BTBR T+tf/J mice: Autism-relevant behaviors and reduced fractone-associated heparan sulfate

• Published in: Neuroscience and biobehavioral reviews Vol. 36; no. 1; pp. 285 - 296
• Main Authors: Blanchard, D. Caroline, Defensor, Erwin B., Meyza, Ksenia Z., Pobbe, Roger L.H., Pearson, Brandon L., Bolivar, Valerie J., Blanchard, Robert J.
• Format: Journal Article
• Language: English
• Published: Kidlington Elsevier 01.01.2012
• Subjects: Animals; Autistic Disorder - metabolism; Autistic Disorder - physiopathology; Behavioral psychophysiology; Biological and medical sciences; Child clinical studies; Developmental disorders; Disease Models, Animal; Exploratory Behavior; Fundamental and applied biological sciences. Psychology; Grooming; Heparitin Sulfate - metabolism; Humans; Infantile autism; Male; Medical sciences; Mice; Mice, Inbred Strains; Neuropharmacology; Pharmacology. Drug treatments; Psycholeptics: tranquillizer, neuroleptic; Psychology. Psychoanalysis. Psychiatry; Psychology. Psychophysiology; Psychopathology. Psychiatry; Psychopharmacology; Social Behavior; Gaze aversion; Gaze; BTBR T+tf/J; Psychotropic; Developmental disorder; Anticonvulsant; Review; Social behavior; Social proximity; Benzodiazepine derivatives; Heparitin sulfate; Diazepam; Heparan sulfate; Object preference; VBS; Rodentia; Hypnotic; Autism; Vertebrata; Mammalia; Tranquillizer; Mouse; Social interaction; Preference; Animal; Stereotypy

BTBR T+tf/J (BTBR) mice have emerged as strong candidates to serve as models of a range of autism-relevant behaviors, showing deficiencies in social behaviors; reduced or unusual ultrasonic vocalizations in conspecific situations; and enhanced, repetitive self-grooming. Recent studies have described...