Nitrate and nitrite‐based therapy to attenuate cardiovascular remodelling in arterial hypertension

• Published in: Basic & clinical pharmacology & toxicology Vol. 128; no. 1; pp. 9 - 17
• Main Authors: Guimaraes, Danielle A., Batista, Rose I. M., Tanus‐Santos, Jose E.
• Format: Journal Article
• Language: English
• Published: England Wiley Subscription Services, Inc 01.01.2021
• Subjects: Angiotensin; Antihypertensives; Antioxidants; Bioavailability; Blood pressure; heart; Heart diseases; Hypertension; metalloproteinases; nitrate; Nitrates; Nitric oxide; nitrite; Nitrites; Oxidative stress; Renin; Signal transduction; vessels; metalloproteinases; nitrite; nitrate; heart; vessels

Hypertension is a highly prevalent disease marked by vascular and cardiac maladaptive remodelling induced mainly by renin‐angiotensin system activation followed by oxidative stress. Here, we briefly describe these damages and review the current evidence supporting a potential role for nitrate and ni...