Gum mastic inhibits the expression and function of the androgen receptor in prostate cancer cells

• Published in: Cancer Vol. 106; no. 12; pp. 2547 - 2555
• Main Authors: He, Mei‐Lan, Yuan, Hui‐Qing, Jiang, An‐Li, Gong, Ai Yu, Chen, Wei‐Wen, Zhang, Peng‐Ju, Young, Charles Y. F., Zhang, Jian‐Ye
• Format: Journal Article
• Language: English
• Published: Hoboken Wiley Subscription Services, Inc., A Wiley Company 15.06.2006; Wiley-Liss
• Subjects: androgen receptor; Androgens - pharmacology; androgen‐regulated gene; Biological and medical sciences; Blotting, Western; Cell Line, Tumor; Cell Proliferation - drug effects; Cyclin D1 - genetics; Cyclin D1 - physiology; Disease Progression; Electrophoretic Mobility Shift Assay; Gene Expression Regulation, Neoplastic - drug effects; gum mastic; Homeodomain Proteins - genetics; Homeodomain Proteins - physiology; Humans; Male; Mastic Resin; Medical sciences; Neoplasms, Hormone-Dependent - chemistry; Neoplasms, Hormone-Dependent - genetics; Neoplasms, Hormone-Dependent - pathology; Neoplasms, Hormone-Dependent - physiopathology; Nephrology. Urinary tract diseases; Promoter Regions, Genetic - genetics; prostate cancer cell line; Prostate-Specific Antigen - analysis; Prostate-Specific Antigen - genetics; Prostatic Neoplasms - genetics; Prostatic Neoplasms - physiopathology; Prostatic Neoplasms - prevention & control; Protein Binding - drug effects; Receptors, Androgen - analysis; Receptors, Androgen - drug effects; Receptors, Androgen - genetics; Receptors, Androgen - physiology; Resins, Plant - pharmacology; Reverse Transcriptase Polymerase Chain Reaction; Tissue Kallikreins - genetics; Tissue Kallikreins - physiology; Transcription Factors - genetics; Transcription Factors - physiology; Transcription, Genetic - drug effects; Tumors; Tumors of the urinary system; Urinary tract. Prostate gland; Urinary system disease; Prostate disease; Androgen; Malignant tumor; Cancerology; Gene; androgen-regulated gene; Established cell line; Androgen receptor; gum mastic; Genetics; prostate cancer cell line; Inhibitor; Sex steroid hormone; Male genital diseases; Prostate cancer; Tumor cell; Gum; Hormonal receptor

Accumulating evidence suggests that the androgen receptor (AR) may play an important role in the development and progression of prostate cancer. To find new, useful compounds that effectively may attenuate the function of AR in prostate cancer cells, the authors investigated the effect of gum mastic...