Effect of magnesium sulphate on sugammadex reversal time for neuromuscular blockade: a randomised controlled study
Summary Magnesium potentiates neuromuscular blockade. Sugammadex reverses rocuronium‐induced blockade. The aim of this study was to determine the effect of pre‐treatment with magnesium sulphate on sugammadex reversal time for neuromuscular blockade. Seventy‐three patients were randomly assigned to r...
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| Published in | Anaesthesia Vol. 70; no. 8; pp. 956 - 961 |
|---|---|
| Main Authors | , , , |
| Format | Journal Article |
| Language | English |
| Published |
England
Blackwell Publishing Ltd
01.08.2015
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| Subjects | |
| Online Access | Get full text |
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| Abstract | Summary
Magnesium potentiates neuromuscular blockade. Sugammadex reverses rocuronium‐induced blockade. The aim of this study was to determine the effect of pre‐treatment with magnesium sulphate on sugammadex reversal time for neuromuscular blockade. Seventy‐three patients were randomly assigned to receive magnesium sulphate (40 mg.kg−1) or saline intravenously. After anaesthetic induction, continuous train‐of‐four monitoring was performed and rocuronium was administered (0.6 mg.kg−1). When a second twitch appeared, the patients received sugammadex (2 mg.kg−1). The median (IQR [range]) reversal time of moderate neuromuscular blockade to a train‐of‐four ratio of 0.9 facilitated by sugammadex was 115 (93−177.5 [68−315]) s in the magnesium group and 120 (105−140 [70−298]) s in the saline group (p = 0.79). The median (IQR [range]) clinical duration was 45 (35.5−53 [22−102]) min in the magnesium group and 37 (31−43 [19−73]) min in the saline group (p = 0.031). Pre‐treatment with magnesium did not significantly affect sugammadex reversal time of moderate neuromuscular blockade induced by rocuronium. |
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| AbstractList | Magnesium potentiates neuromuscular blockade. Sugammadex reverses rocuronium-induced blockade. The aim of this study was to determine the effect of pre-treatment with magnesium sulphate on sugammadex reversal time for neuromuscular blockade. Seventy-three patients were randomly assigned to receive magnesium sulphate (40 mg.kg(-1) ) or saline intravenously. After anaesthetic induction, continuous train-of-four monitoring was performed and rocuronium was administered (0.6 mg.kg(-1) ). When a second twitch appeared, the patients received sugammadex (2 mg.kg(-1) ). The median (IQR [range]) reversal time of moderate neuromuscular blockade to a train-of-four ratio of 0.9 facilitated by sugammadex was 115 (93-177.5 [68-315]) s in the magnesium group and 120 (105-140 [70-298]) s in the saline group (p = 0.79). The median (IQR [range]) clinical duration was 45 (35.5-53 [22-102]) min in the magnesium group and 37 (31-43 [19-73]) min in the saline group (p = 0.031). Pre-treatment with magnesium did not significantly affect sugammadex reversal time of moderate neuromuscular blockade induced by rocuronium. Summary Magnesium potentiates neuromuscular blockade. Sugammadex reverses rocuronium‐induced blockade. The aim of this study was to determine the effect of pre‐treatment with magnesium sulphate on sugammadex reversal time for neuromuscular blockade. Seventy‐three patients were randomly assigned to receive magnesium sulphate (40 mg.kg −1 ) or saline intravenously. After anaesthetic induction, continuous train‐of‐four monitoring was performed and rocuronium was administered (0.6 mg.kg −1 ). When a second twitch appeared, the patients received sugammadex (2 mg.kg −1 ). The median (IQR [range]) reversal time of moderate neuromuscular blockade to a train‐of‐four ratio of 0.9 facilitated by sugammadex was 115 (93−177.5 [68−315]) s in the magnesium group and 120 (105−140 [70−298]) s in the saline group (p = 0.79). The median (IQR [range]) clinical duration was 45 (35.5−53 [22−102]) min in the magnesium group and 37 (31−43 [19−73]) min in the saline group (p = 0.031). Pre‐treatment with magnesium did not significantly affect sugammadex reversal time of moderate neuromuscular blockade induced by rocuronium. Summary Magnesium potentiates neuromuscular blockade. Sugammadex reverses rocuronium‐induced blockade. The aim of this study was to determine the effect of pre‐treatment with magnesium sulphate on sugammadex reversal time for neuromuscular blockade. Seventy‐three patients were randomly assigned to receive magnesium sulphate (40 mg.kg−1) or saline intravenously. After anaesthetic induction, continuous train‐of‐four monitoring was performed and rocuronium was administered (0.6 mg.kg−1). When a second twitch appeared, the patients received sugammadex (2 mg.kg−1). The median (IQR [range]) reversal time of moderate neuromuscular blockade to a train‐of‐four ratio of 0.9 facilitated by sugammadex was 115 (93−177.5 [68−315]) s in the magnesium group and 120 (105−140 [70−298]) s in the saline group (p = 0.79). The median (IQR [range]) clinical duration was 45 (35.5−53 [22−102]) min in the magnesium group and 37 (31−43 [19−73]) min in the saline group (p = 0.031). Pre‐treatment with magnesium did not significantly affect sugammadex reversal time of moderate neuromuscular blockade induced by rocuronium. Summary Magnesium potentiates neuromuscular blockade. Sugammadex reverses rocuronium-induced blockade. The aim of this study was to determine the effect of pre-treatment with magnesium sulphate on sugammadex reversal time for neuromuscular blockade. Seventy-three patients were randomly assigned to receive magnesium sulphate (40 mg.kg-1) or saline intravenously. After anaesthetic induction, continuous train-of-four monitoring was performed and rocuronium was administered (0.6 mg.kg-1). When a second twitch appeared, the patients received sugammadex (2 mg.kg-1). The median (IQR [range]) reversal time of moderate neuromuscular blockade to a train-of-four ratio of 0.9 facilitated by sugammadex was 115 (93-177.5 [68-315]) s in the magnesium group and 120 (105-140 [70-298]) s in the saline group (p = 0.79). The median (IQR [range]) clinical duration was 45 (35.5-53 [22-102]) min in the magnesium group and 37 (31-43 [19-73]) min in the saline group (p = 0.031). Pre-treatment with magnesium did not significantly affect sugammadex reversal time of moderate neuromuscular blockade induced by rocuronium. |
| Author | Germano Filho, P. A. Cavalcanti, I. L. Barrucand, L. Verçosa, N. |
| Author_xml | – sequence: 1 givenname: P. A. surname: Germano Filho fullname: Germano Filho, P. A. organization: Bonsucesso Federal Hospital (Hospital Federal de Bonsucesso)/Brazilian Ministry of Health – sequence: 2 givenname: I. L. surname: Cavalcanti fullname: Cavalcanti, I. L. organization: Fluminense Federal University (Universidade Federal Fluminense) – sequence: 3 givenname: L. surname: Barrucand fullname: Barrucand, L. organization: Federal University of Rio de Janeiro (Universidade Federal do Rio de Janeiro) – sequence: 4 givenname: N. surname: Verçosa fullname: Verçosa, N. organization: Bonsucesso Federal Hospital (Hospital Federal de Bonsucesso)/Brazilian Ministry of Health |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/25829048$$D View this record in MEDLINE/PubMed |
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| CitedBy_id | crossref_primary_10_1016_j_jclinane_2019_08_048 crossref_primary_10_1016_j_bjane_2021_07_023 crossref_primary_10_1097_01_sa_0000504621_69406_fa crossref_primary_10_1186_s40981_019_0248_8 crossref_primary_10_3389_fphar_2019_00429 crossref_primary_10_1111_anae_13320 crossref_primary_10_1016_j_jclinane_2023_111186 crossref_primary_10_1016_j_raa_2017_02_001 crossref_primary_10_28982_josam_954330 crossref_primary_10_1213_ANE_0000000000004505 crossref_primary_10_1016_j_jclinane_2016_06_011 crossref_primary_10_1016_j_bjane_2021_02_008 crossref_primary_10_1111_anae_13285 crossref_primary_10_17085_apm_19099 crossref_primary_10_1213_XAA_0000000000001058 crossref_primary_10_28982_josam_685701 crossref_primary_10_1097_EJA_0000000000001003 crossref_primary_10_1016_j_bpa_2016_12_002 crossref_primary_10_1186_s12871_017_0429_9 crossref_primary_10_1097_EJA_0000000000001329 crossref_primary_10_1097_EJA_0000000000000714 crossref_primary_10_1111_aas_12570 crossref_primary_10_1155_2022_8424670 crossref_primary_10_1097_ANA_0000000000000820 crossref_primary_10_1186_s12871_019_0734_6 crossref_primary_10_1097_ALN_0000000000004379 |
| Cites_doi | 10.1213/ANE.0b013e3181fdf889 10.1111/j.1399-6576.2007.01352.x 10.1097/EJA.0000000000000044 10.1111/j.1365-2044.2012.07102.x 10.1097/ALN.0b013e3182065c36 10.1097/MCP.0000000000000008 10.1093/bja/aes105 10.1093/bja/82.1.61 10.1016/j.annfar.2013.08.004 10.1213/ANE.0b013e3181da832d 10.1093/bja/aeg179 10.1093/bja/79.1.122 10.1093/bja/76.4.565 10.1186/1471-2393-13-239 10.1097/ALN.0b013e318210483d 10.4097/kjae.2013.65.1.4 10.1111/j.1399-6576.2009.02160.x 10.4097/kjae.2012.62.6.518 10.1007/s12630-013-9909-7 10.1097/ALN.0b013e31818a3fee 10.4097/kjae.2011.60.5.329 10.1093/bja/aei291 10.1097/ALN.0000000000000204 10.1007/s12630-011-9554-y 10.1097/EJA.0b013e32834e13a6 10.1097/EJA.0b013e328361d342 10.1093/bja/aer098 10.1684/mrh.2012.0315 10.1016/j.annfar.2013.03.008 10.1093/bja/aei314 |
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Magnesium potentiates neuromuscular blockade. Sugammadex reverses rocuronium‐induced blockade. The aim of this study was to determine the effect of... Magnesium potentiates neuromuscular blockade. Sugammadex reverses rocuronium-induced blockade. The aim of this study was to determine the effect of... Summary Magnesium potentiates neuromuscular blockade. Sugammadex reverses rocuronium-induced blockade. The aim of this study was to determine the effect of... |
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| SubjectTerms | Adult Androstanols - antagonists & inhibitors Anesthesia Clinical trials Double-Blind Method Female gamma-Cyclodextrins - pharmacology Humans Magnesium Sulfate - pharmacology Male Neuromuscular Blockade Neuromuscular Nondepolarizing Agents - antagonists & inhibitors Prospective Studies Sodium Chloride - administration & dosage Time Factors |
| Title | Effect of magnesium sulphate on sugammadex reversal time for neuromuscular blockade: a randomised controlled study |
| URI | https://onlinelibrary.wiley.com/doi/abs/10.1111%2Fanae.12987 https://www.ncbi.nlm.nih.gov/pubmed/25829048 https://www.proquest.com/docview/1694457688 https://search.proquest.com/docview/1695176699 |
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