Increased Level of Vascular Endothelial Growth Factors by 4-hexylresorcinol is Mediated by Transforming Growth Factor-β1 and Accelerates Capillary Regeneration in the Burns in Diabetic Animals
4-Hexyl resorcinol (4HR) is an organic compound and has been used in skin care application. 4HR is an M2-type macrophage activator and elevates vascular endothelial growth factor (VEGF) expression via the hypoxia-inducible factor (HIF)-independent pathway. As endothelial cells are important in wound...
Saved in:
| Published in | International journal of molecular sciences Vol. 21; no. 10; p. 3473 |
|---|---|
| Main Authors | , , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
Switzerland
MDPI AG
14.05.2020
MDPI |
| Subjects | |
| Online Access | Get full text |
Cover
Loading…
| Abstract | 4-Hexyl resorcinol (4HR) is an organic compound and has been used in skin care application. 4HR is an M2-type macrophage activator and elevates vascular endothelial growth factor (VEGF) expression via the hypoxia-inducible factor (HIF)-independent pathway. As endothelial cells are important in wound healing, the human umbilical vein endothelial cells (HUVECs) were treated with 4HR, and changes in VEGF-A, -C, and transforming growth factor-β1 (TGF-β1) expression were investigated. The administration of 4HR increased the expression level of VEGF-A, -C, and TGF-β1. The application of TGF-β1 protein also increased the expression level of VEGF-A and -C. Knockdown with small interfering RNA (siRNA) targeting to TGF-β1 and the selective chemical inhibition (A83-01) to ALK5 confirmed the involvement of the TGF-β signaling pathway in the 4-HR-mediated VEGFs expression. 4HR application in a burn model of diabetic rats demonstrated an increased level of angiogenic proteins with wound healing. Compared to sericin application, the 4HR application group showed more prominent capillary regeneration. Collectively, 4HR activated TGF-β1/ALK5/VEGFs signaling in endothelial cells and induced vascular regeneration and remodeling for wound healing. |
|---|---|
| AbstractList | 4-Hexyl resorcinol (4HR) is an organic compound and has been used in skin care application. 4HR is an M2-type macrophage activator and elevates vascular endothelial growth factor (VEGF) expression via the hypoxia-inducible factor (HIF)-independent pathway. As endothelial cells are important in wound healing, the human umbilical vein endothelial cells (HUVECs) were treated with 4HR, and changes in VEGF-A, -C, and transforming growth factor-β1 (TGF-β1) expression were investigated. The administration of 4HR increased the expression level of VEGF-A, -C, and TGF-β1. The application of TGF-β1 protein also increased the expression level of VEGF-A and -C. Knockdown with small interfering RNA (siRNA) targeting to TGF-β1 and the selective chemical inhibition (A83-01) to ALK5 confirmed the involvement of the TGF-β signaling pathway in the 4-HR-mediated VEGFs expression. 4HR application in a burn model of diabetic rats demonstrated an increased level of angiogenic proteins with wound healing. Compared to sericin application, the 4HR application group showed more prominent capillary regeneration. Collectively, 4HR activated TGF-β1/ALK5/VEGFs signaling in endothelial cells and induced vascular regeneration and remodeling for wound healing. |
| Author | Kang, Yei-Jin Oh, Ji-Hyeon Kim, Seong-Gon Kim, Dae-Won Garagiola, Umberto Choi, Je-Yong Jo, You-Young |
| AuthorAffiliation | 3 Biomedical, Surgical and Oral Sciences Department, Maxillofacial and Dental Unit, School of Dentistry, University of Milan, 20122 Milan, Italy; umberto.garagiola@unimi.it 1 Department of Oral Biochemistry, College of Dentistry, Gangneung-Wonju National University, Gangneung 28644, Korea; kimdw@gwnu.ac.kr 2 Sericultural and Apicultural Division, National Institute of Agricultural Science, Rural Development Administration, Wanju 55365, Korea; yyjo@korea.kr 5 Department of Oral and Maxillofacial Surgery, College of Dentistry, Gangneung-Wonju National University, Gangneung 28644, Korea; kyj292@hanmail.net (Y.-J.K.); haruna348@naver.com (J.-H.O.) 4 School of Biochemistry and Cell Biology, BK21 Plus KNU Biomedical Convergence Program, Skeletal Diseases Analysis Center, Korea Mouse Phenotyping Center (KMPC), Kyungpook National University, Daegu 41944, Korea; jechoi@knu.ac.kr |
| AuthorAffiliation_xml | – name: 5 Department of Oral and Maxillofacial Surgery, College of Dentistry, Gangneung-Wonju National University, Gangneung 28644, Korea; kyj292@hanmail.net (Y.-J.K.); haruna348@naver.com (J.-H.O.) – name: 4 School of Biochemistry and Cell Biology, BK21 Plus KNU Biomedical Convergence Program, Skeletal Diseases Analysis Center, Korea Mouse Phenotyping Center (KMPC), Kyungpook National University, Daegu 41944, Korea; jechoi@knu.ac.kr – name: 1 Department of Oral Biochemistry, College of Dentistry, Gangneung-Wonju National University, Gangneung 28644, Korea; kimdw@gwnu.ac.kr – name: 3 Biomedical, Surgical and Oral Sciences Department, Maxillofacial and Dental Unit, School of Dentistry, University of Milan, 20122 Milan, Italy; umberto.garagiola@unimi.it – name: 2 Sericultural and Apicultural Division, National Institute of Agricultural Science, Rural Development Administration, Wanju 55365, Korea; yyjo@korea.kr |
| Author_xml | – sequence: 1 givenname: Dae-Won surname: Kim fullname: Kim, Dae-Won organization: Department of Oral Biochemistry, College of Dentistry, Gangneung-Wonju National University, Gangneung 28644, Korea – sequence: 2 givenname: You-Young orcidid: 0000-0002-4424-2103 surname: Jo fullname: Jo, You-Young organization: Sericultural and Apicultural Division, National Institute of Agricultural Science, Rural Development Administration, Wanju 55365, Korea – sequence: 3 givenname: Umberto orcidid: 0000-0002-3256-6725 surname: Garagiola fullname: Garagiola, Umberto organization: Biomedical, Surgical and Oral Sciences Department, Maxillofacial and Dental Unit, School of Dentistry, University of Milan, 20122 Milan, Italy – sequence: 4 givenname: Je-Yong surname: Choi fullname: Choi, Je-Yong organization: School of Biochemistry and Cell Biology, BK21 Plus KNU Biomedical Convergence Program, Skeletal Diseases Analysis Center, Korea Mouse Phenotyping Center (KMPC), Kyungpook National University, Daegu 41944, Korea – sequence: 5 givenname: Yei-Jin surname: Kang fullname: Kang, Yei-Jin organization: Department of Oral and Maxillofacial Surgery, College of Dentistry, Gangneung-Wonju National University, Gangneung 28644, Korea – sequence: 6 givenname: Ji-Hyeon orcidid: 0000-0002-6050-7175 surname: Oh fullname: Oh, Ji-Hyeon organization: Department of Oral and Maxillofacial Surgery, College of Dentistry, Gangneung-Wonju National University, Gangneung 28644, Korea – sequence: 7 givenname: Seong-Gon orcidid: 0000-0001-5088-2732 surname: Kim fullname: Kim, Seong-Gon organization: Department of Oral and Maxillofacial Surgery, College of Dentistry, Gangneung-Wonju National University, Gangneung 28644, Korea |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/32423083$$D View this record in MEDLINE/PubMed |
| BookMark | eNpVks1uEzEQxy1URNvAjTOyxJUFrz_i9QUpDW2JFISECteVPxNHjh3sTSGvxRvwAjwTDilVcprx-D-_mbHnEpzFFC0AL1v0lhCB3vnVuuC2RYRy8gRctBTjBqExPzvyz8FlKSuEMMFMPAPnBFNMUEcuwO9Z1NnKYg2c23sbYHLwmyx6G2SG19GkYWmDlwHe5vRjWMIbqYeUC1Q7SJul_bkL2ZaUtY8pQF_gJ2u8HCqtCu6yjMWlvPZxcZrf_PnVQhkNnGhtg801o8Cp3PhQy-7gF7uwcR_1KUIfYe0BXm1zLPvDBy-VHbyGk-jXMpTn4Kmrxr54sCPw9eb6bvqxmX--nU0n80YTQUjDlO5YRxki2iCkOkoEZY44Z7lsx4wRJcZUMyOqy8ZGU8O4ZIi2hGMlO0dGYHbgmiRX_SbX4nnXJ-n7f4GUF73Mta9ge441otx0SjhGFWWCOsG5GDs37hQVqrLeH1ibrVpbo20csgwn0NOb6Jf9It1XMheoftwIvH4A5PR9a8vQr1J9oDp_jymitMMd5lX15qDSOZWSrXus0KJ-vzz98fJU-avjrh7F_7eF_AWGPMVW |
| CitedBy_id | crossref_primary_10_1186_s40902_022_00334_w crossref_primary_10_1186_s40902_022_00349_3 crossref_primary_10_3390_cimb45080426 crossref_primary_10_3390_app10238457 crossref_primary_10_3892_etm_2021_10456 crossref_primary_10_1016_j_heliyon_2023_e19452 crossref_primary_10_1186_s40902_022_00355_5 crossref_primary_10_3390_app11199128 crossref_primary_10_1097_MD_0000000000034940 crossref_primary_10_1051_bioconf_20213700089 crossref_primary_10_1371_journal_pone_0287147 crossref_primary_10_3389_fphar_2023_1288406 crossref_primary_10_1186_s40902_023_00378_6 crossref_primary_10_3390_app11083637 crossref_primary_10_3390_ijms25084316 crossref_primary_10_3390_app10165511 crossref_primary_10_3389_fphar_2021_631102 crossref_primary_10_3390_app11083486 crossref_primary_10_1016_j_ejps_2021_106031 crossref_primary_10_3892_or_2022_8375 crossref_primary_10_1007_s10787_023_01407_6 crossref_primary_10_1016_j_matdes_2023_112252 crossref_primary_10_1186_s40902_021_00326_2 |
| Cites_doi | 10.1080/10623320490482619 10.1016/j.burns.2016.04.016 10.1042/CS20040190 10.3390/ijms21041526 10.3390/ijms19030859 10.1021/tx800048m 10.3390/app10051737 10.1016/j.mattod.2015.11.004 10.1111/j.1349-7006.2005.00103.x 10.1016/j.jaad.2013.06.055 10.1016/j.burns.2016.06.005 10.1186/s40902-020-00267-2 10.1186/s40902-020-00249-4 10.1097/00005373-200008000-00022 10.1016/j.biomaterials.2014.10.017 10.1152/ajprenal.00052.2017 10.1002/jcp.26429 10.1007/s00403-013-1386-x 10.3390/ijms18071419 10.1186/s40902-019-0210-8 10.1111/srt.12619 10.1186/s40902-018-0173-1 10.1038/s41598-019-38946-4 10.3892/or.2012.1845 10.1016/j.febslet.2012.09.037 10.1186/1475-2840-7-8 10.1016/j.burns.2017.08.016 10.1016/S0140-6736(03)13169-8 10.1089/ten.tea.2009.0090 10.1016/j.exer.2017.08.008 10.1038/s41598-019-40027-5 |
| ContentType | Journal Article |
| Copyright | 2020. This work is licensed under http://creativecommons.org/licenses/by/3.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. 2020 by the authors. 2020 |
| Copyright_xml | – notice: 2020. This work is licensed under http://creativecommons.org/licenses/by/3.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. – notice: 2020 by the authors. 2020 |
| DBID | CGR CUY CVF ECM EIF NPM AAYXX CITATION 3V. 7X7 7XB 88E 8FI 8FJ 8FK 8G5 ABUWG AFKRA AZQEC BENPR CCPQU DWQXO FYUFA GHDGH GNUQQ GUQSH K9. M0S M1P M2O MBDVC PIMPY PQEST PQQKQ PQUKI PRINS Q9U 5PM DOA |
| DOI | 10.3390/ijms21103473 |
| DatabaseName | Medline MEDLINE MEDLINE (Ovid) MEDLINE MEDLINE PubMed CrossRef ProQuest Central (Corporate) Health & Medical Collection ProQuest Central (purchase pre-March 2016) Medical Database (Alumni Edition) Hospital Premium Collection Hospital Premium Collection (Alumni Edition) ProQuest Central (Alumni) (purchase pre-March 2016) Research Library (Alumni Edition) ProQuest Central (Alumni) ProQuest Central ProQuest Central Essentials ProQuest Databases ProQuest One Community College ProQuest Central Health Research Premium Collection Health Research Premium Collection (Alumni) ProQuest Central Student Research Library Prep ProQuest Health & Medical Complete (Alumni) Health & Medical Collection (Alumni Edition) Medical Database Research Library Research Library (Corporate) Publicly Available Content Database ProQuest One Academic Eastern Edition (DO NOT USE) ProQuest One Academic ProQuest One Academic UKI Edition ProQuest Central China ProQuest Central Basic PubMed Central (Full Participant titles) Directory of Open Access Journals |
| DatabaseTitle | MEDLINE Medline Complete MEDLINE with Full Text PubMed MEDLINE (Ovid) CrossRef Publicly Available Content Database Research Library Prep ProQuest Central Student ProQuest Central Essentials ProQuest Health & Medical Complete (Alumni) ProQuest Central (Alumni Edition) ProQuest One Community College Research Library (Alumni Edition) ProQuest Central China ProQuest Central Health Research Premium Collection Health and Medicine Complete (Alumni Edition) ProQuest Central Korea ProQuest Research Library ProQuest Medical Library (Alumni) ProQuest Central Basic ProQuest One Academic Eastern Edition ProQuest Hospital Collection Health Research Premium Collection (Alumni) ProQuest Hospital Collection (Alumni) ProQuest Health & Medical Complete ProQuest Medical Library ProQuest One Academic UKI Edition ProQuest One Academic ProQuest Central (Alumni) |
| DatabaseTitleList | MEDLINE CrossRef Publicly Available Content Database |
| Database_xml | – sequence: 1 dbid: DOA name: Directory of Open Access Journals url: https://www.doaj.org/ sourceTypes: Open Website – sequence: 2 dbid: NPM name: PubMed url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database – sequence: 3 dbid: EIF name: MEDLINE url: https://proxy.k.utb.cz/login?url=https://www.webofscience.com/wos/medline/basic-search sourceTypes: Index Database – sequence: 4 dbid: BENPR name: ProQuest Databases url: https://www.proquest.com/central sourceTypes: Aggregation Database |
| DeliveryMethod | fulltext_linktorsrc |
| Discipline | Biology |
| EISSN | 1422-0067 |
| ExternalDocumentID | oai_doaj_org_article_72c047d8b9f54b4594f97796ff68b49b 10_3390_ijms21103473 32423083 |
| Genre | Journal Article |
| GrantInformation_xml | – fundername: Rural Development Administration grantid: PJ01313902 |
| GroupedDBID | --- 29J 2WC 3V. 53G 5GY 5VS 7X7 88E 8FE 8FG 8FH 8FI 8FJ 8G5 A8Z AADQD AAFWJ AAHBH ABDBF ABJCF ABUWG ACGFO ACIHN ACIWK ACPRK ADBBV AEAQA AENEX AFKRA AFZYC ALIPV ALMA_UNASSIGNED_HOLDINGS AOIJS AZQEC BAWUL BBNVY BCNDV BENPR BHPHI BPHCQ BVXVI CCPQU CGR CS3 CUY CVF D1I DIK DU5 DWQXO E3Z EBD EBS ECM EIF EJD ESTFP ESX F5P FRP FYUFA GNUQQ GROUPED_DOAJ GUQSH GX1 HCIFZ HH5 HMCUK HYE IAO ITC KB. KQ8 LK8 M1P M2O M48 M7P MODMG M~E NPM O5R O5S OK1 P2P PDBOC PIMPY PQQKQ PROAC PSQYO RIG RNS RPM TR2 TUS UKHRP ~8M AAYXX AFPKN CITATION 7XB 8FK K9. MBDVC PQEST PQUKI PRINS Q9U 5PM |
| ID | FETCH-LOGICAL-c3933-5bc8584503cd00b843945f3ffe7a16553b964c5d955356dc4d57a5041372ba8f3 |
| IEDL.DBID | RPM |
| ISSN | 1422-0067 1661-6596 |
| IngestDate | Fri Oct 04 13:11:02 EDT 2024 Tue Sep 17 20:55:21 EDT 2024 Mon Oct 07 09:48:45 EDT 2024 Thu Sep 26 21:29:17 EDT 2024 Wed Oct 09 10:27:07 EDT 2024 |
| IsDoiOpenAccess | true |
| IsOpenAccess | true |
| IsPeerReviewed | true |
| IsScholarly | true |
| Issue | 10 |
| Keywords | HUVEC TGF-β1 diabetes mellitus 4-hexylresorcinol angiogenesis |
| Language | English |
| License | Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
| LinkModel | DirectLink |
| MergedId | FETCHMERGED-LOGICAL-c3933-5bc8584503cd00b843945f3ffe7a16553b964c5d955356dc4d57a5041372ba8f3 |
| ORCID | 0000-0002-6050-7175 0000-0002-3256-6725 0000-0002-4424-2103 0000-0001-5088-2732 |
| OpenAccessLink | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7279008/ |
| PMID | 32423083 |
| PQID | 2404482827 |
| PQPubID | 2032341 |
| ParticipantIDs | doaj_primary_oai_doaj_org_article_72c047d8b9f54b4594f97796ff68b49b pubmedcentral_primary_oai_pubmedcentral_nih_gov_7279008 proquest_journals_2404482827 crossref_primary_10_3390_ijms21103473 pubmed_primary_32423083 |
| PublicationCentury | 2000 |
| PublicationDate | 20200514 |
| PublicationDateYYYYMMDD | 2020-05-14 |
| PublicationDate_xml | – month: 5 year: 2020 text: 20200514 day: 14 |
| PublicationDecade | 2020 |
| PublicationPlace | Switzerland |
| PublicationPlace_xml | – name: Switzerland – name: Basel |
| PublicationTitle | International journal of molecular sciences |
| PublicationTitleAlternate | Int J Mol Sci |
| PublicationYear | 2020 |
| Publisher | MDPI AG MDPI |
| Publisher_xml | – name: MDPI AG – name: MDPI |
| References | Goutos (ref_6) 2015; 5 Kim (ref_18) 2019; 9 ref_33 Joob (ref_17) 2013; 305 ref_32 Amadasi (ref_31) 2009; 22 Duke (ref_7) 2016; 42 Kariya (ref_13) 2018; 314 ref_19 Tojo (ref_20) 2005; 96 Jeffcoate (ref_5) 2003; 361 Wang (ref_30) 1997; 11 Maresh (ref_16) 2008; 7 Mohammadian (ref_22) 2018; 233 Spiller (ref_12) 2015; 37 Kim (ref_8) 2020; 42 Chen (ref_9) 2016; 19 Ahn (ref_24) 2016; 42 Jo (ref_11) 2019; 9 Kim (ref_27) 2012; 28 ref_23 Rochon (ref_28) 2010; 16 (ref_25) 2019; 25 ref_3 Zou (ref_14) 2004; 11 Son (ref_1) 2019; 41 Jung (ref_2) 2018; 40 Kim (ref_10) 2017; 164 Ritchie (ref_15) 2004; 107 Feng (ref_21) 2012; 586 ref_4 Eyuboglu (ref_26) 2018; 44 Ozcan (ref_29) 2000; 49 |
| References_xml | – volume: 11 start-page: 89 year: 2004 ident: ref_14 article-title: Peroxynitrite and vascular endothelial dysfunction in diabetes mellitus publication-title: Endothelium doi: 10.1080/10623320490482619 contributor: fullname: Zou – volume: 5 start-page: 13 year: 2015 ident: ref_6 article-title: Diabetes mellitus and burns. Part II-outcomes from burn injuries and future directions publication-title: Int. J. Burn Trauma contributor: fullname: Goutos – volume: 42 start-page: 1534 year: 2016 ident: ref_24 article-title: Topical delivery of 4-hexylresorcinol promotes wound healing via tumor necrosis factor-α suppression publication-title: Burns doi: 10.1016/j.burns.2016.04.016 contributor: fullname: Ahn – volume: 107 start-page: 519 year: 2004 ident: ref_15 article-title: The role of insulin and the adipocytokines in regulation of vascular endothelial function publication-title: Clin. Sci. doi: 10.1042/CS20040190 contributor: fullname: Ritchie – ident: ref_19 doi: 10.3390/ijms21041526 – ident: ref_32 doi: 10.3390/ijms19030859 – volume: 22 start-page: 52 year: 2009 ident: ref_31 article-title: Identification of xenoestrogens in food additives by an integrated in silico and in vitro approach publication-title: Chem. Res. Toxicol. doi: 10.1021/tx800048m contributor: fullname: Amadasi – ident: ref_33 doi: 10.3390/app10051737 – volume: 19 start-page: 304 year: 2016 ident: ref_9 article-title: Osteoimmunomodulation for the development of advanced bone biomaterials publication-title: Mater. Today doi: 10.1016/j.mattod.2015.11.004 contributor: fullname: Chen – volume: 96 start-page: 791 year: 2005 ident: ref_20 article-title: The ALK-5 inhibitor A-83-01 inhibits Smad signaling and epithelial-to-mesenchymal transition by transforming growth factor-beta publication-title: Cancer Sci. doi: 10.1111/j.1349-7006.2005.00103.x contributor: fullname: Tojo – ident: ref_4 doi: 10.1016/j.jaad.2013.06.055 – volume: 42 start-page: 1734 year: 2016 ident: ref_7 article-title: Increased admissions for diabetes mellitus after burn publication-title: Burns doi: 10.1016/j.burns.2016.06.005 contributor: fullname: Duke – ident: ref_23 doi: 10.1186/s40902-020-00267-2 – volume: 42 start-page: 5 year: 2020 ident: ref_8 article-title: Immunomodulation for maxillofacial reconstructive surgery publication-title: Maxillofac. Plast. Reconstr. Surg. doi: 10.1186/s40902-020-00249-4 contributor: fullname: Kim – volume: 49 start-page: 327 year: 2000 ident: ref_29 article-title: Effect of nitric oxide synthase inhibitor on experimentally induced burn wounds publication-title: J. Trauma doi: 10.1097/00005373-200008000-00022 contributor: fullname: Ozcan – volume: 37 start-page: 194 year: 2015 ident: ref_12 article-title: Sequential delivery of immunomodulatory cytokines to facilitate the M1-to-M2 transition of macrophages and enhance vascularization of bone scaffolds publication-title: Biomaterials doi: 10.1016/j.biomaterials.2014.10.017 contributor: fullname: Spiller – volume: 314 start-page: F167 year: 2018 ident: ref_13 article-title: TGF-β1-VEGF-A pathway induces neoangiogenesis with peritoneal fibrosis in patients undergoing peritoneal dialysis publication-title: Am. J. Physiol. Renal Physiol. doi: 10.1152/ajprenal.00052.2017 contributor: fullname: Kariya – volume: 233 start-page: 6425 year: 2018 ident: ref_22 article-title: Macrophage plasticity, polarization, and function in health and disease publication-title: J. Cell Physiol. doi: 10.1002/jcp.26429 contributor: fullname: Mohammadian – volume: 305 start-page: 555 year: 2013 ident: ref_17 article-title: Silk sericin and burn wound publication-title: Arch. Dermatol. Res. doi: 10.1007/s00403-013-1386-x contributor: fullname: Joob – ident: ref_3 doi: 10.3390/ijms18071419 – volume: 41 start-page: 26 year: 2019 ident: ref_1 article-title: Pharmacoepidemiology and clinical characteristics of medication-related osteonecrosis of the jaw publication-title: Maxillofac. Plast. Reconstr. Surg. doi: 10.1186/s40902-019-0210-8 contributor: fullname: Son – volume: 25 start-page: 118 year: 2019 ident: ref_25 article-title: Detecting and quantifying activity/inflammation in localized scleroderma with thermal imaging publication-title: Skin Res. Technol. doi: 10.1111/srt.12619 – volume: 40 start-page: 34 year: 2018 ident: ref_2 article-title: Development of an experimental model for radiation-induced inhibition of cranial bone regeneration publication-title: Maxillofac. Plast. Reconstr. Surg. doi: 10.1186/s40902-018-0173-1 contributor: fullname: Jung – volume: 9 start-page: 3379 year: 2019 ident: ref_18 article-title: Effects of 4-hexylresorcinol on protein expressions in RAW 264.7 cells as determined by immunoprecipitation high performance liquid chromatography publication-title: Sci. Rep. doi: 10.1038/s41598-019-38946-4 contributor: fullname: Kim – volume: 28 start-page: 677 year: 2012 ident: ref_27 article-title: 4-hexylresorcinol stimulates the differentiation of SCC-9 cells through the suppression of E2F2, E2F3 and Sp3 expression and the promotion of Sp1 expression publication-title: Oncol. Rep. doi: 10.3892/or.2012.1845 contributor: fullname: Kim – volume: 586 start-page: 3951 year: 2012 ident: ref_21 article-title: Inhibition of amyloid fibrillation of lysozyme by phenolic compounds involves quinoprotein formation publication-title: FEBS Lett. doi: 10.1016/j.febslet.2012.09.037 contributor: fullname: Feng – volume: 11 start-page: 257 year: 1997 ident: ref_30 article-title: TGF-beta 1 gene expression in the healing process of skin wound in rat publication-title: Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi contributor: fullname: Wang – volume: 7 start-page: 8 year: 2008 ident: ref_16 article-title: In vivo endothelial gene regulation in diabetes publication-title: Cardiovasc. Diabetol. doi: 10.1186/1475-2840-7-8 contributor: fullname: Maresh – volume: 44 start-page: 386 year: 2018 ident: ref_26 article-title: The effect of adipose derived stromal vascular fraction on stasis zone in an experimental burn model publication-title: Burns doi: 10.1016/j.burns.2017.08.016 contributor: fullname: Eyuboglu – volume: 361 start-page: 1545 year: 2003 ident: ref_5 article-title: Diabetic foot ulcers publication-title: Lancet doi: 10.1016/S0140-6736(03)13169-8 contributor: fullname: Jeffcoate – volume: 16 start-page: 1457 year: 2010 ident: ref_28 article-title: Normal human epithelial cells regulate the size and morphology of tissue-engineered capillaries publication-title: Tissue Eng. Part A doi: 10.1089/ten.tea.2009.0090 contributor: fullname: Rochon – volume: 164 start-page: 74 year: 2017 ident: ref_10 article-title: TNF-α upregulates HIF-1α expression in pterygium fibroblasts and enhances their susceptibility to VEGF independent of hypoxia publication-title: Exp. Eye Res. doi: 10.1016/j.exer.2017.08.008 contributor: fullname: Kim – volume: 9 start-page: 3448 year: 2019 ident: ref_11 article-title: 4-Hexylresorcinol and silk sericin increase the expression of vascular endothelial growth factor via different pathways publication-title: Sci. Rep. doi: 10.1038/s41598-019-40027-5 contributor: fullname: Jo |
| SSID | ssj0023259 |
| Score | 2.4444492 |
| Snippet | 4-Hexyl resorcinol (4HR) is an organic compound and has been used in skin care application. 4HR is an M2-type macrophage activator and elevates vascular... |
| SourceID | doaj pubmedcentral proquest crossref pubmed |
| SourceType | Open Website Open Access Repository Aggregation Database Index Database |
| StartPage | 3473 |
| SubjectTerms | 4-hexylresorcinol Angiogenesis Animals Apoptosis Burns Burns - complications Burns - drug therapy Burns - genetics Burns - pathology Cytokines Diabetes Diabetes mellitus Diabetes Mellitus, Experimental - complications Diabetes Mellitus, Experimental - drug therapy Diabetes Mellitus, Experimental - genetics Disease Models, Animal Endothelial cells Growth factors Human Umbilical Vein Endothelial Cells Humans HUVEC Hypotheses Hypoxia-inducible factors Macrophages Macrophages - metabolism Organic compounds Permeability Proteins Rats Receptor, Transforming Growth Factor-beta Type I - genetics Resorcinol Resorcinols - pharmacology RNA, Small Interfering - genetics RNA, Small Interfering - pharmacology Signal transduction Signal Transduction - drug effects siRNA TGF-β1 Transforming Growth Factor beta1 - genetics Transforming growth factor-b1 Tumor necrosis factor-TNF Ulcers Umbilical vein Vascular endothelial growth factor Vascular Endothelial Growth Factor A - genetics Vascular Endothelial Growth Factor C - genetics Wound healing Wound Healing - drug effects |
| SummonAdditionalLinks | – databaseName: Directory of Open Access Journals dbid: DOA link: http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwrV1Lb9QwELZQJSQuiDeBguYAx6hJ_IqP26pLhSgH1KLeovjFBm2z1WaR2L_FP-AP8JsY29lqg5C4cMvDTpzMjOf7rPEMIW8UY6YMK_ey1jYu3eQ1ZSZvrbcFTn8mVW84_yjOLtn7K361V-orxISl9MDpxx3JyhRM2lorz5lmXDGPkEUJ70WtmdJx9i35jkyNVItWsUxaid4nF1yJFPJOkeAfdV-vh8B6KJN04oxizv6_Ac0_4yX3HND8Abk_IkeYpRE_JHdc_4jcTbUkt4_JT7T0EGDuLHwIgUCw8vB5DDOF096GnVZLVDZ4h8R7s4B5KrQDegssX7jv2yUS79XadP1qCd0A57GGBz4NG1zs0C36uWn__NePEtrewswYdGAh78QAJ-1NqGW03sIn9yWmtQ7Sh64HHAMc43cM4SQF43QGZn13jVbwhFzOTy9OzvKxPkNuqKI059rUiF94QY0tCl2HTbbcU--dbEvBOdVKMMOtwkMurGGWy5YX6DZlpdva06fkoF_17jkBJirthWod9mbOuJYrY5A8MVcbXyuRkbc7QTU3KQ1Hg_QlCLTZF2hGjoMUb9uE5NnxAqpUM6pU8y-VysjhTgea0aKHBpEPMlkkqDIjz5I63L4lglLEshmRE0WZDGN6p-8WMZc3wkeFMOzF_xj3S3KvCqsBIbcsOyQHm_U39woh00a_jtbxG_miFqk priority: 102 providerName: Directory of Open Access Journals – databaseName: Health & Medical Collection dbid: 7X7 link: http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwfV3LbtNAFB2VIiQ2iDcuBc0CllZsz8uzQmnVECHKArUoO8vzalyldoiD1PwWf8AP8E3cGdttjRC7POzY0T0z95zxnXsQeicp1alfuRe5MmHpJs4J1XFpnElg-tOde8PpFz4_p58WbLGH5sNeGF9WOcyJYaI2jfZr5BPIPKAkQCCISan8KoDeTj6sv8feP8o_Z-3NNO6h-2kGtAKQLRa30otkwTYthWwUcyZ5VwJPQPBPqsur1qsgQgUZJafQw_9fxPPv-sk7CWn2GD3qmSSedqF_gvZs_RQ96Lwld8_QLxj5vuDcGvzZFwbhxuFvfdkpPqmN33m1AvDhjyDEt0s864x3sNphGi_t9W4FQrzZ6KpuVrhq8Wnw9IBfgwPOBrYLeW98fvz7Z4rL2uCp1pDQfB-KFh-Xa-9ttNnhr_YitLn2aMBVjeEe8BH8j9a_6YpzKo2ndXUFo-I5Op-dnB3P496vIdZEEhIzpXPgMywh2iSJyv2mW-aIc1aUKWeMKMmpZkbCS8aNpoaJkiWQRkWmytyRF2i_bmr7CmHKM-W4LC2cTa22JZNag5iiNtculzxC74dAFeuuLUcBcsYHtLgb0Agd-SjeHOObaYcPms1F0Y_NQmQ6ocLkSjpGFWWSOmDFkjvHc0WlitDhgIGiH-FtcYvHCL3s4HBzlUBSAYQREiOgjG5j_E1dLUNvb6CTEmjZwf8v-Ro9zLzu911k6SHa325-2DdAjrbqbcD9H45hEjM priority: 102 providerName: ProQuest – databaseName: Scholars Portal Open Access Journals dbid: M48 link: http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwrV3JbtRAEG2FICQuiB1DQHWAo8Ezvdh9iNAkyhAhhgPKoNws95ZxNLGDPZHi3-IP-AG-iWovoxhy5Oat7bar2vVeu1yPkLeSMT3xM_dxokw7dRMmlOkwM85E-PrTnXrD4qs4XrLPp_x0hwxqo_0DrG-ldl5Palmt31__aD7igN_3jBMp-4f8_KL2PIaymN4hd6eMMu_rC7b9noCwoZVNm2A0CgWXokuB_6f1KDi1NfxvA55_50_eCEjzh-RBjyRh1pn-EdmxxWNyr9OWbJ6QXzjyfcK5NfDFJwZB6eB7n3YKR4Xxf16t0fngExLxzQrmnfAOqAZYuLLXzRqJeFnpvCjXkNewaDU98Gx4wMmAdjHujduHv39OICsMzLTGgObrUNRwmF16baOqgW_2rC1z7b0B8gKwD3CA91H7lS45J9cwK_ILtM5TspwfnRweh71eQ6ippDTkSieIZ3hEtYkilfifbrmjztk4mwjOqZKCaW4kLnJhNDM8zniEYTSeqixx9BnZLcrCviDAxFQ5ITOLrZnVNuNSayRTzCbaJVIE5N1gqPSyK8uRIp3xBk1vGjQgB96K22N8Me12Q1mdpf3YTOOpjlhsEiUdZ4pxyRyiYimcE4liUgVkb_CBdHDQFJEQMlskrHFAnnfusL1KC1IR2wYkHjnKqBvjPUW-amt7I5yUCMte_o9-vyL3p352wNeaZXtkd1Nd2dcIoTbqTTs6_gAmSh4A priority: 102 providerName: Scholars Portal |
| Title | Increased Level of Vascular Endothelial Growth Factors by 4-hexylresorcinol is Mediated by Transforming Growth Factor-β1 and Accelerates Capillary Regeneration in the Burns in Diabetic Animals |
| URI | https://www.ncbi.nlm.nih.gov/pubmed/32423083 https://www.proquest.com/docview/2404482827/abstract/ https://pubmed.ncbi.nlm.nih.gov/PMC7279008 https://doaj.org/article/72c047d8b9f54b4594f97796ff68b49b |
| Volume | 21 |
| hasFullText | 1 |
| inHoldings | 1 |
| isFullTextHit | |
| isPrint | |
| link | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV1db9MwFLW2ISReEN8ERuUHeMya1nZsP7ZVuwnRaZo21Lco_lqD2qRqikT_Fv-AP8Bv4tpJphXxxEvUj7h1dY97z7GO70Xoo6RUD_zOPRfKhK2bWBCq49w4k8Dfn266N8wv04tb-nnBFkeIdWdhgmlfq-KsXK3PymIZvJWbte53PrH-1XwCOVdC7uofo2NOSCfRW5VFgNA3DncCer5ffFvXXuQQyn3PnMAfEkEO0lCo1v8vivm3U_JB6pk9Q09bzohHzdyeoyNbvkCPmy6S-5foF6xxby23Bn_xFiBcOfy1NZjiaWn8GasVwAyfg-TeLfGsabGD1R7TeGl_7FcguautLspqhYsaz0P3Dvg0uOGm47WQ4Q7Hx79_DnBeGjzSGlKXrzhR40m-8V2Mtnt8be9CQWsfd1yUGOaAx_A7av-kseEUGo_KYg34f4VuZ9ObyUXcdmaINZGExExpAcyFJUSbJFHCH69ljjhneT5IGSNKplQzI-EhS42mhvGcJZAw-VDlwpHX6KSsSvsWYZoOlUtlbmE0tdrmTGoNsolaoZ2QaYQ-dYHKNk0BjgyEi49t9jC2ERr7KN7f48tmhxeq7V3WgifjQ51QboSSjlFFmaQO-K9MnUuFolJF6LTDQNau5ToDzgMaFqQpj9CbBg7339LBKUL8ACgH0zh8B0Adqni3IH733yPfoydDL_59KVl6ik522-_2AzCknerBulhwuIrZeQ89Gk8vr657Ybeh5zMXg-ucil5YN38AcT0bpw |
| link.rule.ids | 230,315,733,786,790,870,891,2115,2236,12083,12792,21416,24346,27957,27958,31754,33408,33779,43345,43635,43840,53827,53829,74102,74392,74659 |
| linkProvider | National Library of Medicine |
| linkToHtml | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwfV3JjtNAEG1BRgguiJ3AAHWAozWOe7H7hJJRQoAkQqMMmpvl3iZGGTvEQSK_xR_wA3wT1bYTJghx876oqrrea5frEfJaMqZ7fuY-TpSpp26ChDIdZMaZEIc_3ag3TGdifM4-XPCLdsKtassqd2NiPVCbUvs58hPMPMgkkCDEb1dfA68a5b-uthIaN8kRo0hVOuRoMJx9OttTLhrVcmk9zEKB4FI0pe8Uif5J_uWq8uyHspgeJKW6d_-_AOffdZPXEtHoHrnbIkjoNya_T27Y4gG51WhKbh-SnxjxvtDcGpj4giAoHXxuy01hWBj_x9USnQ7eIQHfLGDUCO6A2gILFvb7dokEvFzrvCiXkFcwrbU88Gp4wHyHcjHfHZ4f_PrRg6ww0NcaE5nvP1HBabbymkbrLZzZy7q9tfcCyAvAZ4ABvkflV5qinFxDv8ivMBoekfPRcH46DlqdhkBTSWnAlU4Qx_CQahOGKvE_23JHnbNx1hOcUyUF09xIXOTCaGZ4nPEQ02ccqSxx9DHpFGVhnxJgIlJOyMzi2cxqm3GpNZIoZhPtEim65M3OUOmqaceRIo3xBk2vG7RLBt6K-2N8E-16Q7m-TNuYTONIhyw2iZKOM8W4ZA7RsBTOiUQxqbrkeOcDaRvZVfrHD7vkSeMO-7vU4BQxbZfEB45y8BiHe4p8Uff0RhgpEY49-_8tX5Hb4_l0kk7ezz4-J3ciz_19J1l2TDqb9Tf7AgHSRr1so-A3Q4gSzA |
| linkToPdf | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwfV3JbtRAEG1BEIgLYschQB_gaI3Hvbj7hCYhToAkQihBuVnuLWM0sSfjQWJ-iz_gB_gmqtueIUaIm_dFVdX1XrtcD6HXklI99jP3mVAmTN3EglAdl8aZBIY_3ak3HJ_wwzP64Zyd9_VPbV9WuR4Tw0BtGu3nyEeQeYBJAEHIRq4vi_j0Ln87v4q9gpT_0trLadxEtzzI9moGIj_YkC-SBuG0MeSjmDPJuyJ4ApR_VH29bD0PIjQjg_QUuvj_C3r-XUF5LSXl99G9HkviSWf8B-iGrR-i25265OoR-gmx70vOrcFHvjQINw5_6QtP8X5t_L9XM3A_fABUfDnFeSe9g9UK03hqv69mQMWbha7qZoarFh8HVQ-4Ghxwusa7kPmG58e_foxxWRs80RpSmu9E0eK9cu7VjRYr_NlehEbX3h9wVWN4BrwL79H6la48p9J4UleXEBeP0Vm-f7p3GPeKDbEmkpCYKS0A0bCEaJMkSvjfbpkjztmsHHPGiJKcamYkLDJuNDUsK1kCiTRLVSkceYK26qa2zxCmPFWOy9LC2dRqWzKpNdApaoV2QvIIvVkbqph3jTkKIDTeoMV1g0Zo11txc4xvpx02NIuLoo_OIkt1QjMjlHSMKsokdYCLJXeOC0WlitDO2geKPsbb4o9HRuhp5w6buwSYCug2QtnAUQaPMdxTV9PQ3RsApQRgtv3_W75Cd8D9i6P3Jx-fo7upnwTwLWXpDtpaLr7ZF4CUluplCIHfXt8Vmw |
| openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Increased+Level+of+Vascular+Endothelial+Growth+Factors+by+4-hexylresorcinol+is+Mediated+by+Transforming+Growth+Factor-%CE%B21+and+Accelerates+Capillary+Regeneration+in+the+Burns+in+Diabetic+Animals&rft.jtitle=International+journal+of+molecular+sciences&rft.au=Dae-Won+Kim&rft.au=You-Young+Jo&rft.au=Umberto+Garagiola&rft.au=Je-Yong+Choi&rft.date=2020-05-14&rft.pub=MDPI+AG&rft.issn=1661-6596&rft.eissn=1422-0067&rft.volume=21&rft.issue=10&rft.spage=3473&rft_id=info:doi/10.3390%2Fijms21103473&rft.externalDBID=DOA&rft.externalDocID=oai_doaj_org_article_72c047d8b9f54b4594f97796ff68b49b |
| thumbnail_l | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=1422-0067&client=summon |
| thumbnail_m | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=1422-0067&client=summon |
| thumbnail_s | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=1422-0067&client=summon |