Association of periodontitis with tinnitus: A population‐based cohort study in Taiwan

Aim Tinnitus, ringing in the ears, is speculated to be driven by inflammation. This study examined whether periodontitis is a risk factor for tinnitus using Taiwan's National Health Insurance Research Database. Materials and Methods Among the 79,456 patients who visited for dental concerns, 11,...

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Published inJournal of clinical periodontology Vol. 49; no. 10; pp. 970 - 979
Main Authors Su, Suzanne Ying‐Shan, Chien, Wu‐Chien, Chung, Chi‐Hsiang, Su, Wan‐Fu, Fu, Earl
Format Journal Article
LanguageEnglish
Published Oxford, UK Blackwell Publishing Ltd 01.10.2022
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Abstract Aim Tinnitus, ringing in the ears, is speculated to be driven by inflammation. This study examined whether periodontitis is a risk factor for tinnitus using Taiwan's National Health Insurance Research Database. Materials and Methods Among the 79,456 patients who visited for dental concerns, 11,055 patients who were diagnosed with periodontitis and underwent periodontal treatment between 2000 and 2015 were enrolled in Group 1. After matching for sex, age, and index year, 11,055 patients with periodontitis who received no treatment were enrolled in Group 2. Similarly, 11,055 participants without periodontitis were included as controls. Results At the end of the follow‐up, 412 and 404 participants in the two periodontitis groups and 321 participants in the control group had tinnitus. Cumulative risk for tinnitus in Group 1 or 2 was significantly greater than in the control group. More periodontitis patients than controls developed tinnitus (adjusted hazard ratios were 1.71 (95% confidence interval [CI]: 1.49–1.97, p < .001) and 1.64 (95% CI: 1.37–1.86, p < .001) in Groups 1 and 2, respectively). The risks were not significantly different between Groups 1 and 2. Similar findings were obtained after excluding data for the first 1 or 5 years. Conclusions The study findings indicate that periodontitis is associated with tinnitus.
AbstractList Aim Tinnitus, ringing in the ears, is speculated to be driven by inflammation. This study examined whether periodontitis is a risk factor for tinnitus using Taiwan's National Health Insurance Research Database. Materials and Methods Among the 79,456 patients who visited for dental concerns, 11,055 patients who were diagnosed with periodontitis and underwent periodontal treatment between 2000 and 2015 were enrolled in Group 1. After matching for sex, age, and index year, 11,055 patients with periodontitis who received no treatment were enrolled in Group 2. Similarly, 11,055 participants without periodontitis were included as controls. Results At the end of the follow‐up, 412 and 404 participants in the two periodontitis groups and 321 participants in the control group had tinnitus. Cumulative risk for tinnitus in Group 1 or 2 was significantly greater than in the control group. More periodontitis patients than controls developed tinnitus (adjusted hazard ratios were 1.71 (95% confidence interval [CI]: 1.49–1.97, p < .001) and 1.64 (95% CI: 1.37–1.86, p < .001) in Groups 1 and 2, respectively). The risks were not significantly different between Groups 1 and 2. Similar findings were obtained after excluding data for the first 1 or 5 years. Conclusions The study findings indicate that periodontitis is associated with tinnitus.
AIMTinnitus, ringing in the ears, is speculated to be driven by inflammation. This study examined whether periodontitis is a risk factor for tinnitus using Taiwan's National Health Insurance Research Database. MATERIALS AND METHODSAmong the 79,456 patients who visited for dental concerns, 11,055 patients who were diagnosed with periodontitis and underwent periodontal treatment between 2000 and 2015 were enrolled in Group 1. After matching for sex, age, and index year, 11,055 patients with periodontitis who received no treatment were enrolled in Group 2. Similarly, 11,055 participants without periodontitis were included as controls. RESULTSAt the end of the follow-up, 412 and 404 participants in the two periodontitis groups and 321 participants in the control group had tinnitus. Cumulative risk for tinnitus in Group 1 or 2 was significantly greater than in the control group. More periodontitis patients than controls developed tinnitus (adjusted hazard ratios were 1.71 (95% confidence interval [CI]: 1.49-1.97, p < .001) and 1.64 (95% CI: 1.37-1.86, p < .001) in Groups 1 and 2, respectively). The risks were not significantly different between Groups 1 and 2. Similar findings were obtained after excluding data for the first 1 or 5 years. CONCLUSIONSThe study findings indicate that periodontitis is associated with tinnitus.
Tinnitus, ringing in the ears, is speculated to be driven by inflammation. This study examined whether periodontitis is a risk factor for tinnitus using Taiwan's National Health Insurance Research Database. Among the 79,456 patients who visited for dental concerns, 11,055 patients who were diagnosed with periodontitis and underwent periodontal treatment were enrolled between 2000 and 2015 as Group 1. After matching for sex, age, and index year, 11,055 patients with periodontitis who received no treatment were enrolled as Group 2. Similarly, 11,055 participants without periodontitis were included as controls. At the end of follow-up, 412 and 404 participants in the two periodontitis groups and 321 participants in the control group had tinnitus. Cumulative risk for tinnitus in Group 1 or 2 was significantly greater than in the control group. More periodontitis patients than controls developed tinnitus (adjusted hazard ratios were 1.71 (95% CI: 1.49-1.97, p<0.001) and 1.64 (95% CI: 1.37-1.86, p<0.001) in Groups 1 and 2, respectively). The risks were not significantly different between Groups 1 and 2. Similar findings were obtained after excluding data for the first 1 or 5 years. The study findings indicate that periodontitis is associated with tinnitus.
Author Su, Wan‐Fu
Chien, Wu‐Chien
Su, Suzanne Ying‐Shan
Chung, Chi‐Hsiang
Fu, Earl
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Tri‐Service General Hospital Research Foundation, Grant/Award Number: TSGH‐B‐111018
Earl Fu and Wu‐Chien Chien contributed equally to this work.
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Snippet Aim Tinnitus, ringing in the ears, is speculated to be driven by inflammation. This study examined whether periodontitis is a risk factor for tinnitus using...
Tinnitus, ringing in the ears, is speculated to be driven by inflammation. This study examined whether periodontitis is a risk factor for tinnitus using...
AimTinnitus, ringing in the ears, is speculated to be driven by inflammation. This study examined whether periodontitis is a risk factor for tinnitus using...
AIMTinnitus, ringing in the ears, is speculated to be driven by inflammation. This study examined whether periodontitis is a risk factor for tinnitus using...
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pubmed
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SubjectTerms Cohort analysis
Gum disease
national health programmes
otologic diseases
Patients
Periodontitis
Population studies
Population-based studies
Risk factors
Tinnitus
Title Association of periodontitis with tinnitus: A population‐based cohort study in Taiwan
URI https://onlinelibrary.wiley.com/doi/abs/10.1111%2Fjcpe.13670
https://www.ncbi.nlm.nih.gov/pubmed/35634696
https://www.proquest.com/docview/2715684246
https://search.proquest.com/docview/2671996463
Volume 49
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