Monocytes of patients with amyotrophic lateral sclerosis linked to gene mutations display altered TDP‐43 subcellular distribution

• Published in: Neuropathology and applied neurobiology Vol. 43; no. 2; pp. 133 - 153
• Main Authors: De Marco, G., Lomartire, A., Calvo, A., Risso, A., De Luca, E., Mostert, M., Mandrioli, J., Caponnetto, C., Borghero, G., Manera, U., Canosa, A., Moglia, C., Restagno, G., Fini, N., Tarella, C., Giordana, M. T., Rinaudo, M. T., Chiò, A.
• Format: Journal Article
• Language: English
• Published: England 01.02.2017
• Subjects: Adult; Aged; amyotrophic lateral sclerosis; Amyotrophic Lateral Sclerosis - genetics; Amyotrophic Lateral Sclerosis - metabolism; DNA-Binding Proteins - genetics; DNA-Binding Proteins - metabolism; Female; gene mutations; Humans; Male; Middle Aged; monocytes; Monocytes - metabolism; Mutation; transactive response DNA‐binding protein 43 subcellular localization; monocytes; gene mutations; amyotrophic lateral sclerosis; transactive response DNA-binding protein 43 subcellular localization

Aims Cytoplasmic accumulation of the nuclear protein transactive response DNA‐binding protein 43 (TDP‐43) is an early determinant of motor neuron degeneration in most amyotrophic lateral sclerosis (ALS) cases. We previously disclosed this accumulation in circulating lymphomonocytes (CLM) of ALS pati...