How does the gut microbiome influence immune checkpoint blockade therapy?

• Published in: Immunology and cell biology Vol. 99; no. 4; p. 361
• Main Authors: Almonte, Andrew A, Rangarajan, Hareesha, Yip, Desmond, Fahrer, Aude M
• Format: Journal Article
• Language: English
• Published: United States 01.04.2021
• Subjects: gut microbiome; lymphocytes; tumor immunology; immunotherapy; CTLA-4/PD-1/PD-L1; T cells; immunology; immune checkpoint blockade

Immune checkpoint blockade (ICB) therapies are revolutionary cancer treatments; however, they only benefit about a third of patients. Therefore, extensive research is underway to find methods to improve their therapeutic efficacy. One avenue of study that has recently emerged is to consider the role...