Alternative splicing variant of NRP/B promotes tumorigenesis of gastric cancer

• Published in: BMB reports Vol. 55; no. 7; pp. 348 - 353
• Main Authors: Kim, Aram, Mok, Bo Ram, Hahn, Soojung, Yoo, Jongman, Kim, Dong Hyun, Kim, Tae-Aug
• Format: Journal Article
• Language: English
• Published: Korea (South) Korean Society for Biochemistry and Molecular Biology 31.07.2022; 생화학분자생물학회
• Subjects: Alternative Splicing - genetics; Carcinogenesis - genetics; Cell Line, Tumor; Gastrointestinal Neoplasms; Gene Expression Regulation, Neoplastic; Humans; RNA, Messenger; Stomach Neoplasms - genetics; 화학

Gastrointestinal cancer is associated with a high mortality rate. Here, we report that the splice variant of NRP/B contributes to tumorigenic activity in highly malignant gastric cancer through dissociation from the tumor repressor, HDAC5. NRP/B mRNA expression is significantly higher in the human g...