Excluding infection through procalcitonin testing improves outcomes of congestive heart failure patients presenting with acute respiratory symptoms: Results from the randomized ProHOSP trial

• Published in: International journal of cardiology Vol. 175; no. 3; pp. 464 - 472
• Main Authors: Schuetz, Philipp, Kutz, Alexander, Grolimund, Eva, Haubitz, Sebastian, Demann, Désirée, Vögeli, Alaadin, Hitz, Fabienne, Christ-Crain, Mirjam, Thomann, Robert, Falconnier, Claudine, Hoess, Claus, Henzen, Christoph, Marlowe, Robert J, Zimmerli, Werner, Mueller, Beat
• Format: Journal Article
• Language: English
• Published: Shannon Elsevier 20.08.2014
• Subjects: Aged; Aged, 80 and over; Anti-Bacterial Agents - therapeutic use; Antibacterial agents; Antibiotics. Antiinfectious agents. Antiparasitic agents; Biological and medical sciences; Biomarkers - blood; Calcitonin - blood; Calcitonin Gene-Related Peptide; Cardiology. Vascular system; Cardiovascular; Female; Heart; Heart Failure - blood; Heart Failure - drug therapy; Heart Failure - epidemiology; Heart failure, cardiogenic pulmonary edema, cardiac enlargement; Humans; Male; Medical sciences; Middle Aged; Pharmacology. Drug treatments; Prospective Studies; Protein Precursors - blood; Respiratory Tract Infections - blood; Respiratory Tract Infections - drug therapy; Respiratory Tract Infections - epidemiology; Switzerland - epidemiology; Treatment Outcome; CHF; PCT; OR; CI; Antibiotic therapy; procalcitonin; emergency room; odds ratio; SD; Biomarkers in Acute Heart Failure trial; LRTI; congestive heart failure; lower respiratory infection; BACH; confidence interval; ICU; intensive care unit; Differential diagnosis; acute heart failure; Antibiotic stewardship; AHF; ED; standard deviation; Prognosis; Procalcitonin; Cardiovascular disease; Respiratory system; Result; Respiratory tract; Improvement; Heart disease; Clinical trial; Evolution; Cardiology; Human; Heart failure; Acute; Patient; Medical screening; Differential diagnostic; Infection; Symptomatology; Antibiotic; Treatment; Acute heart failure; Antibacterial agent; Inaugural sign

Abstract Background/objectives We sought to determine whether exclusion of infection and antibiotic stewardship with the infection biomarker procalcitonin improves outcomes in congestive heart failure (CHF) patients presenting to emergency departments with respiratory symptoms and suspicion of respi...