A study to investigate changes in the levels of biomarkers of exposure to selected cigarette smoke constituents in Japanese adult male smokers who switched to a non-combustion inhaler type of tobacco product

• Published in: Regulatory toxicology and pharmacology Vol. 71; no. 3; pp. 498 - 506
• Main Authors: Miura, Naoki, Yuki, Dai, Minami, Naoki, Kakehi, Aoi, Futamura, Yasuyuki
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier Inc 01.04.2015
• Subjects: Adult; Biomarkers; Biomarkers - blood; Biomarkers - urine; Blood Chemical Analysis; Cigarette; Clinical study; Exposure; Humans; Japan; Male; Middle Aged; Mutagenicity Tests; Mutagens - adverse effects; Risk Assessment; Smoke - adverse effects; Smokeless tobacco; Smoking; Smoking - adverse effects; Smoking - blood; Smoking - urine; Time Factors; Tobacco Products - adverse effects; Tobacco, Smokeless - adverse effects; Urinalysis; Young Adult; Japan; Cigarette; Biomarkers; Exposure; Smokeless tobacco; Smoking; Clinical study

•A non-combustion inhaler type of tobacco product (NCIT) was investigated.•Clinical study was conducted with 60 Japanese male smokers and 20 non-smokers.•Change in levels in 14 biomarker of exposure (BOE) were monitored for 4weeks.•Switching from cigarette to NCIT showed significant reduction in all...