Cloning and characterization of the 5′-flanking region of the canine growth hormone gene

• Published in: Molecular and cellular endocrinology Vol. 197; no. 1; pp. 133 - 141
• Main Authors: Lantinga-van Leeuwen, Irma S, Timmermans-Sprang, Elpetra A.P, Mol, Jan A
• Format: Journal Article
• Language: English
• Published: Ireland Elsevier Ireland Ltd 29.11.2002
• Subjects: 5' Flanking Region; Amino Acid Sequence; Animals; Base Sequence; Binding Sites; Cloning, Molecular; Dog; Dogs - genetics; Growth Hormone - chemistry; Growth Hormone - genetics; Growth hormone promoter; Humans; Molecular Sequence Data; Progestins; Promoter Regions, Genetic; Protein Binding; Transcription Factors - metabolism; Dog; Growth hormone promoter; Progestins

The growth hormone (GH) gene is expressed in a variety of tissues outside the pituitary, including the mammary gland. GH expression in the mammary gland is stimulated by progestins. The local synthesis of mammary GH may provide a highly proliferative environment within the mammary gland that may con...