Association of the vitamin D receptor gene start codon Fok I polymorphism with calcium oxalate stone disease

• Published in: BJU international Vol. 87; no. 3; pp. 168 - 171
• Main Authors: Chen, W.‐C., Chen, H.‐Y., Lu, H.‐F., Hsu, C.‐D., Tsai, F.‐J.
• Format: Journal Article
• Language: English
• Published: Oxford, UK Blackwell Science Ltd 01.02.2001; Blackwell
• Subjects: Adult; Aged; Biological and medical sciences; Calcium Oxalate; Codon - genetics; Female; Humans; Male; Medical sciences; Middle Aged; Nephrology. Urinary tract diseases; Polymerase Chain Reaction - methods; Polymorphism, Genetic; Receptors, Calcitriol - genetics; Risk Factors; single nucleotide polymorphisms; Urinary Calculi - genetics; Urinary lithiasis; urolithiasis; vitamin D receptor polymorphism; Human; Urinary system disease; Oxalate; Biological marker; Urinary tract disease; Urinary tract; Urinary stone; Polymerase chain reaction; Gene; Vitamin D; Calcium compound; Lithiasis; Genetics; Molecular biology; Polymorphism; Biological receptor

Objective To assess the use of Fok I polymorphism (the most frequent polymorphism, at the start codon of the vitamin D receptor gene, VDR) as a convenient genetic marker in identifying the cause of urolithiasis. Patients, subjects and methods A normal control group of 90 healthy subjects and 146 pat...