OBF1 and Oct factors control the germinal center transcriptional program

• Published in: Blood Vol. 137; no. 21; pp. 2920 - 2934
• Main Authors: Song, Shuang, Cao, Chun, Choukrallah, Mohamed-Amin, Tang, Fengyuan, Christofori, Gerhard, Kohler, Hubertus, Wu, Fabian, Fodor, Barna D., Frederiksen, Mathias, Willis, Simon N., Jackson, Jacob T., Nutt, Stephen L., Dirnhofer, Stefan, Stadler, Michael B., Matthias, Patrick
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 27.05.2021

OBF1 is a specific coactivator of the POU family transcription factors OCT1 and OCT2. OBF1 and OCT2 are B cell–specific and indispensable for germinal center (GC) formation, but their mechanism of action is unclear. Here, we show by chromatin immunoprecipitation-sequencing that OBF1 extensively colo...