miR-29a-3p/THBS2 Axis Regulates PAH-Induced Cardiac Fibrosis

• Published in: International journal of molecular sciences Vol. 22; no. 19; p. 10574
• Main Authors: Hsu, Chih-Hsin, Liu, I-Fan, Kuo, Hsuan-Fu, Li, Chia-Yang, Lian, Wei-Shiung, Chang, Chia-Yuan, Chen, Yung-Hsiang, Liu, Wei-Lun, Lu, Chi-Yu, Liu, Yu-Ru, Lin, Tzu-Chieh, Lee, Tsung-Ying, Huang, Chi-Yuan, Hsieh, Chong-Chao, Liu, Po-Len
• Format: Journal Article
• Language: English
• Published: Basel MDPI AG 01.10.2021; MDPI
• Subjects: Apoptosis; Autophagy; Cardiac catheterization; Cardiomyocytes; Cardiomyopathy; Cell culture; Collagen; Fibroblasts; Flow velocity; Heart failure; Homeostasis; Intubation; Laboratory animals; Medical prognosis; Proteins; Pulmonary arteries; Stem cells; Veins & arteries; United States > US; Taiwan

Pulmonary artery hypertension (PAH) pathology involves extracellular matrix (ECM) remodeling in cardiac tissues, thus promoting cardiac fibrosis progression. miR-29a-3p reportedly inhibits lung progression and liver fibrosis by regulating ECM protein expression; however, its role in PAH-induced fibr...