Overcoming functional challenges in autologous and engineered fat grafting trends

• Published in: Trends in biotechnology (Regular ed.) Vol. 40; no. 1; pp. 77 - 92
• Main Authors: Major, Gretel S., Simcock, Jeremy W., Woodfield, Tim B.F., Lim, Khoon S.
• Format: Journal Article
• Language: English
• Published: England Elsevier Ltd 01.01.2022; Elsevier Limited
• Subjects: Adipocytes; Adipose Tissue; Angiogenesis; Apoptosis; Autografts; autologous fat grafting; Bioengineering; Biomedical materials; Body fat; breast reconstruction; contour deformities; Grafting; Grafts; Ischemia; lipoaspirate; Reconstructive surgery; Retention; soft tissue regeneration; Soft tissues; Structural integrity; Transplantation, Autologous; Transplants & implants; Vascularization; lipoaspirate; adipose tissue; contour deformities; autologous fat grafting; soft tissue regeneration; breast reconstruction

Autologous fat grafting offers significant promise for the repair of soft tissue deformities; however, high resorption rates indicate that engineered solutions are required to improve adipose tissue (AT) survival. Advances in material development and biofabrication have laid the foundation for the g...