Ketone Body Exposure of Cardiomyocytes Impairs Insulin Sensitivity and Contractile Function through Vacuolar-Type H+-ATPase Disassembly—Rescue by Specific Amino Acid Supplementation

• Published in: International journal of molecular sciences Vol. 23; no. 21; p. 12909
• Main Authors: Wang, Shujin, Neumann, Dietbert, Westenbrink, B. Daan, Schianchi, Francesco, Wong, Li-Yen, Sun, Aomin, Strzelecka, Agnieszka, Glatz, Jan F. C., Luiken, Joost J. F. P., Nabben, Miranda
• Format: Journal Article
• Language: English
• Published: Basel MDPI AG 01.11.2022; MDPI
• Subjects: Acidification; Cardiomyocytes; Diabetes; Glucose; Heart failure; Insulin resistance; Lipids; Metabolism; Physiology

The heart is metabolically flexible. Under physiological conditions, it mainly uses lipids and glucose as energy substrates. In uncontrolled diabetes, the heart switches towards predominant lipid utilization, which over time is detrimental to cardiac function. Additionally, diabetes is accompanied b...