MicroRNA-766-3p Contributes to Anti-Inflammatory Responses through the Indirect Inhibition of NF-κB Signaling

• Published in: International journal of molecular sciences Vol. 20; no. 4; p. 809
• Main Authors: Hayakawa, Kunihiro, Kawasaki, Mikiko, Hirai, Takuya, Yoshida, Yuko, Tsushima, Hiroshi, Fujishiro, Maki, Ikeda, Keigo, Morimoto, Shinji, Takamori, Kenji, Sekigawa, Iwao
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 14.02.2019; MDPI
• Subjects: abatacept; Activator protein 1; Cytokines; Gene expression; IL-1β; Inflammation; interleukin(IL)-1β; microRNA (miRNA); MicroRNAs; mineralocorticoid receptor; miRNA; Monocyte chemoattractant protein 1; NF-κB protein; nuclear factor-κB (NF-κB); rheumatoid arthritis (RA); Signal transduction; Transcription factors; Tumor necrosis factor-TNF; Tumor necrosis factor-α; tumor necrosis factor-α (TNF-α); microRNA (miRNA); inflammation; interleukin(IL)-1β; abatacept; rheumatoid arthritis (RA); mineralocorticoid receptor; nuclear factor-κB (NF-κB); tumor necrosis factor-α (TNF-α)

MicroRNA (miRNA) is small RNA of 20 to 22 nucleotides in length and is stably present in plasma. Regulating the expression of miRNA taken into cells has been suggested as a general therapeutic approach. We identified the novel anti-inflammatory miRNA hsa-miR-766-3p and investigated its biological fu...