog EXOSC10 play a role in DNA rep...