Metabolomic identification of α-ketoglutaric acid elevation in pediatric chronic graft-versus-host disease

• Published in: Blood Vol. 139; no. 2; pp. 287 - 299
• Main Authors: Subburaj, Divya, Ng, Bernard, Kariminia, Amina, Abdossamadi, Sayeh, Lauener, Madeline, Nemecek, Eneida R., Rozmus, Jacob, Kharbanda, Sandhya, Kitko, Carrie L., Lewis, Victor A., Schechter-Finklestein, Tal, Jacobsohn, David A., Harris, Andrew C., Pulsipher, Michael A., Bittencourt, Henrique, Choi, Sung Won, Caywood, Emi H., Kasow, Kimberly A., Bhatia, Monica, Oshrine, Benjamin R., Coulter, Donald, Chewning, Joseph H., Joyce, Michael, Pawlowska, Anna B., Megason, Gail C., Lawitschka, Anita, Ostroumov, Elena, Klein Geltink, Ramon, Cuvelier, Geoffrey D.E., Schultz, Kirk R.
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 13.01.2022
• Subjects: Adolescent; Biomarkers - blood; Biomarkers - metabolism; Child; Child, Preschool; Chronic Disease; Female; Graft vs Host Disease - blood; Graft vs Host Disease - metabolism; Hematopoietic Stem Cell Transplantation - adverse effects; Humans; Infant; Ketoglutaric Acids - blood; Ketoglutaric Acids - metabolism; Male; Metabolome; Risk Assessment

Chronic graft-versus-host disease (cGVHD) is the most common cause for non-relapse mortality postallogeneic hematopoietic stem cell transplant (HSCT). However, there are no well-defined biomarkers for cGVHD or late acute GVHD (aGVHD). This study is a longitudinal evaluation of metabolomic patterns o...