Adjuvant potential of selegiline in treating acute toxicity of aluminium phosphide in rats

• Published in: Basic & clinical pharmacology & toxicology Vol. 125; no. 1; pp. 62 - 74
• Main Authors: Maleki, Adeleh, Hosseini, Mir‐Jamal, Rahimi, Nastaran, Abdollahi, Alireza, Akbarfakhrabadi, Amir, Javadian, Nina, Amiri, Shayan, Behnoush, Behnam, Dehpour, Ahmad Reza
• Format: Journal Article
• Language: English
• Published: England Wiley Subscription Services, Inc 01.07.2019
• Subjects: Acute toxicity; aluminium phosphide; Aluminum; Aluminum Compounds - poisoning; Amine oxidase (flavin-containing); Animal tissues; Animals; Antidotes; Antidotes - administration & dosage; Antioxidants; Apoptosis; cardiac toxicity; Collapse; Disease Models, Animal; Drug Evaluation, Preclinical; Duodenum; Duodenum - drug effects; Duodenum - pathology; Echocardiography; EKG; Glutathione; Heart - drug effects; Heart rate; Humans; Injections, Intraperitoneal; Injuries; Intoxication; Male; Malondialdehyde; Medical treatment; Membrane potential; Membrane Potential, Mitochondrial - drug effects; Mitochondria; Mitochondria - drug effects; Mitochondria - pathology; Mood; Mortality; Movement disorders; Myocardium - pathology; Neurodegenerative diseases; Neurotoxicity; Oxidative stress; Oxidative Stress - drug effects; Parameters; Parkinson's disease; Pesticides - poisoning; Phosphides; Phosphine; Phosphines - poisoning; Poisoning; Poisoning - drug therapy; Poisoning - etiology; Poisoning - pathology; rat; Rats; Reactive oxygen species; Reactive Oxygen Species - metabolism; Selegiline; Selegiline - administration & dosage; Stomach; Stomach - drug effects; Stomach - pathology; Toxicity; Treatment Outcome; aluminium phosphide; cardiac toxicity; rat; mitochondria; selegiline

Aluminium phosphide (AlP) is a highly toxic substance with a high mortality rate and no effective antidote. Once exposed to the moisture and acidic conditions of the stomach, AlP releases toxic phosphine (PH3) gas, which results in severe toxicity in poisoned subjects. Selegiline is a monoamine oxid...