Asymmetric Dimethylarginine and Reactive Oxygen Species: Unwelcome Twin Visitors to the Cardiovascular and Kidney Disease Tables

• Published in: Hypertension (Dallas, Tex. 1979) Vol. 59; no. 2 Suppl 1; pp. 375 - 381
• Main Author: Wilcox, Christopher S.
• Format: Journal Article
• Language: English
• Published: Hagerstown, MD American Heart Association, Inc 01.02.2012; Lippincott Williams & Wilkins
• Subjects: Animals; Arginine - analogs & derivatives; Arginine - metabolism; Arterial hypertension. Arterial hypotension; Biological and medical sciences; Blood and lymphatic vessels; Cardiology. Vascular system; Cardiovascular Diseases - epidemiology; Cardiovascular Diseases - metabolism; Cardiovascular Diseases - physiopathology; Disease Models, Animal; Endothelium, Vascular - physiopathology; Experimental diseases; Humans; Kidney Diseases - epidemiology; Kidney Diseases - metabolism; Kidney Diseases - physiopathology; Medical sciences; Rats; Reactive Oxygen Species - metabolism; Risk Factors; Hypertension; NADPH; Kidney disease; endothelial function; NO; Oxygen; Urinary system disease; Enzyme; Peptide hormone; Oxidase; Cardiovascular disease; Twin; Octapeptide; NADPH oxidase; Oxidoreductases; Angiotensin II

Plasma levels of asymmetric dimethylarginine or markers of reactive oxygen species are increased in subjects with risk factors for cardiovascular disease or chronic kidney disease. We tested the hypothesis that reactive oxygen species generate cellular asymmetric dimethylarginine that together cause...