Two-ligand priming mechanism for potentiated phosphoinositide synthesis is an evolutionarily conserved feature of Sec14-like phosphatidylinositol and phosphatidylcholine exchange proteins

• Published in: Molecular biology of the cell Vol. 27; no. 14; pp. 2317 - 2330
• Main Authors: Huang, Jin, Ghosh, Ratna, Tripathi, Ashutosh, Lönnfors, Max, Somerharju, Pentti, Bankaitis, Vytas A.
• Format: Journal Article
• Language: English
• Published: United States The American Society for Cell Biology 15.07.2016
• Subjects: Amino Acid Sequence; Arabidopsis - metabolism; Arabidopsis Proteins - metabolism; Ligands; Membrane Proteins - metabolism; Phosphatidylcholines - metabolism; Phosphatidylinositol Phosphates - metabolism; Phosphatidylinositols - biosynthesis; Phosphatidylinositols - metabolism; Phospholipid Transfer Proteins - metabolism; Plant Proteins - metabolism; Plant Roots - metabolism; Protein Binding; Protein Domains; Signal Transduction

Lipid signaling, particularly phosphoinositide signaling, plays a key role in regulating the extreme polarized membrane growth that drives root hair development in plants. The Arabidopsis AtSFH1 gene encodes a two-domain protein with an amino-terminal Sec14-like phosphatidylinositol transfer protein...