Insight into the pediatric and adult dichotomy of COVID‐19: Age‐related differences in the immune response to SARS‐CoV‐2 infection

• Published in: Pediatric pulmonology Vol. 55; no. 10; pp. 2556 - 2564
• Main Authors: Fialkowski, Allison, Gernez, Yael, Arya, Puneeta, Weinacht, Katja G., Kinane, T. Bernard, Yonker, Lael M.
• Format: Journal Article
• Language: English
• Published: United States Wiley Subscription Services, Inc 01.10.2020
• Subjects: Adaptive Immunity; Adult; age‐related immune response; Aging - immunology; Child; childhood COVID‐19; Coronaviruses; COVID-19 - immunology; Humans; Immunity, Innate; Multisystem inflammatory syndrome in children; pediatric COVID‐19; Pediatrics; SARS-CoV-2 - physiology; SARS‐CoV‐2 infection; Severe acute respiratory syndrome coronavirus 2; Systemic Inflammatory Response Syndrome - immunology; Virus Internalization; SARS-CoV-2 infection; age-related immune response; childhood COVID-19; pediatric COVID-19

The difference in morbidity and mortality between adult and pediatric coronavirus disease 2019 infections is dramatic. Understanding pediatric‐specific acute and delayed immune responses to severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) is critical for the development of vaccination st...