Generating Novel and Soluble Class II Fructose-1,6-Bisphosphate Aldolase with ProteinGAN

• Published in: Catalysts Vol. 13; no. 12; p. 1457
• Main Authors: Tang, Fangfang, Ren, Mengyuan, Li, Xiaofan, Lin, Zhanglin, Yang, Xiaofeng
• Format: Journal Article
• Language: English
• Published: Basel MDPI AG 01.11.2023
• Subjects: Aldolase; Amino acids; Artificial intelligence; Bacteria; Binding sites; E coli; Enzymes; Escherichia coli; fructofructose-1,6-diphosphate aldolase; Fructose; Generative adversarial networks; Industrial applications; metabolic enzymes; Metabolism; Mutation; Natural resources; protein sequence design; ProteinGAN; Proteins

Fructose-1,6-bisphosphate aldolase (FBA) is an important enzyme involved in central carbon metabolism (CCM) with promising industrial applications. Artificial intelligence models like generative adversarial networks (GANs) can design novel sequences that differ from natural ones. To expand the seque...