Interaction of some steroid drugs with β-cyclodextrin polymer

The interaction of 15 steroidal drugs with a water-soluble β-cyclodextrin polymer was studied by reversed-phase thin-layer chromatography in the absence and in the presence of 0.1 M sodium chloride. The relative strength of interaction was calculated and the relationship between the hydrophobicity p...

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Bibliographic Details
Published inJournal of Chromatography A Vol. 845; no. 1; pp. 447 - 453
Main Authors FORGACS, E, CSERHATI, T
Format Journal Article Conference Proceeding
LanguageEnglish
Published Amsterdam Elsevier B.V 11.06.1999
Elsevier
Subjects
Alicyclic compounds, terpenoids, prostaglandins, steroids
beta-Cyclodextrins
Biological and medical sciences
Chemical Phenomena
Chemistry
Chemistry, Physical
Chromatography, High Pressure Liquid
Cyclodextrins
Cyclodextrins - chemistry
Drugs, steroidal
Exact sciences and technology
General pharmacology
Medical sciences
Molecular Structure
Organic chemistry
Pharmaceutical technology. Pharmaceutical industry
Pharmacology. Drug treatments
Polymers - chemistry
Preparations and properties
Sodium Chloride - pharmacology
Solubility
Steroids
Steroids - chemistry
Water
Complexation
Cyclodextrins
Pharmaceutical analysis
Drugs, steroidal
Principal component analysis
Steroids
Drug
Steroid
Phase composition
Lipophily
Mobile phase
Thin layer chromatography
Reversed phase chromatography
Cyclodextrin
Salt effect
Investigation method
Medium effect
Oside polymer
Inclusion compound
Polysaccharide
Chemometrics
Sodium Chlorides
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Summary:The interaction of 15 steroidal drugs with a water-soluble β-cyclodextrin polymer was studied by reversed-phase thin-layer chromatography in the absence and in the presence of 0.1 M sodium chloride. The relative strength of interaction was calculated and the relationship between the hydrophobicity parameters of the drugs and the strength of the drug–β-cyclodextrin polymer was elucidated by principal component analysis. Drugs readily formed inclusion complexes with the cyclodextrin derivatives; the strength of the interaction was higher in the presence of sodium chloride. It was assumed that the formation of inclusion complexes may influence the behaviour of the drugs resulting in modified biological efficacy.
ISSN:0021-9673
DOI:10.1016/S0021-9673(99)00005-9