Opposite Expression Patterns of Spry3 and p75NTR in Cerebellar Vermis Suggest a Male-Specific Mechanism of Autism Pathogenesis

• Published in: Frontiers in psychiatry Vol. 10; p. 416
• Main Authors: Ning, Zhenfei, Williams, John M, Kumari, Romika, Baranov, Pavel V, Moore, Tom
• Format: Journal Article
• Language: English
• Published: Switzerland Frontiers Media S.A 18.06.2019
• Subjects: autism; cerebellum; p75NTR; pseudoautosomal region; Psychiatry; SPRY3; TMLHE; p75NTR; TMLHE; SPRY3; carnitine; pseudoautosomal region; autism; cerebellum

Autism is a genetically complex neurobehavioral disorder with a population prevalence of more than 1%. Cerebellar abnormalities, including Purkinje cell deficits in the vermis, are consistently reported, and rodent models of cerebellar dysfunction exhibit features analogous to human autism. We previ...