Desensitization of human renal D1 dopamine receptors by G protein-coupled receptor kinase 4

• Published in: Kidney international Vol. 62; no. 3; pp. 790 - 798
• Main Authors: Watanabe, Hidetsuna, Xu, Jing, Bengra, Chikh, Jose, Pedro A., Felder, Robin A.
• Format: Journal Article
• Language: English
• Published: New York, NY Elsevier Inc 01.09.2002; Nature Publishing; Elsevier Limited
• Subjects: Anticoagulants - pharmacology; beta-Adrenergic Receptor Kinases; Biological and medical sciences; Cells, Cultured; Colforsin - pharmacology; Cyclic AMP - metabolism; Cyclic AMP-Dependent Protein Kinases - genetics; Cyclic AMP-Dependent Protein Kinases - metabolism; Dopamine Agonists - pharmacology; Enzyme Activation - drug effects; Fenoldopam - pharmacology; Fundamental and applied biological sciences. Psychology; G-Protein-Coupled Receptor Kinase 4; GRK4; Heparin - pharmacology; Humans; hypertension; Kidney Tubules, Proximal - cytology; Kidney Tubules, Proximal - metabolism; Oligonucleotides, Antisense - pharmacology; Protein-Serine-Threonine Kinases - antagonists & inhibitors; Protein-Serine-Threonine Kinases - genetics; Protein-Serine-Threonine Kinases - metabolism; Receptors, Dopamine D1 - metabolism; renal proximal tubules; sodium transport; Vertebrates: urinary system; water and electron transport; sodium transport; GRK4; hypertension; water and electron transport; renal proximal tubules; Water; Human; Hypertension; Dopamine; Desensitization; Enzyme; Transferases; Biological transport; Cardiovascular disease; Renal tubule; Electrolyte; Sodium; Kinase; Nephron; Receptor protein; Biological receptor

Desensitization of human renal D1 dopamine receptors by G protein-coupled receptor kinase 4. The D1 dopamine receptor, expressed in several nephron segments, participates in the regulation of water and electrolyte transport. Because the renal D1 receptor is desensitized in genetic hypertension, we s...