Activation of invariant natural killer T cells impedes liver regeneration by way of both IFN‐γ‐ and IL‐4‐dependent mechanisms

• Published in: Hepatology (Baltimore, Md.) Vol. 60; no. 4; pp. 1356 - 1366
• Main Authors: Yin, Shi, Wang, Hua, Bertola, Adeline, Feng, Dechun, Xu, Ming‐jiang, Wang, Yan, Gao, Bin
• Format: Journal Article
• Language: English
• Published: United States 01.10.2014
• Subjects: Animals; Antigens, CD1d - genetics; Antigens, CD1d - physiology; Cell Proliferation - drug effects; Galactosylceramides - pharmacology; Hepatectomy; Hepatocytes - drug effects; Hepatocytes - pathology; In Vitro Techniques; Interferon-gamma - deficiency; Interferon-gamma - genetics; Interferon-gamma - physiology; Interleukin-4 - deficiency; Interleukin-4 - genetics; Interleukin-4 - physiology; Liver - drug effects; Liver - physiology; Liver - surgery; Liver Regeneration - drug effects; Liver Regeneration - physiology; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Models, Animal; Natural Killer T-Cells - pathology; Natural Killer T-Cells - physiology; STAT6 Transcription Factor - deficiency; STAT6 Transcription Factor - genetics; STAT6 Transcription Factor - physiology

Invariant natural killer T (iNKT) cells are a major subset of lymphocytes found in the liver. These cells mediate various functions, including hepatic injury, fibrogenesis, and carcinogenesis. However, the function of iNKT cells in liver regeneration remains unclear. In the present study, partial he...