New model for adenine-induced chronic renal failure in mice, and the effect of gum acacia treatment thereon: Comparison with rats

• Published in: Journal of pharmacological and toxicological methods Vol. 68; no. 3; pp. 384 - 393
• Main Authors: Ali, Badreldin H., Al-Salam, Suhail, Al Za'abi, Mohammed, Waly, Mostafa I., Ramkumar, Aishwarya, Beegam, Sumyia, Al-Lawati, Intisar, Adham, Sirin A., Nemmar, Abderrahim
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.11.2013
• Subjects: Acacia; Adenine; Adenine - administration & dosage; Adenine - toxicity; Animal model; Animals; Chronic renal failure; Creatinine - blood; Disease Models, Animal; Dose-Response Relationship, Drug; Glutathione - metabolism; Gum Arabic - pharmacology; Kidney Failure, Chronic - drug therapy; Kidney Failure, Chronic - physiopathology; Male; Mice; Mice, Inbred C57BL; Rats; Rats, Wistar; Severity of Illness Index; Species Specificity; Superoxide Dismutase - metabolism; Urea - metabolism; Adenine; Rats; Animal model; Mice; Chronic renal failure

This study aimed at comparing the effects of feeding mice and rats with adenine to induce a state of chronic renal failure (CRF), and to assess the effect of treatment with gum acacia (GA) thereon. We compared the outcome, in mice, of feeding adenine at three different doses (0.75%, 0.3%, and 0.2%,...