New 1,4‐Dihydropyridines Down‐regulate Nitric Oxide in Animals with Streptozotocin‐induced Diabetes Mellitus and Protect Deoxyribonucleic Acid against Peroxynitrite Action

• Published in: Basic & clinical pharmacology & toxicology Vol. 119; no. 1; pp. 19 - 31
• Main Authors: Leonova, Elina, Sokolovska, Jelizaveta, Boucher, Jean‐Luc, Isajevs, Sergejs, Rostoka, Evita, Baumane, Larisa, Sjakste, Tatjana, Sjakste, Nikolajs
• Format: Journal Article
• Language: English
• Published: England Wiley Subscription Services, Inc 01.07.2016
• Subjects: Animals; Blood Glucose - metabolism; Deoxyribonucleic acid; Diabetes; Diabetes Mellitus, Experimental - drug therapy; Dihydropyridines - pharmacology; DNA; DNA - chemistry; Down-Regulation; Kidney - drug effects; Kidney - metabolism; Liver - drug effects; Liver - metabolism; Male; Nitric oxide; Nitric Oxide - metabolism; Nitric Oxide Synthase Type II - antagonists & inhibitors; Nitric Oxide Synthase Type II - metabolism; Nitric Oxide Synthase Type III - antagonists & inhibitors; Nitric Oxide Synthase Type III - metabolism; Peroxynitrous Acid - chemistry; Protective Agents - pharmacology; Rats; Rats, Wistar; Reactive Nitrogen Species - metabolism; Reactive Oxygen Species - metabolism; Rodents; Xanthine Dehydrogenase - antagonists & inhibitors; Xanthine Dehydrogenase - metabolism

Diabetes mellitus (DM) and its complications cause numerous health and social problems throughout the world. Pathogenic actions of nitric oxide (NO) are responsible to a large extent for development of complications of DM. Search for compounds regulating NO production in patients with DM is thus imp...