Induction of DNA damage and apoptosis in Saccharomyces cerevisiae by a yeast killer toxin

• Published in: Cellular microbiology Vol. 7; no. 3; pp. 393 - 401
• Main Authors: Klassen, Roland, Meinhardt, Friedhelm
• Format: Journal Article
• Language: English
• Published: Oxford, UK Blackwell Science Ltd 01.03.2005
• Subjects: Apoptosis; Chitin Synthase - genetics; Chitin Synthase - metabolism; DNA Damage; DNA Fragmentation; In Situ Nick-End Labeling; Killer Factors, Yeast; Kluyveromyces lactis; Mutation; Mycotoxins - genetics; Mycotoxins - metabolism; Pichia - metabolism; Pichia acaciae; Reactive Oxygen Species - metabolism; S Phase; Saccharomyces cerevisiae; Saccharomyces cerevisiae - cytology; Saccharomyces cerevisiae - genetics; Saccharomyces cerevisiae - physiology; Saccharomyces cerevisiae Proteins - biosynthesis; Time Factors

Summary The cellular response of Saccharomyces cerevisiae to a linear plasmid encoded killer toxin from Pichia acaciae was analysed. As for the Kluyveromyces lactis zymocin, such toxin was recently shown to bind to the target cell's chitin and probably acts by facilitating the import of a toxin...