Upregulation of ENAH by a PI3K/AKT/β-catenin cascade promotes oral cancer cell migration and growth via an ITGB5/Src axis

• Published in: Cellular & molecular biology letters Vol. 29; no. 1; pp. 136 - 25
• Main Authors: Chan, Xiu-Ya, Chang, Kai-Ping, Yang, Chia-Yu, Liu, Chiao-Rou, Hung, Chu-Mi, Huang, Chun-Chueh, Liu, Hao-Ping, Wu, Chih-Ching
• Format: Journal Article
• Language: English
• Published: England BioMed Central 07.11.2024; BMC
• Subjects: 1-Phosphatidylinositol 3-kinase; AKT protein; Animal models; Animals; beta Catenin - genetics; beta Catenin - metabolism; Cell activation; Cell culture; Cell Line, Tumor; Cell migration; Cell Movement - genetics; Cell proliferation; Cell Proliferation - genetics; Cell survival; Clinical trials; Ectopic expression; Epidermal growth factor; Female; Gene Expression Regulation, Neoplastic; GSK3β/β-catenin signaling; Head & neck cancer; Humans; Immunohistochemistry; Integrin beta Chains - genetics; Integrin beta Chains - metabolism; Integrin β5 (ITGB5); Male; Mass spectrometry; Medical prognosis; Medical research; Metastasis; Mice; Mice, Nude; Mouth Neoplasms - genetics; Mouth Neoplasms - metabolism; Mouth Neoplasms - pathology; Oral cancer; Oral carcinoma; Oral cavity; Oral cavity squamous cell carcinoma (OSCC); Patient-derived xenograft (PDX); Patients; Peptides; Phosphatidylinositol 3-Kinases - genetics; Phosphatidylinositol 3-Kinases - metabolism; Protein-enabled homolog (ENAH); Proteins; Proteomes; Proteomics; Proto-Oncogene Proteins c-akt - genetics; Proto-Oncogene Proteins c-akt - metabolism; Ratios; Scientific imaging; Signal Transduction; Software; Squamous cell carcinoma; Src protein; src-Family Kinases - genetics; src-Family Kinases - metabolism; Transcriptomes; Tumors; Up-regulation; Up-Regulation - genetics; β-Catenin; United States > US; Taiwan; Integrin β5 (ITGB5); Oral cavity squamous cell carcinoma (OSCC); Patient-derived xenograft (PDX); GSK3β/β-catenin signaling; Protein-enabled homolog (ENAH); Proteomics

Oral cancer accounts for 2% of cancer-related deaths globally, with over 90% of cases being oral cavity squamous cell carcinomas (OSCCs). Approximately 50% of patients with OSCC succumb to the disease within 5 years, primarily due to the advanced stage at which it is typically diagnosed. This unders...