Cancer metastasis: Mechanisms of inhibition by melatonin
Melatonin is a naturally occurring molecule secreted by the pineal gland and known as a gatekeeper of circadian clocks. Mounting evidence indicates that melatonin, employing multiple and interrelated mechanisms, exhibits a variety of oncostatic properties in a myriad of tumors during different stage...
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| Published in | Journal of pineal research Vol. 62; no. 1; pp. np - n/a |
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| Main Authors | , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
England
01.01.2017
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| Subjects | |
| Online Access | Get full text |
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| Abstract | Melatonin is a naturally occurring molecule secreted by the pineal gland and known as a gatekeeper of circadian clocks. Mounting evidence indicates that melatonin, employing multiple and interrelated mechanisms, exhibits a variety of oncostatic properties in a myriad of tumors during different stages of their progression. Tumor metastasis, which commonly occurs at the late stage, is responsible for the majority of cancer deaths; metastases lead to the development of secondary tumors distant from a primary site. In reference to melatonin, the vast majority of investigations have focused on tumor development and progression at the primary site. Recently, however, interest has shifted toward the role of melatonin on tumor metastases. In this review, we highlight current advances in understanding the molecular mechanisms by which melatonin counteracts tumor metastases, including experimental and clinical observations; emphasis is placed on the impact of both cancer and non‐neoplastic cells within the tumor microenvironment. Due to the broad range of melatonin's actions, the mechanisms underlying its ability to interfere with metastases are numerous. These include modulation of cell–cell and cell–matrix interaction, extracellular matrix remodeling by matrix metalloproteinases, cytoskeleton reorganization, epithelial–mesenchymal transition, and angiogenesis. The evidence discussed herein will serve as a solid foundation for urging basic and clinical studies on the use of melatonin to understand and control metastatic diseases. |
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| AbstractList | Melatonin is a naturally occurring molecule secreted by the pineal gland and known as a gatekeeper of circadian clocks. Mounting evidence indicates that melatonin, employing multiple and interrelated mechanisms, exhibits a variety of oncostatic properties in a myriad of tumors during different stages of their progression. Tumor metastasis, which commonly occurs at the late stage, is responsible for the majority of cancer deaths; metastases lead to the development of secondary tumors distant from a primary site. In reference to melatonin, the vast majority of investigations have focused on tumor development and progression at the primary site. Recently, however, interest has shifted toward the role of melatonin on tumor metastases. In this review, we highlight current advances in understanding the molecular mechanisms by which melatonin counteracts tumor metastases, including experimental and clinical observations; emphasis is placed on the impact of both cancer and non‐neoplastic cells within the tumor microenvironment. Due to the broad range of melatonin's actions, the mechanisms underlying its ability to interfere with metastases are numerous. These include modulation of cell–cell and cell–matrix interaction, extracellular matrix remodeling by matrix metalloproteinases, cytoskeleton reorganization, epithelial–mesenchymal transition, and angiogenesis. The evidence discussed herein will serve as a solid foundation for urging basic and clinical studies on the use of melatonin to understand and control metastatic diseases. |
| Author | Chung, Wen‐Hung Su, Shih‐Chi Yang, Wei‐En Hsieh, Ming‐Ju Reiter, Russel J. Yang, Shun‐Fa |
| Author_xml | – sequence: 1 givenname: Shih‐Chi surname: Su fullname: Su, Shih‐Chi organization: Chang Gung Memorial Hospital – sequence: 2 givenname: Ming‐Ju surname: Hsieh fullname: Hsieh, Ming‐Ju organization: China Medical University – sequence: 3 givenname: Wei‐En surname: Yang fullname: Yang, Wei‐En organization: Chung Shan Medical University Hospital – sequence: 4 givenname: Wen‐Hung surname: Chung fullname: Chung, Wen‐Hung organization: Chang Gung University – sequence: 5 givenname: Russel J. surname: Reiter fullname: Reiter, Russel J. organization: The University of Texas Health Science Center – sequence: 6 givenname: Shun‐Fa surname: Yang fullname: Yang, Shun‐Fa email: ysf@csmu.edu.tw organization: Chung Shan Medical University Hospital |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/27706852$$D View this record in MEDLINE/PubMed |
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| Cites_doi | 10.1111/j.1600-079X.1993.tb00498.x 10.1111/j.1600-079X.2010.00812.x 10.1186/bcr2794 10.1111/jpi.12330 10.1111/jpi.12196 10.1111/cpr.12158 10.18632/oncotarget.8009 10.1152/physiol.00011.2014 10.1111/jpi.12365 10.1096/fj.03-0694fje 10.1172/JCI43424 10.1111/jpi.12224 10.1111/j.1600-079X.2011.00856.x 10.1385/ENDO:27:2:119 10.1111/j.1600-079X.2005.00258.x 10.1016/j.cell.2011.02.013 10.1016/S0092-8674(02)00971-6 10.1038/nrc2618 10.1111/jpi.12034 10.1111/jpi.12267 10.1111/jpi.12221 10.1038/nrc2621 10.1016/S0021-9258(19)61934-4 10.1371/journal.pone.0101132 10.1038/nrm3904 10.1158/0008-5472.CAN-06-2407 10.1210/me.2012-1071 10.1155/2012/743193 10.1517/14728222.2016.1091882 10.18632/oncotarget.8776 10.1016/S1043-2760(02)00010-3 10.1021/ja01543a060 10.1038/nrm3758 10.1016/j.stem.2014.02.002 10.1038/ncb1559 10.1517/14728222.2013.834890 10.1074/jbc.M202421200 10.1111/jpi.12240 10.2174/092986710791233689 10.1111/bph.12704 10.3892/or.2015.4238 10.1016/S0165-6147(00)01676-X 10.1111/j.1600-079X.2011.00909.x 10.1007/s00018-014-1579-2 10.1038/sj.onc.1208429 10.1186/s12967-015-0454-8 10.1038/nrc865 10.1007/s00432-011-1024-y 10.1111/jpi.12302 10.1111/j.1600-079X.2011.00931.x 10.2478/v10102-010-0030-2 10.1007/s00005-015-0382-6 10.1111/jpi.12270 10.1385/ENDO:27:2:201 10.1016/j.bcmd.2007.04.001 10.1111/jpi.12348 10.1111/j.1600-079X.2004.00141.x 10.1111/j.1600-079X.2011.00934.x 10.1038/nrc1693 10.1111/jpi.12227 10.1530/ERC-15-0030 10.1111/jpi.12226 10.1016/j.pneurobio.2010.12.004 10.1016/j.smrv.2004.05.002 10.1038/35036374 10.1038/sj.onc.1201012 10.1016/j.canlet.2009.06.016 10.1080/15384101.2015.1063296 10.1158/1541-7786.MCR-16-0158 10.1007/s10555-008-9166-3 10.1038/nrc3125 10.7150/jca.9591 10.1111/j.1600-079X.2007.00496.x 10.2174/092986710794183015 10.1016/S0002-9440(10)64807-9 10.1158/0008-5472.CAN-07-2938 10.1016/j.bbcan.2016.02.004 10.1126/science.1234850 10.1111/jpi.12295 10.1016/S1097-2765(01)00260-X 10.1016/S0021-9258(18)53979-X 10.1074/jbc.270.13.7037 10.1111/jpi.12308 10.1016/j.devcel.2009.12.008 10.1111/j.1600-079X.2009.00727.x 10.1111/j.1600-079X.2008.00600.x 10.1002/(SICI)1097-0215(20000415)86:2<188::AID-IJC7>3.0.CO;2-W 10.1128/MCB.24.1.306-319.2004 10.18632/genesandcancer.107 10.1111/jpi.12026 10.1016/S0959-8049(00)00158-1 10.1016/j.bbamem.2008.11.005 10.1111/j.1600-079X.2007.00513.x 10.1038/nm1469 10.1016/j.molmed.2011.01.015 10.2174/13816128113199990590 10.1038/sj.onc.1209808 10.1016/j.mvr.2013.02.008 10.1016/S0065-230X(09)02003-X 10.1007/s10555-006-7886-9 10.3390/ijms151223448 10.1371/journal.pone.0150407 10.1002/(SICI)1097-4644(19970601)65:3<430::AID-JCB12>3.0.CO;2-J 10.1007/BF01923944 10.1038/nrm757 10.1016/S0304-419X(01)00038-5 10.1111/jpi.12052 10.1016/j.mod.2003.06.005 10.1074/jbc.M403140200 10.1111/jpi.12360 10.1211/002235702760345374 10.1073/pnas.1208324109 10.1172/JCI38019 10.1016/j.cell.2009.11.007 10.1111/j.1600-079X.2012.01030.x 10.3109/07853890.2011.586365 10.2174/138161209788453275 10.1126/science.1164853 10.1111/j.1600-079X.2004.00165.x 10.1242/jcs.100115 10.1002/jcb.21695 10.1158/1078-0432.CCR-04-1995 10.1111/jpi.12131 10.1152/ajpcell.00145.2015 10.1016/j.ajpath.2011.07.011 10.1128/MCB.00323-08 10.1158/0008-5472.CAN-06-1776 10.1002/path.2727 10.1016/j.stem.2008.09.013 10.2174/1871520614666140812110246 10.1242/jcs.02552 10.1111/jpi.12257 10.1530/JOE-12-0147 10.1016/S0165-5728(98)00179-9 10.1016/j.mce.2012.01.004 10.1016/S0079-6123(08)81008-4 10.1186/s40169-015-0048-3 |
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| Keywords | matrix metalloproteinase epithelial-mesenchymal transition melatonin metastasis angiogenesis |
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| References | 2010; 12 2010; 18 2010; 17 2010; 227 2013; 126 2010; 222 2004; 24 2000; 86 2002; 277 2015; 309 2008; 104 2010; 181 2014; 29 2011; 58 2009; 119 2014; 20 1994; 269 2013; 55 2013; 54 2004; 37 2006; 25 2008; 28 2014; 15 2007; 9 2014; 14 1998; 92 2012; 26 2009; 15 2011; 137 2015; 59 2015; 58 1993; 49 2013; 87 2005; 118 2002; 2 2013; 342 2002; 3 2001; 22 2012; 32 2016; 14 1995; 270 2012; 109 2016; 11 2012; 351 2016; 7 2010; 48 2004; 279 2005; 9 2011; 93 2005; 5 2016; 20 2009; 102 2008; 44 2012; 44 2005; 11 2011; 144 2007; 39 2015; 34 2009; 46 2012; 2012 2002; 110 2002; 54 2003; 14 2011; 11 2000; 2 2008; 3 2014; 171 2008; 1 2011; 17 2005; 27 2012; 52 2005; 24 2015; 48 2013; 17 2006; 66 1997; 14 2008; 68 1999; 10 1958; 80 2014; 9 2012; 214 2005; 39 2014; 56 1998; 58 2003; 120 2007; 26 2015; 13 2009; 1788 2011; 179 2015; 14 2015; 6 2015; 4 2000; 157 2006; 12 1997; 65 2016; 1865 2010; 120 1993; 268 2008; 321 2009; 28 2009; 139 1993; 14 2004; 18 2000; 36 2001; 7 2011; 51 2015; 22 2011; 50 2016; 64 2009; 9 2016; 61 2016; 60 2007; 43 2014; 71 2001; 1552 e_1_2_7_108_1 e_1_2_7_3_1 e_1_2_7_104_1 e_1_2_7_127_1 e_1_2_7_7_1 e_1_2_7_19_1 e_1_2_7_60_1 e_1_2_7_83_1 e_1_2_7_100_1 e_1_2_7_123_1 e_1_2_7_15_1 e_1_2_7_41_1 e_1_2_7_64_1 e_1_2_7_87_1 e_1_2_7_11_1 e_1_2_7_45_1 e_1_2_7_68_1 e_1_2_7_26_1 e_1_2_7_49_1 e_1_2_7_142_1 e_1_2_7_90_1 e_1_2_7_112_1 e_1_2_7_94_1 e_1_2_7_71_1 e_1_2_7_52_1 e_1_2_7_98_1 e_1_2_7_23_1 e_1_2_7_33_1 e_1_2_7_75_1 e_1_2_7_56_1 Lissoni P (e_1_2_7_116_1) 2001; 22 e_1_2_7_37_1 e_1_2_7_79_1 e_1_2_7_131_1 e_1_2_7_135_1 e_1_2_7_139_1 e_1_2_7_109_1 e_1_2_7_4_1 e_1_2_7_128_1 e_1_2_7_105_1 e_1_2_7_8_1 e_1_2_7_124_1 e_1_2_7_16_1 e_1_2_7_40_1 e_1_2_7_82_1 e_1_2_7_120_1 e_1_2_7_63_1 e_1_2_7_12_1 e_1_2_7_44_1 e_1_2_7_86_1 e_1_2_7_67_1 e_1_2_7_29_1 e_1_2_7_117_1 e_1_2_7_113_1 e_1_2_7_51_1 e_1_2_7_70_1 e_1_2_7_93_1 e_1_2_7_24_1 e_1_2_7_32_1 e_1_2_7_55_1 e_1_2_7_74_1 e_1_2_7_97_1 e_1_2_7_20_1 e_1_2_7_36_1 e_1_2_7_78_1 e_1_2_7_132_1 e_1_2_7_136_1 e_1_2_7_5_1 e_1_2_7_106_1 e_1_2_7_129_1 e_1_2_7_9_1 e_1_2_7_102_1 e_1_2_7_125_1 e_1_2_7_17_1 e_1_2_7_62_1 e_1_2_7_81_1 e_1_2_7_121_1 e_1_2_7_13_1 e_1_2_7_43_1 e_1_2_7_66_1 e_1_2_7_85_1 e_1_2_7_47_1 e_1_2_7_89_1 e_1_2_7_140_1 e_1_2_7_28_1 Farina AR (e_1_2_7_107_1) 1999; 10 e_1_2_7_118_1 e_1_2_7_114_1 e_1_2_7_73_1 e_1_2_7_110_1 e_1_2_7_50_1 e_1_2_7_92_1 e_1_2_7_25_1 e_1_2_7_31_1 e_1_2_7_77_1 e_1_2_7_54_1 e_1_2_7_96_1 Cos S (e_1_2_7_59_1) 1998; 58 e_1_2_7_21_1 e_1_2_7_35_1 e_1_2_7_58_1 e_1_2_7_39_1 e_1_2_7_133_1 e_1_2_7_137_1 e_1_2_7_6_1 Lilienbaum A (e_1_2_7_101_1) 1993; 268 e_1_2_7_80_1 e_1_2_7_126_1 e_1_2_7_103_1 e_1_2_7_18_1 e_1_2_7_84_1 e_1_2_7_122_1 e_1_2_7_61_1 e_1_2_7_2_1 e_1_2_7_14_1 e_1_2_7_42_1 e_1_2_7_88_1 e_1_2_7_65_1 e_1_2_7_10_1 e_1_2_7_46_1 e_1_2_7_69_1 e_1_2_7_141_1 e_1_2_7_27_1 e_1_2_7_119_1 e_1_2_7_91_1 e_1_2_7_115_1 e_1_2_7_72_1 e_1_2_7_95_1 e_1_2_7_111_1 e_1_2_7_30_1 e_1_2_7_53_1 e_1_2_7_76_1 e_1_2_7_99_1 e_1_2_7_22_1 e_1_2_7_34_1 e_1_2_7_57_1 e_1_2_7_130_1 e_1_2_7_38_1 e_1_2_7_134_1 Cutando A (e_1_2_7_48_1) 2012; 32 e_1_2_7_138_1 |
| References_xml | – volume: 92 start-page: 76 year: 1998 end-page: 84 article-title: Involvement of nuclear binding sites for melatonin in the regulation of IL‐2 and IL‐6 production by human blood mononuclear cells publication-title: J Neuroimmunol – volume: 66 start-page: 11089 year: 2006 end-page: 11093 article-title: Preparing the “soil”: the premetastatic niche publication-title: Cancer Res – volume: 80 start-page: 2587 year: 1958 article-title: Isolation of melatonin, the pineal factor that lightens melanocytes publication-title: J Amer Chem Soc – volume: 59 start-page: 403 year: 2015 end-page: 419 article-title: Melatonin: an ancient molecule that makes oxygen metabolically tolerable publication-title: J Pineal Res – volume: 52 start-page: 217 year: 2012 end-page: 227 article-title: Extrapineal melatonin: analysis of its subcellular distribution and daily fluctuations publication-title: J Pineal Res – volume: 13 start-page: 95 year: 2015 article-title: Involvement of ROS‐alpha v beta 3 integrin‐FAK/Pyk2 in the inhibitory effect of melatonin on U251 glioma cell migration and invasion under hypoxia publication-title: J Transl Med – volume: 7 start-page: 21952 year: 2016 end-page: 21967 article-title: Melatonin inhibits TPA‐induced oral cancer cell migration by suppressing matrix metalloproteinase‐9 activation through the histone acetylation publication-title: Oncotarget – volume: 10 start-page: 353 year: 1999 end-page: 367 article-title: Transcriptional up‐regulation of matrix metalloproteinase‐9 expression during spontaneous epithelial to neuroblast phenotype conversion by SK‐N‐SH neuroblastoma cells, involved in enhanced invasivity, depends upon GT‐box and nuclear factor kappaB elements publication-title: Cell Growth Differ – volume: 49 start-page: 635 year: 1993 end-page: 641 article-title: Calmodulin mediates melatonin cytoskeletal effects publication-title: Experientia – volume: 27 start-page: 201 year: 2005 end-page: 212 article-title: Melatonin, aging, and age‐related diseases: perspectives for prevention, intervention and therapy publication-title: Endocrine – volume: 227 start-page: 216 year: 2010 end-page: 223 article-title: Melatonin sensitizes human malignant glioma cells against TRAIL‐induced cell death publication-title: Cancer Lett – volume: 277 start-page: 27850 year: 2002 end-page: 27855 article-title: Endothelin‐1 induces vascular endothelial growth factor by increasing hypoxia‐inducible factor‐1alpha in ovarian carcinoma cells publication-title: J Biol Chem – volume: 179 start-page: 2559 year: 2011 end-page: 2568 article-title: Integrin alphav expression is required for the acquisition of a metastatic stem/progenitor cell phenotype in human prostate cancer publication-title: Am J Pathol – volume: 7 start-page: 209 year: 2016 end-page: 217 article-title: Melatonin decreases estrogen receptor binding to estrogen response elements sites on the OCT4 gene in human breast cancer stem cells publication-title: Genes Cancer – volume: 54 start-page: 127 year: 2013 end-page: 138 article-title: Mitochondria and chloroplasts as the original sites of melatonin synthesis: a hypothesis related to melatonin's primary function and evolution in eukaryotes publication-title: J Pineal Res – volume: 15 start-page: 1854 year: 2009 end-page: 1867 article-title: Angiogenesis: complexity of tumor vasculature and microenvironment publication-title: Curr Pharm Des – volume: 86 start-page: 188 year: 2000 end-page: 196 article-title: bcl‐2 over‐expression enhances NF‐kappaB activity and induces mmp‐9 transcription in human MCF7(ADR) breast‐cancer cells publication-title: Int J Cancer – volume: 157 start-page: 1703 year: 2000 end-page: 1711 article-title: Endothelin‐1 induces an angiogenic phenotype in cultured endothelial cells and stimulates neovascularization in vivo publication-title: Am J Pathol – volume: 56 start-page: 415 year: 2014 end-page: 426 article-title: Melatonin reduces endothelin‐1 expression and secretion in colon cancer cells through the inactivation of FoxO‐1 and NF‐kappabeta publication-title: J Pineal Res – volume: 58 start-page: 4383 year: 1998 end-page: 4390 article-title: Influence of melatonin on invasive and metastatic properties of MCF‐7 human breast cancer cells publication-title: Cancer Res – volume: 59 start-page: 1 year: 2015 end-page: 23 article-title: Experimental and clinical aspects of melatonin and clock genes in diabetes publication-title: J Pineal Res – volume: 61 start-page: 479 year: 2016 end-page: 492 article-title: Melatonin suppresses TPA‐induced metastasis by downregulating matrix metalloproteinase‐9 expression through JNK/SP‐1 signaling in nasopharyngeal carcinoma publication-title: J Pineal Res – volume: 12 start-page: 895 year: 2006 end-page: 904 article-title: Tumor metastasis: mechanistic insights and clinical challenges publication-title: Nat Med – volume: 46 start-page: 15 year: 2009 end-page: 21 article-title: ROCK‐regulated cytoskeletal dynamics participate in the inhibitory effect of melatonin on cancer cell migration publication-title: J Pineal Res – volume: 119 start-page: 1438 year: 2009 end-page: 1449 article-title: Epithelial‐mesenchymal transitions: the importance of changing cell state in development and disease publication-title: J Clin Invest – volume: 118 start-page: 4325 year: 2005 end-page: 4326 article-title: Epithelial‐mesenchymal transition publication-title: J Cell Sci – volume: 279 start-page: 38294 year: 2004 end-page: 38302 article-title: Melatonin, an endogenous‐specific inhibitor of estrogen receptor alpha via calmodulin publication-title: J Biol Chem – volume: 64 start-page: 259 year: 2016 end-page: 278 article-title: Novel Insights into the Roles of Rho Kinase in Cancer publication-title: Arch Immunol Ther Exp (Warsz) – volume: 17 start-page: 2070 year: 2010 end-page: 2095 article-title: Clinical uses of melatonin: evaluation of human trials publication-title: Curr Med Chem – volume: 61 start-page: 253 year: 2016 end-page: 278 article-title: Melatonin as an antioxidant: under promises but over delivers publication-title: J Pineal Res – volume: 87 start-page: 25 year: 2013 end-page: 33 article-title: Antiangiogenic effects of melatonin in endothelial cell cultures publication-title: Microvasc Res – volume: 222 start-page: 1 year: 2010 end-page: 15 article-title: Current and emerging concepts in tumour metastasis publication-title: J Pathol – volume: 68 start-page: 3645 year: 2008 end-page: 3654 article-title: Loss of E‐cadherin promotes metastasis via multiple downstream transcriptional pathways publication-title: Cancer Res – volume: 9 start-page: 285 year: 2009 end-page: 293 article-title: The metastatic niche: adapting the foreign soil publication-title: Nat Rev Cancer – volume: 1552 start-page: 39 year: 2001 end-page: 45 article-title: Cell adhesion in tumor invasion and metastasis: loss of the glue is not enough publication-title: Biochim Biophys Acta – volume: 93 start-page: 350 year: 2011 end-page: 389 article-title: Melatonin – a pleiotropic, orchestrating regulator molecule publication-title: Prog Neurobiol – volume: 15 start-page: 23448 year: 2014 end-page: 23500 article-title: Protecting the melatonin rhythm through circadian healthy light exposure publication-title: Int J Mol Sci – volume: 2012 start-page: 743193 year: 2012 article-title: The HER2 receptor in breast cancer: pathophysiology, clinical use, and new advances in therapy publication-title: Chemother Res Pract – volume: 71 start-page: 2997 year: 2014 end-page: 3025 article-title: Extrapineal melatonin: sources, regulation, and potential functions publication-title: Cell Mol Life Sci – volume: 110 start-page: 673 year: 2002 end-page: 687 article-title: Integrins: bidirectional, allosteric signaling machines publication-title: Cell – volume: 7 start-page: 46768 year: 2016 end-page: 46784 article-title: Melatonin as a potential anticarcinogen for non‐small‐cell lung cancer publication-title: Oncotarget – volume: 14 start-page: 2387 year: 2015 end-page: 2388 article-title: The forces behind EMT and tumor metastasis publication-title: Cell Cycle – volume: 3 start-page: 155 year: 2002 end-page: 166 article-title: The snail superfamily of zinc‐finger transcription factors publication-title: Nat Rev Mol Cell Biol – volume: 342 start-page: 1234850 year: 2013 article-title: Epithelial plasticity: a common theme in embryonic and cancer cells publication-title: Science – volume: 17 start-page: 1483 year: 2013 end-page: 1496 article-title: Molecular mechanisms of the pro‐apoptotic actions of melatonin in cancer: a review publication-title: Expert Opin Ther Targets – volume: 1788 start-page: 872 year: 2009 end-page: 891 article-title: Loss of tight junction barrier function and its role in cancer metastasis publication-title: Biochim Biophys Acta – volume: 48 start-page: 67 year: 2015 end-page: 77 article-title: Melatonin potentiates cisplatin‐induced apoptosis and cell cycle arrest in human long adenocarinoma cells publication-title: Cell Prolif – volume: 54 start-page: 398 year: 2013 end-page: 405 article-title: Melatonin inhibits matrix metalloproteinase‐9 activity by binding to its active site publication-title: J Pineal Res – volume: 11 start-page: 735 year: 2011 end-page: 748 article-title: Unravelling the complexity of metastasis ‐ molecular understanding and targeted therapies publication-title: Nat Rev Cancer – volume: 268 start-page: 2180 year: 1993 end-page: 2188 article-title: Activation of the human vimentin gene by the Tax human T‐cell leukemia virus. I. Mechanisms of regulation by the NF‐kappa B transcription factor publication-title: J Biol Chem – volume: 181 start-page: 127 year: 2010 end-page: 151 article-title: Melatonin: a multitasking molecule publication-title: Prog Brain Res – volume: 14 start-page: 1302 year: 2014 end-page: 1311 article-title: Molecular markers of angiogenesis and metastasis in lines of oral carcinoma after treatment with melatonin publication-title: Anticancer Agents Med Chem – volume: 102 start-page: 67 year: 2009 end-page: 101 article-title: Tumor dormancy and metastasis publication-title: Adv Cancer Res – volume: 24 start-page: 2375 year: 2005 end-page: 2385 article-title: DeltaEF1 is a transcriptional repressor of E‐cadherin and regulates epithelial plasticity in breast cancer cells publication-title: Oncogene – volume: 50 start-page: 8 year: 2011 end-page: 20 article-title: Matrix metalloproteinases in health and disease: regulation by melatonin publication-title: J Pineal Res – volume: 39 start-page: 360 year: 2005 end-page: 366 article-title: Melatonin in the treatment of cancer: a systematic review of randomized controlled trials and meta‐analysis publication-title: J Pineal Res – volume: 58 start-page: 352 year: 2015 end-page: 361 article-title: Short‐wavelength enrichment of polychromatic light enhances human melatonin suppression potency publication-title: J Pineal Res – volume: 17 start-page: 4462 year: 2010 end-page: 4481 article-title: Basic mechanisms involved in the anti‐cancer effects of melatonin publication-title: Curr Med Chem – volume: 25 start-page: 9 year: 2006 end-page: 34 article-title: Matrix metalloproteinases and tumor metastasis publication-title: Cancer Metastasis Rev – volume: 126 start-page: 393 year: 2013 end-page: 401 article-title: E‐cadherin‐integrin crosstalk in cancer invasion and metastasis publication-title: J Cell Sci – volume: 52 start-page: 139 year: 2012 end-page: 166 article-title: Melatonin, the circadian multioscillator system and health: the need for detailed analyses of peripheral melatonin signaling publication-title: J Pineal Res – volume: 20 start-page: 303 year: 2016 end-page: 317 article-title: Quinone reductase 2 as a promising target of melatonin therapeutic actions publication-title: Exp Opin Ther Targets – volume: 22 start-page: 201 year: 2001 end-page: 207 article-title: FGF and VEGF function in angiogenesis: signalling pathways, biological responses and therapeutic inhibition publication-title: Trends Pharmacol Sci – volume: 2 start-page: 563 year: 2002 end-page: 572 article-title: Dissemination and growth of cancer cells in metastatic sites publication-title: Nat Rev Cancer – volume: 14 start-page: 1159 year: 2016 end-page: 1169 article-title: Melatonin represses metastasis in Her2‐postive human breast cancer cells by suppressing RSK2 expression publication-title: Mol Cancer Res – volume: 5 start-page: 735 year: 2005 end-page: 743 article-title: Opinion: emerging mechanisms of tumour lymphangiogenesis and lymphatic metastasis publication-title: Nat Rev Cancer – volume: 65 start-page: 430 year: 1997 end-page: 442 article-title: Inhibition of cerebellar nitric oxide synthase and cyclic GMP production by melatonin interaction via complex formation with calmodulin publication-title: J Cell Biochem – volume: 60 start-page: 121 year: 2016 end-page: 131 article-title: Melatonin: the dawning of a treatment for fibrosis? publication-title: J Pineal Res – volume: 14 start-page: 44 year: 2003 end-page: 50 article-title: Emerging role of endothelin‐1 in tumor angiogenesis publication-title: Trends Endocrinol Metab – volume: 144 start-page: 646 year: 2011 end-page: 674 article-title: Hallmarks of cancer: the next generation publication-title: Cell – volume: 51 start-page: 454 year: 2011 end-page: 462 article-title: Melatonin synthesized by T lymphocytes as a ligand of the retinoic acid‐related orphan receptor publication-title: J Pineal Res – volume: 60 start-page: 277 year: 2016 end-page: 290 article-title: Melatonin inhibits MMP‐9 transactivation and renal cell carcinoma metastasis by suppressing Akt‐MAPKs pathway and NF‐kappaB DNA‐binding activity publication-title: J Pineal Res – volume: 120 start-page: 1351 year: 2003 end-page: 1383 article-title: Mechanisms, mechanics and function of epithelial‐mesenchymal transitions in early development publication-title: Mech Dev – volume: 60 start-page: 142 year: 2016 end-page: 154 article-title: Melatonin set out to ER stress signaling thwarts epithelial mesenchymal transition and peritoneal dissemination via calpain‐mediated C/EBPbeta and NFkappaB cleavage publication-title: J Pineal Res – volume: 214 start-page: 145 year: 2012 end-page: 153 article-title: Melatonin inhibits IL1beta‐induced MMP9 expression and activity in human umbilical vein endothelial cells by suppressing NF‐kappaB activation publication-title: J Endocrinol – volume: 48 start-page: 72 year: 2010 end-page: 80 article-title: Synergistic effect of melatonin with chemotherapeutic drugs on human Ewing sarcoma cells: potentiation of the intrinsic apoptotic pathway publication-title: J Pineal Res – volume: 60 start-page: 3 year: 2016 end-page: 15 article-title: Melatonin decreases breast cancer metastasis by modulating Rho‐associated kinase protein‐1 expression publication-title: J Pineal Res – volume: 24 start-page: 306 year: 2004 end-page: 319 article-title: Snail mediates E‐cadherin repression by the recruitment of the Sin3A/histone deacetylase 1 (HDAC1)/HDAC2 complex publication-title: Mol Cell Biol – volume: 18 start-page: 537 year: 2004 end-page: 539 article-title: Evidence of melatonin synthesis by human lymphocytes and its physiological significance: possible role as intracrine, autocrine and/or paracrine substance publication-title: FASEB J – volume: 61 start-page: 127 year: 2016 end-page: 137 article-title: Elevated heart rate and non‐dipping heart rate as possible targets of melatonin: a review publication-title: J Pineal Res – volume: 120 start-page: 1800 year: 2010 end-page: 1803 article-title: Early tumor dissemination, but late metastasis: insights into tumor dormancy publication-title: J Clin Invest – volume: 9 start-page: e101132 year: 2014 article-title: Melatonin inhibits the migration of human lung adenocarcinoma A549 cell lines involving JNK/MAPK pathway publication-title: PLoS ONE – volume: 17 start-page: 347 year: 2011 end-page: 362 article-title: VEGF and angiopoietin signaling in tumor angiogenesis and metastasis publication-title: Trends Mol Med – volume: 34 start-page: 2541 year: 2015 end-page: 2546 article-title: Involvement of nuclear receptor RZR/RORgamma in melatonin‐induced HIF‐1alpha inactivation in SGC‐7901 human gastric cancer cells publication-title: Oncol Rep – volume: 1865 start-page: 176 year: 2016 end-page: 183 article-title: Melatonin and the von Hippel‐Lindau/HIF‐1 oxygen sensing mechanism: a review publication-title: Biochim Biophys Acta – volume: 32 start-page: 2747 year: 2012 end-page: 2753 article-title: Role of melatonin in cancer treatment publication-title: Anticancer Res – volume: 7 start-page: 1267 year: 2001 end-page: 1278 article-title: The two‐handed E box binding zinc finger protein SIP1 downregulates E‐cadherin and induces invasion publication-title: Mol Cell – volume: 26 start-page: 1808 year: 2012 end-page: 1820 article-title: Circadian gating of epithelial‐to‐mesenchymal transition in breast cancer cells via melatonin‐regulation of GSK3beta publication-title: Mol Endocrinol – volume: 109 start-page: 15894 year: 2012 end-page: 15899 article-title: Collaborative interplay between FGF‐2 and VEGF‐C promotes lymphangiogenesis and metastasis publication-title: Proc Natl Acad Sci U S A – volume: 104 start-page: 733 year: 2008 end-page: 744 article-title: NF‐kappaB and epithelial to mesenchymal transition of cancer publication-title: J Cell Biochem – volume: 11 start-page: e0150407 year: 2016 article-title: Effect of Melatonin in epithelial mesenchymal transition markers and invasive properties of breast cancer stem cells of canine and human cell lines publication-title: PLoS ONE – volume: 22 start-page: 45 year: 2001 end-page: 47 article-title: Anti‐angiogenic activity of melatonin in advanced cancer patients publication-title: Neuro Endocrinol Lett – volume: 20 start-page: 2834 year: 2014 end-page: 2842 article-title: VEGF signaling in cancer treatment publication-title: Curr Pharm Des – volume: 58 start-page: 397 year: 2015 end-page: 417 article-title: Anatomical and cellular localization of melatonin MT1 and MT2 receptors in the adult rat brain publication-title: J Pineal Res – volume: 36 start-page: 1607 year: 2000 end-page: 1620 article-title: The E‐cadherin‐catenin complex in tumour metastasis: structure, function and regulation publication-title: Eur J Cancer – volume: 4 start-page: 6 year: 2015 article-title: EMT and tumor metastasis publication-title: Clin Transl Med – volume: 6 start-page: 19 year: 2015 end-page: 28 article-title: Upregulation of miRNA3195 and miRNA374b mediates the anti‐angiogenic properties of melatonin in hypoxic PC‐3 prostate cancer cells publication-title: J Cancer – volume: 55 start-page: 121 year: 2013 end-page: 130 article-title: Melatonin antagonizes hypoxia‐mediated glioblastoma cell migration and invasion via inhibition of HIF‐1alpha publication-title: J Pineal Res – volume: 14 start-page: 306 year: 2014 end-page: 321 article-title: Metastatic stem cells: sources, niches, and vital pathways publication-title: Cell Stem Cell – volume: 14 start-page: 1995 year: 1997 end-page: 1998 article-title: Transcriptional activation of the matrix metalloproteinase‐9 gene in an H‐ras and v‐myc transformed rat embryo cell line publication-title: Oncogene – volume: 3 start-page: 508 year: 2008 end-page: 518 article-title: Wnt signaling mediates self‐organization and axis formation in embryoid bodies publication-title: Cell Stem Cell – volume: 28 start-page: 4772 year: 2008 end-page: 4781 article-title: Polycomb complex 2 is required for E‐cadherin repression by the Snail1 transcription factor publication-title: Mol Cell Biol – volume: 37 start-page: 213 year: 2004 end-page: 214 article-title: Mechanisms of cancer inhibition by melatonin publication-title: J Pineal Res – volume: 351 start-page: 152 year: 2012 end-page: 166 article-title: Melatonin membrane receptors in peripheral tissues: distribution and functions publication-title: Mol Cell Endocrinol – volume: 66 start-page: 9789 year: 2006 end-page: 9793 article-title: Melatonin in cancer management: progress and promise publication-title: Cancer Res – volume: 27 start-page: 119 year: 2005 end-page: 130 article-title: Antioxidative protection by melatonin: multiplicity of mechanisms from radical detoxification to radical avoidance publication-title: Endocrine – volume: 22 start-page: R183 year: 2015 end-page: R204 article-title: Melatonin: an inhibitor of breast cancer publication-title: Endocr Relat Cancer – volume: 58 start-page: 429 year: 2015 end-page: 438 article-title: Melatonin induces apoptosis of colorectal cancer cells through HDAC4 nuclear import mediated by CaMKII inactivation publication-title: J Pineal Res – volume: 9 start-page: 470 year: 2007 end-page: 478 article-title: Oestrogen signalling inhibits invasive phenotype by repressing RelB and its target BCL2 publication-title: Nat Cell Biol – volume: 139 start-page: 871 year: 2009 end-page: 890 article-title: Epithelial‐mesenchymal transitions in development and disease publication-title: Cell – volume: 39 start-page: 212 year: 2007 end-page: 220 article-title: Understanding the biology of angiogenesis: review of the most important molecular mechanisms publication-title: Blood Cells Mol Dis – volume: 29 start-page: 325 year: 2014 end-page: 333 article-title: Melatonin: exceeding expectations. publication-title: Physiology (Bethesda) – volume: 15 start-page: 786 year: 2014 end-page: 801 article-title: Remodelling the extracellular matrix in development and disease publication-title: Nat Rev Mol Cell Biol – volume: 9 start-page: 239 year: 2009 end-page: 252 article-title: Microenvironmental regulation of metastasis publication-title: Nat Rev Cancer – volume: 12 start-page: R107 year: 2010 article-title: Inhibition of breast cancer cell invasion by melatonin is mediated through regulation of the p38 mitogen‐activated protein kinase signaling pathway publication-title: Breast Cancer Res – volume: 59 start-page: 277 year: 2015 end-page: 291 article-title: Inter‐relationships of the chronobiotic, melatonin, with leptin and adiponectin: implications for obesity publication-title: J Pineal Res – volume: 58 start-page: 107 year: 2011 end-page: 116 article-title: On the free radical scavenging activites of melatonin's metabolites, AFMK and AMK publication-title: J Pineal Res – volume: 270 start-page: 7037 year: 1995 end-page: 7040 article-title: The nuclear receptor for melatonin represses 5‐lipoxygenase gene expression in human B lymphocytes publication-title: J Biol Chem – volume: 309 start-page: C627 year: 2015 end-page: C638 article-title: Microenvironment in metastasis: roadblocks and supportive niches publication-title: Am J Physiol Cell Physiol – volume: 43 start-page: 317 year: 2007 end-page: 320 article-title: Melatonin as a naturally occurring co‐substrate of quinone reductase‐2, the putative MT3 melatonin membrane receptor: hypothesis and significance publication-title: J Pineal Res – volume: 18 start-page: 52 year: 2010 end-page: 63 article-title: The tight junction protein, occludin, regulates the directional migration of epithelial cells publication-title: Dev Cell – volume: 28 start-page: 5 year: 2009 end-page: 14 article-title: The cytoskeleton and cancer publication-title: Cancer Metastasis Rev – volume: 269 start-page: 28531 year: 1994 end-page: 28534 article-title: Pineal gland hormone melatonin binds and activates an orphan of the nuclear receptor superfamily publication-title: J Biol Chem – volume: 44 start-page: 107 year: 2008 end-page: 114 article-title: Intracellular signaling pathways involved in cell growth inhibition of human umbilical vein endothelial cells by melatonin publication-title: J Pineal Res – volume: 61 start-page: 3 year: 2016 end-page: 26 article-title: Potential pleiotropic beneficial effects of adjuvant melatoninergic treatment in post traumatic stress disorder publication-title: J Pineal Res – volume: 2 start-page: 737 year: 2000 end-page: 744 article-title: Matrix metalloproteinase‐9 triggers the angiogenic switch during carcinogenesis publication-title: Nat Cell Biol – volume: 26 start-page: 711 year: 2007 end-page: 724 article-title: NF‐kappaB represses E‐cadherin expression and enhances epithelial to mesenchymal transition of mammary epithelial cells: potential involvement of ZEB‐1 and ZEB‐2 publication-title: Oncogene – volume: 44 start-page: 564 year: 2012 end-page: 577 article-title: Obesity and metabolic syndrome: association with chronodisruption, sleep deprivation, and melatonin suppression publication-title: Ann Med – volume: 137 start-page: 1613 year: 2011 end-page: 1618 article-title: Overexpression of osteopontin and integrin alphav in laryngeal and hypopharyngeal carcinomas associated with differentiation and metastasis publication-title: J Cancer Res Clin Oncol – volume: 54 start-page: 264 year: 2013 end-page: 270 article-title: Melatonin suppresses tumor progression by reducing angiogenesis stimulated by HIF‐1 in a mouse tumor model publication-title: J Pineal Res – volume: 37 start-page: 98 year: 2004 end-page: 106 article-title: Melatonin stimulates calmodulin phosphorylation by protein kinase C publication-title: J Pineal Res – volume: 54 start-page: 1299 year: 2002 end-page: 1321 article-title: Melatonin: reducing the toxicity and increasing the efficacy of drugs publication-title: J Pharm Pharmacol – volume: 14 start-page: 151 year: 1993 end-page: 168 article-title: Melatonin, hydroxyl radical‐mediated oxidative damage, and aging: a hypothesis publication-title: J Pineal Res – volume: 15 start-page: 178 year: 2014 end-page: 196 article-title: Molecular mechanisms of epithelial‐mesenchymal transition publication-title: Nat Rev Mol Cell Biol – volume: 11 start-page: 5425 year: 2005 end-page: 5432 article-title: Detection of melanoma cells displaying multiple genomic changes in histopathologically negative sentinel lymph nodes publication-title: Clin Cancer Res – volume: 9 start-page: 25 year: 2005 end-page: 39 article-title: Melatonin as a chronobiotic publication-title: Sleep Med Rev – volume: 58 start-page: 375 year: 2015 end-page: 387 article-title: Melatonin as a treatment for gastrointestinal cancer: a review publication-title: J Pineal Res – volume: 1 start-page: 137 year: 2008 end-page: 149 article-title: Melatonin combats molecular terrorism at the mitochondrial level publication-title: Interdiscip Toxicol – volume: 51 start-page: 17 year: 2011 end-page: 43 article-title: A survey of the molecular details in the human pineal gland in the light of phylogeny, structure, function and chronobiological diseases publication-title: J Pineal Res – volume: 321 start-page: 1785 year: 2008 end-page: 1787 article-title: Cancer. The metastasis cascade publication-title: Science – volume: 171 start-page: 5507 year: 2014 end-page: 5523 article-title: Movers and shakers: cell cytoskeleton in cancer metastasis publication-title: Br J Pharmacol – ident: e_1_2_7_30_1 doi: 10.1111/j.1600-079X.1993.tb00498.x – ident: e_1_2_7_73_1 doi: 10.1111/j.1600-079X.2010.00812.x – ident: e_1_2_7_139_1 doi: 10.1186/bcr2794 – ident: e_1_2_7_46_1 doi: 10.1111/jpi.12330 – ident: e_1_2_7_31_1 doi: 10.1111/jpi.12196 – ident: e_1_2_7_142_1 doi: 10.1111/cpr.12158 – ident: e_1_2_7_78_1 doi: 10.18632/oncotarget.8009 – ident: e_1_2_7_16_1 doi: 10.1152/physiol.00011.2014 – ident: e_1_2_7_79_1 doi: 10.1111/jpi.12365 – ident: e_1_2_7_9_1 doi: 10.1096/fj.03-0694fje – ident: e_1_2_7_133_1 doi: 10.1172/JCI43424 – ident: e_1_2_7_17_1 doi: 10.1111/jpi.12224 – ident: e_1_2_7_12_1 doi: 10.1111/j.1600-079X.2011.00856.x – ident: e_1_2_7_35_1 doi: 10.1385/ENDO:27:2:119 – ident: e_1_2_7_54_1 doi: 10.1111/j.1600-079X.2005.00258.x – ident: e_1_2_7_56_1 doi: 10.1016/j.cell.2011.02.013 – ident: e_1_2_7_64_1 doi: 10.1016/S0092-8674(02)00971-6 – ident: e_1_2_7_7_1 doi: 10.1038/nrc2618 – ident: e_1_2_7_74_1 doi: 10.1111/jpi.12034 – ident: e_1_2_7_32_1 doi: 10.1111/jpi.12267 – ident: e_1_2_7_13_1 doi: 10.1111/jpi.12221 – ident: e_1_2_7_68_1 doi: 10.1038/nrc2621 – ident: e_1_2_7_21_1 doi: 10.1016/S0021-9258(19)61934-4 – ident: e_1_2_7_62_1 doi: 10.1371/journal.pone.0101132 – ident: e_1_2_7_69_1 doi: 10.1038/nrm3904 – ident: e_1_2_7_5_1 doi: 10.1158/0008-5472.CAN-06-2407 – ident: e_1_2_7_109_1 doi: 10.1210/me.2012-1071 – ident: e_1_2_7_111_1 doi: 10.1155/2012/743193 – ident: e_1_2_7_29_1 doi: 10.1517/14728222.2016.1091882 – ident: e_1_2_7_51_1 doi: 10.18632/oncotarget.8776 – ident: e_1_2_7_122_1 doi: 10.1016/S1043-2760(02)00010-3 – ident: e_1_2_7_8_1 doi: 10.1021/ja01543a060 – ident: e_1_2_7_91_1 doi: 10.1038/nrm3758 – ident: e_1_2_7_3_1 doi: 10.1016/j.stem.2014.02.002 – ident: e_1_2_7_103_1 doi: 10.1038/ncb1559 – ident: e_1_2_7_49_1 doi: 10.1517/14728222.2013.834890 – ident: e_1_2_7_124_1 doi: 10.1074/jbc.M202421200 – ident: e_1_2_7_43_1 doi: 10.1111/jpi.12240 – ident: e_1_2_7_136_1 doi: 10.2174/092986710791233689 – ident: e_1_2_7_81_1 doi: 10.1111/bph.12704 – ident: e_1_2_7_120_1 doi: 10.3892/or.2015.4238 – ident: e_1_2_7_71_1 doi: 10.1016/S0165-6147(00)01676-X – ident: e_1_2_7_20_1 doi: 10.1111/j.1600-079X.2011.00909.x – ident: e_1_2_7_11_1 doi: 10.1007/s00018-014-1579-2 – ident: e_1_2_7_97_1 doi: 10.1038/sj.onc.1208429 – ident: e_1_2_7_65_1 doi: 10.1186/s12967-015-0454-8 – ident: e_1_2_7_4_1 doi: 10.1038/nrc865 – ident: e_1_2_7_67_1 doi: 10.1007/s00432-011-1024-y – volume: 22 start-page: 45 year: 2001 ident: e_1_2_7_116_1 article-title: Anti‐angiogenic activity of melatonin in advanced cancer patients publication-title: Neuro Endocrinol Lett – volume: 10 start-page: 353 year: 1999 ident: e_1_2_7_107_1 article-title: Transcriptional up‐regulation of matrix metalloproteinase‐9 expression during spontaneous epithelial to neuroblast phenotype conversion by SK‐N‐SH neuroblastoma cells, involved in enhanced invasivity, depends upon GT‐box and nuclear factor kappaB elements publication-title: Cell Growth Differ – ident: e_1_2_7_47_1 doi: 10.1111/jpi.12302 – ident: e_1_2_7_10_1 doi: 10.1111/j.1600-079X.2011.00931.x – volume: 58 start-page: 4383 year: 1998 ident: e_1_2_7_59_1 article-title: Influence of melatonin on invasive and metastatic properties of MCF‐7 human breast cancer cells publication-title: Cancer Res – ident: e_1_2_7_34_1 doi: 10.2478/v10102-010-0030-2 – ident: e_1_2_7_84_1 doi: 10.1007/s00005-015-0382-6 – ident: e_1_2_7_85_1 doi: 10.1111/jpi.12270 – ident: e_1_2_7_40_1 doi: 10.1385/ENDO:27:2:201 – ident: e_1_2_7_113_1 doi: 10.1016/j.bcmd.2007.04.001 – ident: e_1_2_7_45_1 doi: 10.1111/jpi.12348 – ident: e_1_2_7_25_1 doi: 10.1111/j.1600-079X.2004.00141.x – ident: e_1_2_7_37_1 doi: 10.1111/j.1600-079X.2011.00934.x – ident: e_1_2_7_72_1 doi: 10.1038/nrc1693 – ident: e_1_2_7_41_1 doi: 10.1111/jpi.12227 – ident: e_1_2_7_42_1 doi: 10.1530/ERC-15-0030 – ident: e_1_2_7_50_1 doi: 10.1111/jpi.12226 – ident: e_1_2_7_19_1 doi: 10.1016/j.pneurobio.2010.12.004 – ident: e_1_2_7_18_1 doi: 10.1016/j.smrv.2004.05.002 – ident: e_1_2_7_75_1 doi: 10.1038/35036374 – ident: e_1_2_7_105_1 doi: 10.1038/sj.onc.1201012 – ident: e_1_2_7_140_1 doi: 10.1016/j.canlet.2009.06.016 – ident: e_1_2_7_89_1 doi: 10.1080/15384101.2015.1063296 – ident: e_1_2_7_110_1 doi: 10.1158/1541-7786.MCR-16-0158 – ident: e_1_2_7_80_1 doi: 10.1007/s10555-008-9166-3 – ident: e_1_2_7_6_1 doi: 10.1038/nrc3125 – ident: e_1_2_7_119_1 doi: 10.7150/jca.9591 – ident: e_1_2_7_127_1 doi: 10.1111/j.1600-079X.2007.00496.x – ident: e_1_2_7_53_1 doi: 10.2174/092986710794183015 – ident: e_1_2_7_123_1 doi: 10.1016/S0002-9440(10)64807-9 – ident: e_1_2_7_57_1 doi: 10.1158/0008-5472.CAN-07-2938 – ident: e_1_2_7_121_1 doi: 10.1016/j.bbcan.2016.02.004 – ident: e_1_2_7_94_1 doi: 10.1126/science.1234850 – ident: e_1_2_7_60_1 doi: 10.1111/jpi.12295 – ident: e_1_2_7_96_1 doi: 10.1016/S1097-2765(01)00260-X – volume: 268 start-page: 2180 year: 1993 ident: e_1_2_7_101_1 article-title: Activation of the human vimentin gene by the Tax human T‐cell leukemia virus. I. Mechanisms of regulation by the NF‐kappa B transcription factor publication-title: J Biol Chem doi: 10.1016/S0021-9258(18)53979-X – ident: e_1_2_7_22_1 doi: 10.1074/jbc.270.13.7037 – ident: e_1_2_7_77_1 doi: 10.1111/jpi.12308 – ident: e_1_2_7_63_1 doi: 10.1016/j.devcel.2009.12.008 – ident: e_1_2_7_141_1 doi: 10.1111/j.1600-079X.2009.00727.x – ident: e_1_2_7_83_1 doi: 10.1111/j.1600-079X.2008.00600.x – ident: e_1_2_7_106_1 doi: 10.1002/(SICI)1097-0215(20000415)86:2<188::AID-IJC7>3.0.CO;2-W – ident: e_1_2_7_98_1 doi: 10.1128/MCB.24.1.306-319.2004 – ident: e_1_2_7_135_1 doi: 10.18632/genesandcancer.107 – ident: e_1_2_7_36_1 doi: 10.1111/jpi.12026 – ident: e_1_2_7_58_1 doi: 10.1016/S0959-8049(00)00158-1 – ident: e_1_2_7_61_1 doi: 10.1016/j.bbamem.2008.11.005 – ident: e_1_2_7_28_1 doi: 10.1111/j.1600-079X.2007.00513.x – ident: e_1_2_7_129_1 doi: 10.1038/nm1469 – ident: e_1_2_7_114_1 doi: 10.1016/j.molmed.2011.01.015 – ident: e_1_2_7_115_1 doi: 10.2174/13816128113199990590 – ident: e_1_2_7_102_1 doi: 10.1038/sj.onc.1209808 – ident: e_1_2_7_126_1 doi: 10.1016/j.mvr.2013.02.008 – ident: e_1_2_7_134_1 doi: 10.1016/S0065-230X(09)02003-X – ident: e_1_2_7_76_1 doi: 10.1007/s10555-006-7886-9 – ident: e_1_2_7_38_1 doi: 10.3390/ijms151223448 – ident: e_1_2_7_104_1 doi: 10.1371/journal.pone.0150407 – ident: e_1_2_7_24_1 doi: 10.1002/(SICI)1097-4644(19970601)65:3<430::AID-JCB12>3.0.CO;2-J – ident: e_1_2_7_26_1 doi: 10.1007/BF01923944 – ident: e_1_2_7_99_1 doi: 10.1038/nrm757 – ident: e_1_2_7_55_1 doi: 10.1016/S0304-419X(01)00038-5 – ident: e_1_2_7_118_1 doi: 10.1111/jpi.12052 – volume: 32 start-page: 2747 year: 2012 ident: e_1_2_7_48_1 article-title: Role of melatonin in cancer treatment publication-title: Anticancer Res – ident: e_1_2_7_87_1 doi: 10.1016/j.mod.2003.06.005 – ident: e_1_2_7_27_1 doi: 10.1074/jbc.M403140200 – ident: e_1_2_7_33_1 doi: 10.1111/jpi.12360 – ident: e_1_2_7_137_1 doi: 10.1211/002235702760345374 – ident: e_1_2_7_70_1 doi: 10.1073/pnas.1208324109 – ident: e_1_2_7_92_1 doi: 10.1172/JCI38019 – ident: e_1_2_7_93_1 doi: 10.1016/j.cell.2009.11.007 – ident: e_1_2_7_117_1 doi: 10.1111/j.1600-079X.2012.01030.x – ident: e_1_2_7_39_1 doi: 10.3109/07853890.2011.586365 – ident: e_1_2_7_112_1 doi: 10.2174/138161209788453275 – ident: e_1_2_7_131_1 doi: 10.1126/science.1164853 – ident: e_1_2_7_52_1 doi: 10.1111/j.1600-079X.2004.00165.x – ident: e_1_2_7_82_1 doi: 10.1242/jcs.100115 – ident: e_1_2_7_100_1 doi: 10.1002/jcb.21695 – ident: e_1_2_7_132_1 doi: 10.1158/1078-0432.CCR-04-1995 – ident: e_1_2_7_125_1 doi: 10.1111/jpi.12131 – ident: e_1_2_7_130_1 doi: 10.1152/ajpcell.00145.2015 – ident: e_1_2_7_66_1 doi: 10.1016/j.ajpath.2011.07.011 – ident: e_1_2_7_95_1 doi: 10.1128/MCB.00323-08 – ident: e_1_2_7_138_1 doi: 10.1158/0008-5472.CAN-06-1776 – ident: e_1_2_7_2_1 doi: 10.1002/path.2727 – ident: e_1_2_7_108_1 doi: 10.1016/j.stem.2008.09.013 – ident: e_1_2_7_86_1 doi: 10.2174/1871520614666140812110246 – ident: e_1_2_7_90_1 doi: 10.1242/jcs.02552 – ident: e_1_2_7_44_1 doi: 10.1111/jpi.12257 – ident: e_1_2_7_128_1 doi: 10.1530/JOE-12-0147 – ident: e_1_2_7_23_1 doi: 10.1016/S0165-5728(98)00179-9 – ident: e_1_2_7_15_1 doi: 10.1016/j.mce.2012.01.004 – ident: e_1_2_7_14_1 doi: 10.1016/S0079-6123(08)81008-4 – ident: e_1_2_7_88_1 doi: 10.1186/s40169-015-0048-3 |
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| Snippet | Melatonin is a naturally occurring molecule secreted by the pineal gland and known as a gatekeeper of circadian clocks. Mounting evidence indicates that... |
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| SubjectTerms | angiogenesis Animals epithelial–mesenchymal transition Humans matrix metalloproteinase melatonin Melatonin - metabolism metastasis Neoplasm Metastasis - pathology |
| Title | Cancer metastasis: Mechanisms of inhibition by melatonin |
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