Low versus high level of response to alcohol affects amygdala functional connectivity during processing of emotional stimuli

• Published in: Alcoholism, clinical and experimental research Vol. 46; no. 1; pp. 66 - 76
• Main Authors: McKenna, Benjamin S., Anthenelli, Robert M., Smith, Tom L., Schuckit, Marc A.
• Format: Journal Article
• Language: English
• Published: England 01.01.2022
• Subjects: Adolescent; alcohol; Alcoholic Intoxication - physiopathology; Alcoholic Intoxication - psychology; Amygdala - drug effects; Amygdala - physiopathology; Brain - drug effects; Brain - physiopathology; Cross-Over Studies; Double-Blind Method; emotional stimuli; Emotions - physiology; Ethanol - administration & dosage; Ethanol - pharmacology; Facial Expression; Female; functional connectivity; functional magnetic resonance imaging; Humans; level of response; Magnetic Resonance Imaging; Male; Neural Pathways - physiology; Young Adult; alcohol; level of response; functional connectivity; emotional stimuli; functional magnetic resonance imaging

Background Low levels of response (low LR) to alcohol predict heavy drinking and alcohol problems. Functional magnetic resonance imaging (fMRI) studies of emotion processing have shown that low LR individuals exhibit lower activation in task‐related brain regions following both placebo and alcohol a...