Nebulized Terbutaline and Ipratropium Bromide Versus Terbutaline Alone in Acute Exacerbation of Chronic Obstructive Pulmonary Disease Requiring Noninvasive Ventilation: A Randomized Double‐blind Controlled Trial

• Published in: Academic emergency medicine Vol. 26; no. 4; pp. 434 - 442
• Main Authors: Beltaief, Kaouthar, Msolli, Mohamed Amine, Zorgati, Asma, Sekma, Adel, Fakhfakh, Marwen, Marzouk, Maryem Ben, Boubaker, Hamdi, Grissa, Mohamed Habib, Methamem, Mehdi, Boukef, Riadh, Belguith, Asma, Bouida, Wahid, Nouira, Semir, Heard, Kennon J.
• Format: Journal Article
• Language: English
• Published: United States Wiley Subscription Services, Inc 01.04.2019
• Subjects: Acute Disease - therapy; Administration, Inhalation; Bronchodilator Agents - administration & dosage; Chronic obstructive pulmonary disease; Clinical trials; Double-Blind Method; Double-blind studies; Drug therapy; Drug Therapy, Combination; Dyspnea; Emergency medical care; Emergency Service, Hospital; Evidence-based medicine; Female; Hospitalization - statistics & numerical data; Humans; Ipratropium - administration & dosage; Male; Middle Aged; Patient admissions; Pulmonary Disease, Chronic Obstructive - drug therapy; Respiratory therapy; Terbutaline - administration & dosage; Ventilators

Background Short‐acting β2‐agonists are the mainstay of treatment of patients with acute exacerbation of chronic obstructive pulmonary disease (AECOPD) in the emergency department (ED). It is still unclear whether the addition of short‐acting anticholinergics is clinically more effective care compar...