Proteomic Approaches to Unravel Mechanisms of Antibiotic Resistance and Immune Evasion of Bacterial Pathogens

The profound effects of and distress caused by the global COVID-19 pandemic highlighted what has been known in the health sciences a long time ago: that bacteria, fungi, viruses, and parasites continue to present a major threat to human health. Infectious diseases remain the leading cause of death w...

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Published inFrontiers in medicine Vol. 9; p. 850374
Main Authors Torres-Sangiao, Eva, Giddey, Alexander Dyason, Leal Rodriguez, Cristina, Tang, Zhiheng, Liu, Xiaoyun, Soares, Nelson C.
Format Journal Article
LanguageEnglish
Published Switzerland Frontiers Media S.A 02.05.2022
Subjects
antibiotic resistance
host-pathogen interactions
mass spectometry
Medicine
PTMs (post-translational modifications)
SWATH-MS
system biology
SWATH-MS
host-pathogen interactions
system biology
antibiotic resistance
mass spectometry
PTMs (post-translational modifications)
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Abstract The profound effects of and distress caused by the global COVID-19 pandemic highlighted what has been known in the health sciences a long time ago: that bacteria, fungi, viruses, and parasites continue to present a major threat to human health. Infectious diseases remain the leading cause of death worldwide, with antibiotic resistance increasing exponentially due to a lack of new treatments. In addition to this, many pathogens share the common trait of having the ability to modulate, and escape from, the host immune response. The challenge in medical microbiology is to develop and apply new experimental approaches that allow for the identification of both the microbe and its drug susceptibility profile in a time-sensitive manner, as well as to elucidate their molecular mechanisms of survival and immunomodulation. Over the last three decades, proteomics has contributed to a better understanding of the underlying molecular mechanisms responsible for microbial drug resistance and pathogenicity. Proteomics has gained new momentum as a result of recent advances in mass spectrometry. Indeed, mass spectrometry-based biomedical research has been made possible thanks to technological advances in instrumentation capability and the continuous improvement of sample processing and workflows. For example, high-throughput applications such as SWATH or Trapped ion mobility enable the identification of thousands of proteins in a matter of minutes. This type of rapid, in-depth analysis, combined with other advanced, supportive applications such as data processing and artificial intelligence, presents a unique opportunity to translate knowledge-based findings into measurable impacts like new antimicrobial biomarkers and drug targets. In relation to the Research Topic “Proteomic Approaches to Unravel Mechanisms of Resistance and Immune Evasion of Bacterial Pathogens,” this review specifically seeks to highlight the synergies between the powerful fields of modern proteomics and microbiology, as well as bridging translational opportunities from biomedical research to clinical practice.
AbstractList The profound effects of and distress caused by the global COVID-19 pandemic highlighted what has been known in the health sciences a long time ago: that bacteria, fungi, viruses, and parasites continue to present a major threat to human health. Infectious diseases remain the leading cause of death worldwide, with antibiotic resistance increasing exponentially due to a lack of new treatments. In addition to this, many pathogens share the common trait of having the ability to modulate, and escape from, the host immune response. The challenge in medical microbiology is to develop and apply new experimental approaches that allow for the identification of both the microbe and its drug susceptibility profile in a time-sensitive manner, as well as to elucidate their molecular mechanisms of survival and immunomodulation. Over the last three decades, proteomics has contributed to a better understanding of the underlying molecular mechanisms responsible for microbial drug resistance and pathogenicity. Proteomics has gained new momentum as a result of recent advances in mass spectrometry. Indeed, mass spectrometry-based biomedical research has been made possible thanks to technological advances in instrumentation capability and the continuous improvement of sample processing and workflows. For example, high-throughput applications such as SWATH or Trapped ion mobility enable the identification of thousands of proteins in a matter of minutes. This type of rapid, in-depth analysis, combined with other advanced, supportive applications such as data processing and artificial intelligence, presents a unique opportunity to translate knowledge-based findings into measurable impacts like new antimicrobial biomarkers and drug targets. In relation to the Research Topic "Proteomic Approaches to Unravel Mechanisms of Resistance and Immune Evasion of Bacterial Pathogens," this review specifically seeks to highlight the synergies between the powerful fields of modern proteomics and microbiology, as well as bridging translational opportunities from biomedical research to clinical practice.
The profound effects of and distress caused by the global COVID-19 pandemic highlighted what has been known in the health sciences a long time ago: that bacteria, fungi, viruses, and parasites continue to present a major threat to human health. Infectious diseases remain the leading cause of death worldwide, with antibiotic resistance increasing exponentially due to a lack of new treatments. In addition to this, many pathogens share the common trait of having the ability to modulate, and escape from, the host immune response. The challenge in medical microbiology is to develop and apply new experimental approaches that allow for the identification of both the microbe and its drug susceptibility profile in a time-sensitive manner, as well as to elucidate their molecular mechanisms of survival and immunomodulation. Over the last three decades, proteomics has contributed to a better understanding of the underlying molecular mechanisms responsible for microbial drug resistance and pathogenicity. Proteomics has gained new momentum as a result of recent advances in mass spectrometry. Indeed, mass spectrometry-based biomedical research has been made possible thanks to technological advances in instrumentation capability and the continuous improvement of sample processing and workflows. For example, high-throughput applications such as SWATH or Trapped ion mobility enable the identification of thousands of proteins in a matter of minutes. This type of rapid, in-depth analysis, combined with other advanced, supportive applications such as data processing and artificial intelligence, presents a unique opportunity to translate knowledge-based findings into measurable impacts like new antimicrobial biomarkers and drug targets. In relation to the Research Topic "Proteomic Approaches to Unravel Mechanisms of Resistance and Immune Evasion of Bacterial Pathogens," this review specifically seeks to highlight the synergies between the powerful fields of modern proteomics and microbiology, as well as bridging translational opportunities from biomedical research to clinical practice.The profound effects of and distress caused by the global COVID-19 pandemic highlighted what has been known in the health sciences a long time ago: that bacteria, fungi, viruses, and parasites continue to present a major threat to human health. Infectious diseases remain the leading cause of death worldwide, with antibiotic resistance increasing exponentially due to a lack of new treatments. In addition to this, many pathogens share the common trait of having the ability to modulate, and escape from, the host immune response. The challenge in medical microbiology is to develop and apply new experimental approaches that allow for the identification of both the microbe and its drug susceptibility profile in a time-sensitive manner, as well as to elucidate their molecular mechanisms of survival and immunomodulation. Over the last three decades, proteomics has contributed to a better understanding of the underlying molecular mechanisms responsible for microbial drug resistance and pathogenicity. Proteomics has gained new momentum as a result of recent advances in mass spectrometry. Indeed, mass spectrometry-based biomedical research has been made possible thanks to technological advances in instrumentation capability and the continuous improvement of sample processing and workflows. For example, high-throughput applications such as SWATH or Trapped ion mobility enable the identification of thousands of proteins in a matter of minutes. This type of rapid, in-depth analysis, combined with other advanced, supportive applications such as data processing and artificial intelligence, presents a unique opportunity to translate knowledge-based findings into measurable impacts like new antimicrobial biomarkers and drug targets. In relation to the Research Topic "Proteomic Approaches to Unravel Mechanisms of Resistance and Immune Evasion of Bacterial Pathogens," this review specifically seeks to highlight the synergies between the powerful fields of modern proteomics and microbiology, as well as bridging translational opportunities from biomedical research to clinical practice.
Author Giddey, Alexander Dyason
Torres-Sangiao, Eva
Soares, Nelson C.
Leal Rodriguez, Cristina
Tang, Zhiheng
Liu, Xiaoyun
AuthorAffiliation 5 Division of Chemical and Systems Biology, Department of Integrative Biomedical Sciences, Faculty of Health Sciences, University of Cape Town , Cape Town , South Africa
2 Instituto de Investigación Sanitaria Marqués de Valdecilla (IDIVAL) , Santander , Spain
3 Sharjah Institute of Medical Research, University of Sharjah , Sharjah , United Arab Emirates
4 Department of Medicinal Chemistry, College of Pharmacy, University of Sharjah , Sharjah , United Arab Emirates
7 Department of Microbiology, School of Basic Medical Sciences, Peking University Health Science Center , Beijing , China
6 Copenhagen Prospectives Studies on Asthma in Childhood, COPSAC, Copenhagen University Hospital , Herlev-Gentofte , Denmark
1 Clinical Microbiology Lab, University Hospital Marqués de Valdecilla , Santander , Spain
AuthorAffiliation_xml – name: 2 Instituto de Investigación Sanitaria Marqués de Valdecilla (IDIVAL) , Santander , Spain
– name: 5 Division of Chemical and Systems Biology, Department of Integrative Biomedical Sciences, Faculty of Health Sciences, University of Cape Town , Cape Town , South Africa
– name: 4 Department of Medicinal Chemistry, College of Pharmacy, University of Sharjah , Sharjah , United Arab Emirates
– name: 7 Department of Microbiology, School of Basic Medical Sciences, Peking University Health Science Center , Beijing , China
– name: 1 Clinical Microbiology Lab, University Hospital Marqués de Valdecilla , Santander , Spain
– name: 3 Sharjah Institute of Medical Research, University of Sharjah , Sharjah , United Arab Emirates
– name: 6 Copenhagen Prospectives Studies on Asthma in Childhood, COPSAC, Copenhagen University Hospital , Herlev-Gentofte , Denmark
Author_xml – sequence: 1
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  surname: Torres-Sangiao
  fullname: Torres-Sangiao, Eva
– sequence: 2
  givenname: Alexander Dyason
  surname: Giddey
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  givenname: Xiaoyun
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– sequence: 6
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BackLink https://www.ncbi.nlm.nih.gov/pubmed/35586072$$D View this record in MEDLINE/PubMed
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Copyright Copyright © 2022 Torres-Sangiao, Giddey, Leal Rodriguez, Tang, Liu and Soares.
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Keywords SWATH-MS
host-pathogen interactions
system biology
antibiotic resistance
mass spectometry
PTMs (post-translational modifications)
Language English
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Edited by: Mattias Collin, Lund University, Sweden
Reviewed by: Christofer Karlsson, Lund University, Sweden; Jennifer Geddes-McAlister, University of Guelph, Canada
These authors have contributed equally to this work
This article was submitted to Infectious Diseases – Surveillance, Prevention and Treatment, a section of the journal Frontiers in Medicine
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Snippet The profound effects of and distress caused by the global COVID-19 pandemic highlighted what has been known in the health sciences a long time ago: that...
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SubjectTerms antibiotic resistance
host-pathogen interactions
mass spectometry
Medicine
PTMs (post-translational modifications)
SWATH-MS
system biology
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Title Proteomic Approaches to Unravel Mechanisms of Antibiotic Resistance and Immune Evasion of Bacterial Pathogens
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