Effect of magnesium sulphate on sugammadex reversal time for neuromuscular blockade: a randomised controlled study
Summary Magnesium potentiates neuromuscular blockade. Sugammadex reverses rocuronium‐induced blockade. The aim of this study was to determine the effect of pre‐treatment with magnesium sulphate on sugammadex reversal time for neuromuscular blockade. Seventy‐three patients were randomly assigned to r...
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Published in | Anaesthesia Vol. 70; no. 8; pp. 956 - 961 |
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Main Authors | , , , |
Format | Journal Article |
Language | English |
Published |
England
Blackwell Publishing Ltd
01.08.2015
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Abstract | Summary
Magnesium potentiates neuromuscular blockade. Sugammadex reverses rocuronium‐induced blockade. The aim of this study was to determine the effect of pre‐treatment with magnesium sulphate on sugammadex reversal time for neuromuscular blockade. Seventy‐three patients were randomly assigned to receive magnesium sulphate (40 mg.kg−1) or saline intravenously. After anaesthetic induction, continuous train‐of‐four monitoring was performed and rocuronium was administered (0.6 mg.kg−1). When a second twitch appeared, the patients received sugammadex (2 mg.kg−1). The median (IQR [range]) reversal time of moderate neuromuscular blockade to a train‐of‐four ratio of 0.9 facilitated by sugammadex was 115 (93−177.5 [68−315]) s in the magnesium group and 120 (105−140 [70−298]) s in the saline group (p = 0.79). The median (IQR [range]) clinical duration was 45 (35.5−53 [22−102]) min in the magnesium group and 37 (31−43 [19−73]) min in the saline group (p = 0.031). Pre‐treatment with magnesium did not significantly affect sugammadex reversal time of moderate neuromuscular blockade induced by rocuronium. |
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AbstractList | Magnesium potentiates neuromuscular blockade. Sugammadex reverses rocuronium-induced blockade. The aim of this study was to determine the effect of pre-treatment with magnesium sulphate on sugammadex reversal time for neuromuscular blockade. Seventy-three patients were randomly assigned to receive magnesium sulphate (40 mg.kg(-1) ) or saline intravenously. After anaesthetic induction, continuous train-of-four monitoring was performed and rocuronium was administered (0.6 mg.kg(-1) ). When a second twitch appeared, the patients received sugammadex (2 mg.kg(-1) ). The median (IQR [range]) reversal time of moderate neuromuscular blockade to a train-of-four ratio of 0.9 facilitated by sugammadex was 115 (93-177.5 [68-315]) s in the magnesium group and 120 (105-140 [70-298]) s in the saline group (p = 0.79). The median (IQR [range]) clinical duration was 45 (35.5-53 [22-102]) min in the magnesium group and 37 (31-43 [19-73]) min in the saline group (p = 0.031). Pre-treatment with magnesium did not significantly affect sugammadex reversal time of moderate neuromuscular blockade induced by rocuronium. Summary Magnesium potentiates neuromuscular blockade. Sugammadex reverses rocuronium‐induced blockade. The aim of this study was to determine the effect of pre‐treatment with magnesium sulphate on sugammadex reversal time for neuromuscular blockade. Seventy‐three patients were randomly assigned to receive magnesium sulphate (40 mg.kg −1 ) or saline intravenously. After anaesthetic induction, continuous train‐of‐four monitoring was performed and rocuronium was administered (0.6 mg.kg −1 ). When a second twitch appeared, the patients received sugammadex (2 mg.kg −1 ). The median (IQR [range]) reversal time of moderate neuromuscular blockade to a train‐of‐four ratio of 0.9 facilitated by sugammadex was 115 (93−177.5 [68−315]) s in the magnesium group and 120 (105−140 [70−298]) s in the saline group (p = 0.79). The median (IQR [range]) clinical duration was 45 (35.5−53 [22−102]) min in the magnesium group and 37 (31−43 [19−73]) min in the saline group (p = 0.031). Pre‐treatment with magnesium did not significantly affect sugammadex reversal time of moderate neuromuscular blockade induced by rocuronium. Summary Magnesium potentiates neuromuscular blockade. Sugammadex reverses rocuronium‐induced blockade. The aim of this study was to determine the effect of pre‐treatment with magnesium sulphate on sugammadex reversal time for neuromuscular blockade. Seventy‐three patients were randomly assigned to receive magnesium sulphate (40 mg.kg−1) or saline intravenously. After anaesthetic induction, continuous train‐of‐four monitoring was performed and rocuronium was administered (0.6 mg.kg−1). When a second twitch appeared, the patients received sugammadex (2 mg.kg−1). The median (IQR [range]) reversal time of moderate neuromuscular blockade to a train‐of‐four ratio of 0.9 facilitated by sugammadex was 115 (93−177.5 [68−315]) s in the magnesium group and 120 (105−140 [70−298]) s in the saline group (p = 0.79). The median (IQR [range]) clinical duration was 45 (35.5−53 [22−102]) min in the magnesium group and 37 (31−43 [19−73]) min in the saline group (p = 0.031). Pre‐treatment with magnesium did not significantly affect sugammadex reversal time of moderate neuromuscular blockade induced by rocuronium. Summary Magnesium potentiates neuromuscular blockade. Sugammadex reverses rocuronium-induced blockade. The aim of this study was to determine the effect of pre-treatment with magnesium sulphate on sugammadex reversal time for neuromuscular blockade. Seventy-three patients were randomly assigned to receive magnesium sulphate (40 mg.kg-1) or saline intravenously. After anaesthetic induction, continuous train-of-four monitoring was performed and rocuronium was administered (0.6 mg.kg-1). When a second twitch appeared, the patients received sugammadex (2 mg.kg-1). The median (IQR [range]) reversal time of moderate neuromuscular blockade to a train-of-four ratio of 0.9 facilitated by sugammadex was 115 (93-177.5 [68-315]) s in the magnesium group and 120 (105-140 [70-298]) s in the saline group (p = 0.79). The median (IQR [range]) clinical duration was 45 (35.5-53 [22-102]) min in the magnesium group and 37 (31-43 [19-73]) min in the saline group (p = 0.031). Pre-treatment with magnesium did not significantly affect sugammadex reversal time of moderate neuromuscular blockade induced by rocuronium. |
Author | Germano Filho, P. A. Cavalcanti, I. L. Barrucand, L. Verçosa, N. |
Author_xml | – sequence: 1 givenname: P. A. surname: Germano Filho fullname: Germano Filho, P. A. organization: Bonsucesso Federal Hospital (Hospital Federal de Bonsucesso)/Brazilian Ministry of Health – sequence: 2 givenname: I. L. surname: Cavalcanti fullname: Cavalcanti, I. L. organization: Fluminense Federal University (Universidade Federal Fluminense) – sequence: 3 givenname: L. surname: Barrucand fullname: Barrucand, L. organization: Federal University of Rio de Janeiro (Universidade Federal do Rio de Janeiro) – sequence: 4 givenname: N. surname: Verçosa fullname: Verçosa, N. organization: Bonsucesso Federal Hospital (Hospital Federal de Bonsucesso)/Brazilian Ministry of Health |
BackLink | https://www.ncbi.nlm.nih.gov/pubmed/25829048$$D View this record in MEDLINE/PubMed |
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CitedBy_id | crossref_primary_10_1016_j_jclinane_2019_08_048 crossref_primary_10_1016_j_bjane_2021_07_023 crossref_primary_10_1097_01_sa_0000504621_69406_fa crossref_primary_10_1186_s40981_019_0248_8 crossref_primary_10_3389_fphar_2019_00429 crossref_primary_10_1111_anae_13320 crossref_primary_10_1016_j_jclinane_2023_111186 crossref_primary_10_1016_j_raa_2017_02_001 crossref_primary_10_28982_josam_954330 crossref_primary_10_1213_ANE_0000000000004505 crossref_primary_10_1016_j_jclinane_2016_06_011 crossref_primary_10_1016_j_bjane_2021_02_008 crossref_primary_10_1111_anae_13285 crossref_primary_10_17085_apm_19099 crossref_primary_10_1213_XAA_0000000000001058 crossref_primary_10_28982_josam_685701 crossref_primary_10_1097_EJA_0000000000001003 crossref_primary_10_1016_j_bpa_2016_12_002 crossref_primary_10_1186_s12871_017_0429_9 crossref_primary_10_1097_EJA_0000000000001329 crossref_primary_10_1097_EJA_0000000000000714 crossref_primary_10_1111_aas_12570 crossref_primary_10_1155_2022_8424670 crossref_primary_10_1097_ANA_0000000000000820 crossref_primary_10_1186_s12871_019_0734_6 crossref_primary_10_1097_ALN_0000000000004379 |
Cites_doi | 10.1213/ANE.0b013e3181fdf889 10.1111/j.1399-6576.2007.01352.x 10.1097/EJA.0000000000000044 10.1111/j.1365-2044.2012.07102.x 10.1097/ALN.0b013e3182065c36 10.1097/MCP.0000000000000008 10.1093/bja/aes105 10.1093/bja/82.1.61 10.1016/j.annfar.2013.08.004 10.1213/ANE.0b013e3181da832d 10.1093/bja/aeg179 10.1093/bja/79.1.122 10.1093/bja/76.4.565 10.1186/1471-2393-13-239 10.1097/ALN.0b013e318210483d 10.4097/kjae.2013.65.1.4 10.1111/j.1399-6576.2009.02160.x 10.4097/kjae.2012.62.6.518 10.1007/s12630-013-9909-7 10.1097/ALN.0b013e31818a3fee 10.4097/kjae.2011.60.5.329 10.1093/bja/aei291 10.1097/ALN.0000000000000204 10.1007/s12630-011-9554-y 10.1097/EJA.0b013e32834e13a6 10.1097/EJA.0b013e328361d342 10.1093/bja/aer098 10.1684/mrh.2012.0315 10.1016/j.annfar.2013.03.008 10.1093/bja/aei314 |
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Copyright | 2015 The Association of Anaesthetists of Great Britain and Ireland 2015 The Association of Anaesthetists of Great Britain and Ireland. Copyright © 2015 The Association of Anaesthetists of Great Britain and Ireland |
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References_xml | – volume: 111 start-page: 120 year: 2010 end-page: 8 article-title: Residual neuromuscular block: lessons unlearned. Part I: definitions, incidence, and adverse physiologic effects of residual neuromuscular block publication-title: Anesthesia and Analgesia – volume: 106 start-page: 823 year: 2011 end-page: 6 article-title: Reversibility of rocuronium‐induced profound neuromuscular block with sugammadex in younger and older patients publication-title: British Journal of Anaesthesia – volume: 30 start-page: 599 year: 2013 end-page: 604 article-title: Effects of magnesium sulphate on the pharmacodynamics of rocuronium in patients aged 60 years and older: a randomised trial publication-title: European Journal of Anaesthesiology – volume: 13 start-page: 239 year: 2013 article-title: Working to improve survival and health for babies born very preterm: the WISH project protocol publication-title: BMC Pregnancy and Childbirth – volume: 114 start-page: 318 year: 2011 end-page: 29 article-title: Efficacy, safety, and pharmacokinetics of sugammadex for the reversal of rocuronium‐induced neuromuscular blockade in elderly patients publication-title: Anesthesiology – volume: 82 start-page: 61 year: 1999 end-page: 5 article-title: Antagonism of vecuronium‐induced neuromuscular block in patients pretreated with magnesium sulphate: dose‐effect relationship of neostigmine publication-title: British Journal of Anaesthesia – volume: 108 start-page: 730 year: 2012 end-page: 44 article-title: Perioperative management of hereditary arrhythmogenic syndromes publication-title: British Journal of Anaesthesia – volume: 58 start-page: 944 year: 2011 end-page: 7 article-title: Recurarization after sugammadex reversal in an obese patient publication-title: Canadian Journal of Anesthesia – volume: 32 start-page: 378 year: 2013 end-page: 9 article-title: Sugammadex and profound rocuronium neuromuscular blockade induced by magnesium sulphate publication-title: Annales Françaises d'Anésthesie et de Réanimation – volume: 65 start-page: 4 year: 2013 end-page: 8 article-title: Magnesium: a versatile drug for anesthesiologists publication-title: Korean Journal of Anesthesiology – volume: 60 start-page: 329 year: 2011 end-page: 33 article-title: Evaluation of dose effects of magnesium sulfate on rocuronium injection pain and hemodynamic changes by laryngoscopy and endotracheal intubation publication-title: Korean Journal of Anesthesiology – volume: 32 start-page: 838 year: 2013 end-page: 43 article-title: Impact of sugammadex on neuromuscular blocking agents use: a multicentric, pharmaco‐epidemiologic study in French university hospitals and military hospitals publication-title: Annales Françaises d'Anésthesie et de Réanimation – volume: 121 start-page: 59 year: 2014 end-page: 67 article-title: Efficacy of sugammadex for the reversal of moderate and deep rocuronium‐induced neuromuscular block in patients pretreated with intravenous magnesium: a randomized controlled trial publication-title: Anesthesiology – volume: 51 start-page: 789 year: 2007 end-page: 808 article-title: Good clinical research practice in pharmacodynamic studies of neuromuscular blocking agents II: the Stockholm revision publication-title: Acta Anaesthesiologica Scandinavica – volume: 62 start-page: 518 year: 2012 end-page: 23 article-title: Effect of magnesium sulfate pretreatment on onset and recovery characteristics of cisatracurium publication-title: Korean Journal of Anesthesiology – volume: 112 start-page: 63 year: 2011 end-page: 8 article-title: The duration of residual neuromuscular block after administration of neostigmine or sugammadex at two visible twitches during train‐of‐four monitoring publication-title: Anesthesia and Analgesia – volume: 109 start-page: 816 year: 2008 end-page: 24 article-title: Time from the start of administration of sugammadex to recovery of the TOF Ratio to 0.9 and T1 at the reappearance of T2 after the last dose of rocuronium publication-title: Anesthesiology – volume: 79 start-page: 122 year: 1997 end-page: 4 article-title: Administration of magnesium sulphate before rocuronium: effects on speed of onset and duration of neuromuscular block publication-title: British Journal of Anaesthesia – volume: 96 start-page: 247 year: 2006 end-page: 52 article-title: Effects of three different dose regimens of magnesium on propofol requirements, haemodynamic variables and postoperative pain relief in gynaecological surgery publication-title: British Journal of Anaesthesia – year: 1988 – volume: 91 start-page: 435 year: 2003 end-page: 8 article-title: Recurarization in the recovery room following the use of magnesium sulphate publication-title: British Journal of Anaesthesia – volume: 25 start-page: 72 year: 2012 end-page: 8 article-title: The effects of magnesium sulphate on desflurane requirement, early recovery and postoperative analgesia in laparascopic cholecystectomy publication-title: Magnesium Research – volume: 67 start-page: 748 year: 2012 end-page: 54 article-title: A randomised controlled trial comparing rocuronium priming, magnesium pre‐treatment and a combination of the two methods publication-title: Anaesthesia – volume: 60 start-page: 508 year: 2013 end-page: 9 article-title: Recurarization after sugammadex following a prolonged rocuronium infusion for induced hypothermia publication-title: Canadian Journal of Anesthesia – volume: 20 start-page: 103 year: 2014 end-page: 8 article-title: The role of magnesium sulfate in acute asthma: does route of administration make a difference? publication-title: Current Opinion in Pulmonary Medicine – volume: 96 start-page: 36 year: 2006 end-page: 43 article-title: Org 25969 (sugammadex), a selective relaxant binding agent for antagonism of prolonged rocuronium‐induced neuromuscular block publication-title: British Journal Anaesthesia – volume: 54 start-page: 299 year: 2010 end-page: 306 article-title: Time course of rocuronium‐induced neuromuscular block after pre‐treatment with magnesium sulphate: a randomised study publication-title: Acta Anaesthesiologica Scandinavica – volume: 29 start-page: 95 year: 2012 end-page: 9 article-title: Intravenous magnesium re‐establishes neuromuscular block after spontaneous recovery from an intubating dose of rocuronium: a randomised controlled trial publication-title: European Journal of Anaesthesiology – volume: 31 start-page: 183 year: 2014 end-page: 9 article-title: Preeclampsia: pathophysiology, old and new strategies for management publication-title: European Journal of Anaesthesiology – volume: 114 start-page: 971 year: 2011 end-page: 93 article-title: Magnesium – essentials for anesthesiologists publication-title: Anesthesiology – volume: 76 start-page: 565 year: 1996 end-page: 6 article-title: Magnesium sulphate enhances residual neuromuscular block induced by vecuronium publication-title: British Journal of Anaesthesia – ident: e_1_2_6_16_1 doi: 10.1213/ANE.0b013e3181fdf889 – ident: e_1_2_6_14_1 doi: 10.1111/j.1399-6576.2007.01352.x – ident: e_1_2_6_3_1 doi: 10.1097/EJA.0000000000000044 – ident: e_1_2_6_23_1 doi: 10.1111/j.1365-2044.2012.07102.x – volume-title: Statistical Power Analysis for the Behavioral Sciences year: 1988 ident: e_1_2_6_17_1 contributor: fullname: Cohen J – ident: e_1_2_6_29_1 doi: 10.1097/ALN.0b013e3182065c36 – ident: e_1_2_6_5_1 doi: 10.1097/MCP.0000000000000008 – ident: e_1_2_6_4_1 doi: 10.1093/bja/aes105 – ident: e_1_2_6_19_1 doi: 10.1093/bja/82.1.61 – ident: e_1_2_6_13_1 doi: 10.1016/j.annfar.2013.08.004 – ident: e_1_2_6_15_1 doi: 10.1213/ANE.0b013e3181da832d – ident: e_1_2_6_18_1 doi: 10.1093/bja/aeg179 – ident: e_1_2_6_24_1 doi: 10.1093/bja/79.1.122 – ident: e_1_2_6_22_1 doi: 10.1093/bja/76.4.565 – ident: e_1_2_6_7_1 doi: 10.1186/1471-2393-13-239 – ident: e_1_2_6_20_1 doi: 10.1097/ALN.0b013e318210483d – ident: e_1_2_6_2_1 doi: 10.4097/kjae.2013.65.1.4 – ident: e_1_2_6_9_1 doi: 10.1111/j.1399-6576.2009.02160.x – ident: e_1_2_6_11_1 doi: 10.4097/kjae.2012.62.6.518 – ident: e_1_2_6_31_1 doi: 10.1007/s12630-013-9909-7 – ident: e_1_2_6_28_1 doi: 10.1097/ALN.0b013e31818a3fee – ident: e_1_2_6_8_1 doi: 10.4097/kjae.2011.60.5.329 – ident: e_1_2_6_25_1 doi: 10.1093/bja/aei291 – ident: e_1_2_6_26_1 doi: 10.1097/ALN.0000000000000204 – ident: e_1_2_6_32_1 doi: 10.1007/s12630-011-9554-y – ident: e_1_2_6_21_1 doi: 10.1097/EJA.0b013e32834e13a6 – ident: e_1_2_6_12_1 doi: 10.1097/EJA.0b013e328361d342 – ident: e_1_2_6_30_1 doi: 10.1093/bja/aer098 – volume: 25 start-page: 72 year: 2012 ident: e_1_2_6_6_1 article-title: The effects of magnesium sulphate on desflurane requirement, early recovery and postoperative analgesia in laparascopic cholecystectomy publication-title: Magnesium Research doi: 10.1684/mrh.2012.0315 contributor: fullname: Olgun B – ident: e_1_2_6_10_1 doi: 10.1016/j.annfar.2013.03.008 – ident: e_1_2_6_27_1 doi: 10.1093/bja/aei314 |
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Magnesium potentiates neuromuscular blockade. Sugammadex reverses rocuronium‐induced blockade. The aim of this study was to determine the effect of... Magnesium potentiates neuromuscular blockade. Sugammadex reverses rocuronium-induced blockade. The aim of this study was to determine the effect of... Summary Magnesium potentiates neuromuscular blockade. Sugammadex reverses rocuronium-induced blockade. The aim of this study was to determine the effect of... |
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SubjectTerms | Adult Androstanols - antagonists & inhibitors Anesthesia Clinical trials Double-Blind Method Female gamma-Cyclodextrins - pharmacology Humans Magnesium Sulfate - pharmacology Male Neuromuscular Blockade Neuromuscular Nondepolarizing Agents - antagonists & inhibitors Prospective Studies Sodium Chloride - administration & dosage Time Factors |
Title | Effect of magnesium sulphate on sugammadex reversal time for neuromuscular blockade: a randomised controlled study |
URI | https://onlinelibrary.wiley.com/doi/abs/10.1111%2Fanae.12987 https://www.ncbi.nlm.nih.gov/pubmed/25829048 https://www.proquest.com/docview/1694457688 https://search.proquest.com/docview/1695176699 |
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