Upregulation of ENAH by a PI3K/AKT/β-catenin cascade promotes oral cancer cell migration and growth via an ITGB5/Src axis - Chan, Xiu-Ya; Chang, Kai-Ping; Yang, Chia-Yu; Liu, Chiao-Rou; Hung, Chu-Mi; Huang, Chun-Chueh; Liu, Hao-Ping; Wu, Chih-Ching (Cellular & molecular biology letters, 2024)
Keywords: 1-Phosphatidylinositol 3-kinase; AKT protein; Animal models; Animals; beta Catenin - genetics; beta Catenin - metabolism; Cell activation; Cell culture; Cell Line, Tumor; Cell migration; Cell Movement - genetics; Cell proliferation; Cell Proliferation - genetics; Cell survival; Clinical trials; Ectopic expression; Epidermal growth factor; Female; Gene Expression Regulation, Neoplastic; GSK3β/β-catenin signaling; Head & neck cancer; Humans; Immunohistochemistry; Integrin beta Chains - genetics; Integrin beta Chains - metabolism; Integrin β5 (ITGB5); Male; Mass spectrometry; Medical prognosis; Medical research; Metastasis; Mice; Mice, Nude; Mouth Neoplasms - genetics; Mouth Neoplasms - metabolism; Mouth Neoplasms - pathology; Oral cancer; Oral carcinoma; Oral cavity; Oral cavity squamous cell carcinoma (OSCC); Patient-derived xenograft (PDX); Patients; Peptides; Phosphatidylinositol 3-Kinases - genetics; Phosphatidylinositol 3-Kinases - metabolism; Protein-enabled homolog (ENAH); Proteins; Proteomes; Proteomics; Proto-Oncogene Proteins c-akt - genetics; Proto-Oncogene Proteins c-akt - metabolism; Ratios; Scientific imaging; Signal Transduction; Software; Squamous cell carcinoma; Src protein; src-Family Kinases - genetics; src-Family Kinases - metabolism; Transcriptomes; Tumors; Up-regulation; Up-Regulation - genetics; β-Catenin; United States--US; Taiwan; Integrin β5 (ITGB5); Oral cavity squamous cell carcinoma (OSCC); Patient-derived xenograft (PDX); GSK3β/β-catenin signaling; Protein-enabled homolog (ENAH); Proteomics