Association of AXIN1 rs12921862 C/A and rs1805105 G/A and CTSB rs12898 G/A polymorphisms with papillary thyroid carcinoma: A case–control study

• Published in: Journal of clinical laboratory analysis Vol. 37; no. 1; pp. e24804 - n/a
• Main Authors: Saljooghi, Shaghayegh, Heidari, Zahra, Saravani, Mohsen, Rezaei, Mahnaz, Salimi, Saeedeh
• Format: Journal Article
• Language: English
• Published: United States John Wiley & Sons, Inc 01.01.2023
• Subjects: Axin Protein - genetics; AXIN1; Biomarkers; Case-Control Studies; Cathepsin B; Cathepsin B - genetics; CTSB; Cysteine proteinase; Enzymes; Etiology; Gene polymorphism; Genes; Genetic factors; Genetic Predisposition to Disease - genetics; Genotype; Haplotypes; Humans; Kinases; Lymphatic system; Medical prognosis; Metastasis; Mutation; Papillary thyroid cancer; Papillary thyroid carcinoma; Polymorphism; Polymorphism, Single Nucleotide - genetics; Proteins; Radiation; Statistical analysis; Thyroid cancer; Thyroid Cancer, Papillary - genetics; Thyroid Neoplasms - genetics; tumor size; Tumor suppressor genes; Tumors; AXIN1; tumor size; polymorphism; papillary thyroid cancer; CTSB

Background Papillary thyroid cancer (PTC) is the most common type of thyroid cancer which its precise etiology remains unknown. However, environmental and genetic factors contribute to the etiology of PTC. Axis inhibition protein 1 (Axin1) is a scaffold protein that exerts its role as a tumor suppre...