The role of the cAMP-PKA system in the short-term regulation of striatal [ 14C]-2-deoxyglucose uptake in freely moving rats

• Published in: Brain research Vol. 921; no. 1; pp. 260 - 263
• Main Authors: Hosoi, Rie, Momosaki, Sotaro, Ibii, Nobuhiro, Abe, Kohji, Itoh, Takashi, Inoue, Osamu
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 07.12.2001
• Subjects: 2-Deoxyglucose; Animals; Brain; Carbon Radioisotopes; Cerebrovascular Circulation - drug effects; Cerebrovascular Circulation - physiology; Cyclic AMP - analogs & derivatives; Cyclic AMP - metabolism; Cyclic AMP - pharmacology; Cyclic AMP-Dependent Protein Kinases - antagonists & inhibitors; Cyclic AMP-Dependent Protein Kinases - metabolism; db-cAMP; Deoxyglucose; Energy Metabolism - drug effects; Energy Metabolism - physiology; Enzyme Inhibitors - pharmacology; Glucose - metabolism; Male; Movement - drug effects; Movement - physiology; Neostriatum - drug effects; Neostriatum - enzymology; Neurons - drug effects; Neurons - metabolism; Phosphorylation - drug effects; Protein kinase A; Rat; Rats; Rats, Sprague-Dawley; Rp-cAMPS; Thionucleotides - pharmacology; Protein kinase A; 2-Deoxyglucose; Other systems of the CNS; Brain; db-cAMP; Rat; Rp-cAMPS

The cyclic adenosine monophosphate (cAMP)-protein kinase (PK) A system has been shown to have stimulatory effects on glucose utilization in various tissues in vitro. However, little is known about the influence of cAMP on glucose utilization in vivo. In the present study, we examined how cAMP-relate...